Kusokoneza Malingaliro Amodzi Okhudza Zochitika Zokhudza Mankhwala a Sulfa
Sulfa zozizira ndi mawu omwe amagwiritsidwa ntchito kufotokoza mankhwala osokoneza bongo kwa sulfonamides, gulu la mankhwala omwe amaphatikizapo ma antibayotiki ndi mankhwala osagwiritsira ntchito mankhwala.
Pali maganizo omwe anthu ambiri amaganiza kuti mankhwala onse a sulfonamide angathe kuyambitsa matenda, koma izi siziri zoona. Mankhwala a antibiotic sulfonamides (omwe amagwiritsidwa ntchito pochiza matenda a bakiteriya) amachititsa kuti anthu asamangokhalira kudwala matenda osagwira ntchito.
Ngakhale kuti mankhwala onse ali ndi vuto loyambitsa matenda, mankhwala osagwiritsira ntchito mankhwala a sulfonamides ndizochepa.
Mwachidule
Nthawi zambiri, munthu yemwe ali ndi matenda okhudzana ndi sulfa adzalandira mankhwala osokoneza bongo amodzi kapena angapo:
- Septra (sulfamethoxazole ndi trimethoprim)
- Bactrim (sulfamethoxazole ndi trimethoprim)
- Pediazole (erythromycin ndi sulfafurazole)
Kuchita izi sizomwe si zachilendo ndipo kumakhudza pafupi anthu atatu peresenti ya anthu onse. Izi ndi mlingo wofanana ndi zomwe zikuwoneka ndi mitundu ina ya maantibayotiki, kuphatikizapo penicillin .
Anthu ena amawoneka kuti ali pachiopsezo chachikulu cha sulfa zovuta kuposa ena. Izi zimaphatikizapo anthu omwe, chifukwa cha zifukwa zosiyanasiyana, amatsitsa mankhwala pang'ono pang'onopang'ono kapena amatetezedwa ndi chitetezo cha m'thupi (omwe amalandira thupi ndi anthu omwe ali ndi HIV).
Zizindikiro
Zizindikiro ndi kuuma kwa sulfa zovuta zimasiyana koma kawirikawiri zimakhudza maonekedwe a chiphuphu chofala.
Njuchi ndi kuwala ( photosensitivity ) ndizofala.
Pa milandu yowopsya, kutuluka kwa mphutsi kungaperekedwe ndi kutupa kwa nkhope, manja, mapazi, ndi lirime (wotchedwa angioedema ). Izi nthawi zambiri zimakhala zoopsa zowopsya, zochitika zonse za thupi zomwe zimadziwika ngati matenda a Stevens-Johnson ndi matenda oopsa a epidermal necrolysis .
Zonsezi zimadziwika ndi kupweteka kwa khungu komanso imfa yambiri.
Kuwonetseranso kwina kwakukulu kwa mankhwala a sulfa ndi:
- Kuvulala kwa chiwindi, chodziwika ndi kukula kwa chiwindi cha chiwindi
- Kuwonongeka kwa impso kapena kulephera
- Chibayo-ngati matenda opuma
- Vasculitis , kupopera kwa mitsempha ya magazi ndi magazi
Ndikofunika kuthamanga mofulumira kwambiri ndi mankhwala osokoneza bongo ngakhale titakhala ofatsa bwanji. Nthawi zina, kugwiritsa ntchito mankhwala osokoneza bongo nthawi zonse kungasinthe kupweteka pang'ono kupita ku zoopsa zowopsa.
Kudziwa
Palibe magazi kapena khungu la khungu lomwe lingapezeke kuti lipeze matenda a sulfa. Matendawa amapangidwa kwathunthu poonetsa zizindikiro zomwe zimagwiritsidwa ntchito ndi mankhwala a sulfonamide.
Chithandizo
Kawirikawiri kulankhula, mzere woyamba wa chithandizo cha sulfa ndi kuchotsedwa kwa mankhwala akudandaula.
Chithandizo chamwadzidzidzi chingafunike kwa anthu omwe ali ndi zizindikiro za matenda a Stevens-Johnson kapena poizoni wa epidermal necrolysis. Izi makamaka zimaphatikizapo kuchipatala, madzi osakaniza, komanso njira zomwe zimagwiritsidwa ntchito pochita kutentha kwakukulu.
Mu milandu yowopsa kwambiri pamene mankhwala ozunguza sulfa amaonedwa kuti ndi ofunikira kuchiza matenda, tizilombo ting'onoting'ono tingaperekedwe ndipo pang'onopang'ono kuwonjezeka pamene mankhwalawa amalekerera bwino.
