Kodi ndi njira yabwino komanso yothandiza?
Symmetrel (amantadine hydrochloride) ndi mankhwala oletsa tizilombo toyambitsa matenda omwe amagwiritsidwa ntchito pochiza matenda a Parkinson koma nthawi zambiri amalembedwa kuti asatope mwa anthu omwe ali ndi multiple sclerosis (MS) . Ankagwiritsidwanso ntchito pochiza matenda a chimfine koma adachotsedwa chifukwa cha kukanizidwa kwa amantadine.
Zotsatira zotsutsana ndi kutopa zinayamba kupezeka pamene anthu omwe ali ndi MS anachiritsidwa ku chifuwa cha Asia ndipo adapeza kuti mphamvu zawo zowonjezera zinali zodzidzimutsa ndipo zinawoneka bwino.
Ngakhale kuti Symmetrel lero ikufunsidwa kuti athetse kufooka kwa MS , sikunayambe kuvomerezedwa kuti ntchitoyi ndi US Food and Drug Administration.
Momwe Zimagwirira Ntchito
Symmetrel imagwira ntchito yapakati pa mitsempha yambiri komanso imathandizira kupanga dopamine, mankhwala osokoneza bongo omwe amafanana ndi adrenaline. Dopamine imakhudza mbali ya ubongo wodziwika kuti basal ganglia yomwe imathandiza kuti kayendetsedwe ka kayendedwe kake, kaganizidwe ka mtima, komanso kukondwera ndikumva kupweteka.
Ngakhale kuti Symmetrel ikuwoneka kuti ikupereka phindu lenileni kwa anthu okhala ndi matenda a Parkinson, zofooka zimenezo zamasulirako mpumulo wofewa kwambiri kwa anthu omwe ali ndi kutopa kwa MS. Mchitidwe wachitidwe sichimvetsetsedwe kwathunthu, koma zowoneka kuti phindu ndiloti Symmetrel amalingaliridwa ndi ambiri kuti ndilo kusankha mzere woyamba kuti athetse vutoli lokhumudwitsa komanso lomwe nthawi zambiri limafooketsa.
Mphamvu ya Symmetrel
Kafukufuku wina amene anachitidwa mu 2014 anawonetsa kuti mankhwalawa ndi othandiza kwambiri chifukwa cha kusintha kwa Fatigue Impact Scale (MFIS) yomwe imayesa kutopa pamtunda wa 0 mpaka 84. Pambuyo pa mwezi umodzi, Symmetrel imagwiridwa ndi kuchepa kwa 34 peresenti chifukwa cha kutopa kwakutopa mwa anthu omwe ali ndi MS.
Ngakhale kuti ndi yofunikira, poyerekeza ndi mankhwala ena monga aspirin kapena acetyl-L-carnitine (chakudya chodziwika bwino chowonjezera), Symmetrel sichinawonetsedwe kukhala yothandiza.
Malangizo a Mlingo
Poyang'anira kutopa kumagwirizanitsa ndi MS, mlingo wokhazikika ndi 100 mpaka 200 mg tsiku lililonse, kutengedwa m'mawa kwambiri kuti usasokoneze tulo. Zimabwera mu maulamuliro onse awiri a lalanje komanso ngati mavitamini okoma.
Zotsatira Zochiza Chithandizo
Zotsatira zake za Symmetrel zimayesedwa ngati zazing'ono. Zizindikiro zowonjezereka zokhudzana ndi jitteriness ndi youma pakamwa. Mlingo wokhala pamwamba pa mamiligalamu 300 nthawi zina ukhoza kukhala moyo wa livingo reticularis, chikopa chokhala ndi nsalu zofiirira pamilingo.
Zotsatira zina za Symmetrel, nthawi zambiri, zimaphatikizapo:
- Kugonjera, makamaka ngati kutengedwa pambuyo pake
- Masomphenya obisika, makamaka anthu omwe ali ndi MS- optic neuritis
- Kutsekedwa
- Chizungulire
- Mzinda wosakanikirana
Zambiri mwa zizindikiro izi, monga kusowa tulo ndi kutaya kwa chikhodzodzo , zimagwirizanitsidwa ndi multiple sclerosis. Choncho, ndizofunika kuyang'anitsitsa kuwonjezereka kapena kuwonjezereka kwa zizindikiro zomwe mankhwala amayamba kamodzi kuti ayambe kuwunika bwino ngati chifukwa chake ndi mankhwala ozunguza bongo kapena kuti akhoza kubwereranso .
Zomwe zimagwiritsidwa ntchito komanso kutsutsana
Symmetrel iyenera kugwiritsidwa ntchito mosamala kwa anthu omwe ali ndi matenda a chiwopsezo, vuto la mtima, kusokonezeka kwa impso, kapena matenda ovutika maganizo pamene ntchito yake ingapangitse vuto lalikulu kapena kuyambitsa choipa.
Anthu omwe amapezeka ndi schizophrenia kapena matenda ena a psychotic sayenera kulamulidwa ngati Symmetrel ingawononge kwambiri matenda a maganizo.
Chifukwa cha kusowa kwa kafukufuku, Symmetrel sichivomerezedwa pa nthawi yomwe ali ndi mimba ngati sakudziwika ngati mankhwalawa amatha kuvulaza mwanayo. Tiyeneranso kupeĊµa nthawi yoyamwitsa ndi amayi omwe akukonzekera kutenga pakati.
> Zotsatira:
> Generali, J. ndi Cada, D. "Amantadine: Kutopa Kwambiri Kukhudzana ndi Matenda a Edzi." Hosp Pharm . 2014; 49 (8): 710-712.
> Utsogoleri wa US Food and Drug Administration. " Symmetrel (Amantadine Hydrochloride) Sirasi ndi Mapiritsi." Silver Springs, Maryland; zasinthidwa mwezi wa 2009.