Chomera cha chikasu chomwe chimadulidwa ndi mtengo wa mukul myrrh ( Commiphora mukul ), guggul wakhala akugwiritsidwa ntchito kwa zaka zikwi zikwi mu ayurveda (mankhwala achipatala a India). Mankhwala a ayurvedic kawirikawiri amaphatikizapo kachidutswa ka guggul ndi zinthu zina zachibadwa kuti azichiritsa matenda monga matenda a nyamakazi, zotupa m'mimba, ndi matenda a mkodzo. Guggul imaperekedwanso ngati mankhwala ochotsera acne, komanso kupweteka kwa thupi.
Ubwino Wathanzi wa Guggul
Pakali pano, chithandizo cha sayansi cha phindu la guggul chikusowa.
1) Cholesterol Chokwera
Ngakhale kuti guggul imagwiritsidwa ntchito kwambiri ku India kulimbana ndi cholesterol chokwanira, kafufuzidwe ka chotsitsa chotsitsa cha mafuta m'thupi chimatulutsa zotsatira zosiyana. Kafukufuku wa chaka cha 2009 wa anthu 43 akulu omwe ali ndi cholesterol chokwanira kwambiri, adapeza kuti omwe anatenga 2,160 mg ya guggul mu mawonekedwe a capsule tsiku ndi tsiku anali ndi kuchepa kwakukulu kwa mafuta m'thupi kuposa omwe adatenga pilisi ya placebo. Komabe, mamembala omwe adagwiritsa ntchito guggul sanasonyeze kuchepa kwakukulu m'magulu awo a LDL ("bad") cholesterol.
Kafukufuku wina, wofalitsidwa mu 2003, anapatsa akuluakulu 103 omwe ali ndi cholesterol chokwanira kutenga 1000 mg kapena 2,000 mg ya guggul tsiku masabata asanu ndi atatu ndipo adapeza kuti chotsitsa cha LDL cholesterol.
Zambiri: mankhwala achilengedwe kuti achepetse cholesterol .
2) Kutupa
Kafukufuku woyambirira amasonyeza kuti chotupa cha guggul chingathandize kulimbana ndi zotupa.
Kafukufuku wina wa 2007 pa maselo a umunthu adapeza kuti guggulsterone (kampani yomwe imapezeka mu guggul) inachititsa imfa ya maselo a khansa ya prostate, pamene lipoti la 2008 linanena kuti guggulsterone inalepheretsa kukula kwa zotupa za khungu m'magulu.
3) Osteoarthritis
Kafukufuku wina amasonyeza kuti chotupa cha guggul chingathandize kuchepetsa zizindikiro za osteoarthritis wa bondo.
Phunzirani za mankhwala achilengedwe a osteoarthritis .
Mipango
Dothi la Guggul lingayambitse mavuto monga mutu, kunyozetsa, ndi kukwiya kwa khungu (kawirikawiri ngati kutentha) mwa anthu ena. Popeza guggul yapezedwanso kuti ayambe kutulutsa chithokomiro, aliyense amene ali ndi vuto la chithokomiro ayenera kuonana ndi dokotala asanayambe kugwiritsa ntchito gudgul.
Mufukufuku wa 2004, asayansi adapeza kuti guggulsterone ingalepheretse kugwiritsa ntchito mankhwala osokoneza bongo omwe amatsitsimutsidwa ndi michere ya CYP3A ya thupi. Mankhwalawa akuphatikizapo Lipitor, cyclosporine, ndi quinidine.
Zakudya sizinayesedwe kuti zikhale zotetezeka komanso chifukwa chakuti zakudya zowonjezera zakudya zimakhala zosavomerezeka, zomwe zilipo zingakhale zosiyana ndi zomwe zafotokozedwa palemba. Komanso kumbukirani kuti chitetezo cha mankhwala opatsirana mwa amayi apakati, amayi oyamwitsa, ana, ndi omwe ali ndi matenda kapena omwe akumwa mankhwala sanakhazikitsidwe. Mukhoza kupeza njira zogwiritsira ntchito zowonjezereka apa , koma ngati mukuganizira kugwiritsira ntchito guggul, lankhulani ndi mtsogoleri wanu woyamba. Kudzisamalira komanso kupewa kapena kuchepetsa kusamalidwa kosatha kungakhale ndi zotsatira zoopsa.
> Zotsatira:
> Brobst DE, Ding X, Creech KL, Goodwin B, Kelley B, Staudinger JL. "Guggulsterone Imayambitsa Mitundu Yambiri ya Nyukiliya ndi Zopangira Cyp3a Gene Expression Kupyolera mu Pregnane X Receptor." Journal of Pharmacology and Experimental Therapeutics 2004 310 (2): 528-35.
> Nohr LA, Rasmussen LB, Straand J. "Resin Kuchokera ku Mukul Myrrh Tree, Guggul, Kodi Ikhoza Kugwiritsidwa Ntchito Pochiza Hypercholesterolemia?" Phunziro Lowonjezereka, Limene Limayang'aniridwa. "Njira Zothandizira Zothandizira Mankhwala 2009 Jan; 17 (1): 16-22 .
> Sarfaraz S, Siddiqui IA, Syed DN, Afaq F, Mukhtar H. "Guggulsterone Modulates MAPK ndi NF-kappaB Njira ndipo Zimaletsa Khungu la Matenda Achimuna M'madera a SENCAR." Carcinogenesis 2008 29 (10): 2011-8.
> Singh BB, Mishra LC, Vinjamury SP, Aquilina N, Singh VJ, Shepard N. "Mphamvu ya Commiphora Mukul ya Osteoarthritis ya Knee >> a > Zotsatira za Maphunziro." Njira Zochiritsira Zochiritsira M'maganizo ndi Zamankhwala 2003 9 (3): 74-9.
> Singh SV, Choi S, Zeng Y, Hahm ER, Xiao D. "Guggulsterone-Indoped Apoptosis mu Mankhwala a Khansa ya Mankhwala Opatsirana Amayamba Chifukwa cha Oxygen Okhazikika Pakati pa Ntchito Yoyamba ya c-Jun NH2-Terminal Kinase." Kafukufuku wa khansa 2007 1; 67 (15): 7439-49.
> Szapary PO, Wolfe ML, Bloedon LT, Cucchiara AJ, DerMarderosian AH, Cirigliano MD, Rader DJ. "Guggulipid kwa Chithandizo cha Hypercholesterolemia: Kuyesedwa kosalamulirika." JAMA 13; 290 (6): 765-72.