Izi kawirikawiri zimafuna kuyang'aniridwa ndi munthu wotsutsana ndi zochitika zoopsa.
Mankhwala Oyenera Kupewa
Anthu omwe amadziwika ndi sulfa zolimbitsa thupi ayenera nthawi zonse kukaonana ndi dokotala wawo kuti ayambe kumwa mankhwala atsopano. Izi ndi zowona makamaka kwa iwo amene adayankhapo kale.
Kuphatikiza pa maantibayotiki amlomo, mapuloteni a sulfonamides ayenera kupewedwa kuphatikizapo:
- Sulfacetamide madontho a diso, shampoo, kapena zokometsera
- Silver sulfadiazine mafuta opangira mankhwala
- Kukonzekera kwa amayi a Sulfanilamide
Mofananamo, mankhwala osokoneza bongo Azulfidine (sulfasalazine) , omwe amagwiritsidwa ntchito pochizira matenda opatsirana ndi nyamakazi, ayenera kupeŵa.
Komano, chiopsezo choyambiranso ku antibiotic sulfonamides ndi chochepa. Izi zikutanthauza kuti nthawi zambiri zimakhala zotetezeka kutenga mankhwala awa:
- Diuretics (mapiritsi a madzi) monga HCTZ (hydrochlorothiazide) ndi Lasix (furosemide)
- Oral sulfonylureas-mankhwala osokoneza bongo omwe amagwiritsidwa ntchito pochiza matenda a shuga
- Celebrex (celecoxib), COX-2 inhibitor yogwiritsidwa ntchito pochizira nyamakazi ndi ululu
Sulfite ndi Sulphate Allergies
Anthu nthawi zambiri amalakwitsa mankhwala a sulfa chifukwa cha matenda a sulfite , omwe amatha kukhala okhudzana ndi zakudya zomwe zimapezeka mu zakudya ndi mankhwala. Izi zikuphatikizapo othandizira otetezera monga:
- Sulfite ya sodium
- Bisulfite ya sodium
- Metabisulfite sodiamu
- Potaziyamu bisulfite
- Potaziyamu metabisulfite
Ngakhale kuti sulfites ikhoza kuyambitsa matenda , palibe kugwirizana pakati pa sulfa ndi sulfite matenda. Momwemo, munthu yemwe ali ndi masewera a sulfa sayenera kupeŵa sulfites (kapena mosiyana).
Chimodzimodzinso ndi mankhwala omwe ali ndi sulfuric acid wotchedwa sulfates . Mofanana ndi sulfites, sulphate ikhoza kuyambitsa matenda, koma mankhwalawa sali okhudzana ndi sulfonamides kapena sulfa-matenda oopsa. Izi zikuphatikizapo mankhwala monga:
- Albuterol sulphate yogwiritsira ntchito mankhwala opweteka
- Iron sulphate yomwe imagwiritsidwa ntchito popanga kuchepa kwa magazi m'thupi
- Chondroitin sulphate yomwe imagwiritsidwa ntchito pochizira osteoarthritis
- Codeine sulphate, mankhwala opioid ogwiritsidwa ntchito popuma kupweteka
Mawu Ochokera
Maonekedwe a sulfa zovuta zitha kukhala zonyansa kutulutsa kunja, ngakhale kwa ena othandizira zaumoyo. Ichi ndi chifukwa chake nkofunika kuuza dokotala wanu za zomwe munayankha kale zomwe mwakhala mukuyenera kuti mukhale ndi mankhwala a sulfa (kapena mankhwala enaake).
Pochita zimenezi, dokotala wanu adzatha kupeza cholowa chochepa chothetsa vutoli.
> Zotsatira:
> Gulu logwira ntchito limodzi pa Parameters, ndi al. "Mankhwala osokoneza bongo: ndondomeko yowonongeka." Ann Zozizira Nthenda Immunol. 2010; 105 (4): 259-73. DOI: 10.1016 / j.anai.2010.08.002.
> Wulf, N. ndi Matuszewski, K. "Sulfonamide cross-reactivity: kodi pali umboni wosonyeza kuti paliponse paliponse?" Am J Health Pharm . 2013 Sep 1; 70 (17): 1483-94. DOI: 10.2146 / ajhp120291.
> Zawodniak, A .; Lochmatter, P .; Beeler, A. et al. "Kuchulukanso m'maganizo mwa mankhwala osokoneza bongo amachititsa sulfasalazine ndi sulfamethoxazole." Int Arch Zozizira Immunol. 2010; 153 (2): 152-6. DOI: 10.1159 / 000312632.