Kodi Kupweteka Kwambiri kwa Mankhwala Kumayambitsa IBS Yanu?
Kodi mankhwala anu opweteka mtima angapangitse zizindikiro zanu za IBS ? Ochita kafukufuku akuyang'ana momwe mungagwiritsire ntchito mgwirizano pakati pa kugwiritsa ntchito proton pump inhibitors (PPIs) ndi kupitirira kwabakiteriya kakang'ono ka m'matumbo (SIBO). Popeza SIBO ikuganiza kuti ndiyake chifukwa cha mabungwe ena a IBS , ubale uliwonse pakati pa atatuwu uyenera kuyang'ana.
Kodi ma PPI ndi ati?
Mankhwalawa ndi mankhwala omwe amathandiza kuthetsa kusamalidwa kwa m'mimba mwa asidi.
Amalangizidwa kuti azitha kuchiza matenda osiyanasiyana, kuphatikizapo matenda a reflux a gastroesophageal (GERD) ndi zilonda zam'mimba. Ngakhale ma PPI ambiri amafunika mankhwala, pali ena omwe ali oposa. Zotsatirazi ndi zitsanzo za ma PPI:
- Aciphex
- Wokondedwa
- Kapidex
- Nexium
- Prevacid
- Prilosec
- Protonix
- Zegerid
Ngakhale kuti ma PPI amadziwika kuti ndi otetezeka, amatha kukhala ndi chiwopsezo chochepa cha chibayo, komanso kuopsa kwa matenda a C difficile .
Kodi SIBO ndi chiyani?
SIBO ndi chikhalidwe chomwe chimakhala ndi mavitamini ambiri m'matumbo aang'ono . Mabakiteriyawa amachititsa zakudya zomwe mumadya, zomwe zimawathandiza kuti azitentha komanso kutupa m'mimba. Zizindikiro za SIBO zikuphatikizapo:
- Kupweteka m'mimba
- Kutseka
- Kutsekula m'mimba
- Kusiyanitsa
- Flatulence
Kulumikizana pakati pa IBS ndi SIBO kumakhala kovuta kwambiri. Izi ziyenera kuchitika, kuti zikhale zovuta ndi kudziwa bwino SIBO.
Chidziwitso chotsimikizirika chikhoza kupangidwa pochita chikhalidwe chachindunji, komabe, pakuchita, odwala amapezeka kuti akuyesa kugwiritsa ntchito mayeso a mpweya wa haidrojeni , kuyesedwa kochepa, koma kosadalirika. Ngakhale kuti ziwerengero zina zimakhala zovuta kwambiri pakati pa IBS ndi SIBO, zikutheka kuti SIBO imakhala ndi gawo limodzi mwa odwala a IBS.
Vuto lina ndilo kuti si onse omwe amavomereza SIBO kuti ndi matenda. Anthu ambiri akhoza kukhala ndi umboni wa SIBO popanda zizindikiro. Choncho SIBO sichimveka bwino ndipo zambiri zomwe zikhoza kunenedwa kuti ndizomwe zimagwiritsidwa ntchito nthawi zina kuti zizindikire zizindikiro za munthu.
Kafukufuku Wowonjezera Wowonjezeka Pakati pa PPI Ntchito ndi SIBO
Chiphunzitso chakuti PPI ntchito zimathandizira kuti chitukuko cha SIBO chizikwaniritsidwe chifukwa chakuti mimba ya asidi ndi imodzi mwa zinthu zomwe zimathandiza kupewa mabakiteriya ambiri m'mimba. Choncho, kuchepa kwa mimba ya asidi chifukwa cha ntchito ya PPI, pamene ikugwira ntchito poyambitsa kupweteka kwa mtima ndi zilonda, kungayambitse mavuto m'munsi mwa chimbudzi .
Inde, kafukufuku wapeza kuti kuchepa kwa m'mimba ya asidi kungawonjezere kuchuluka kwa mabakiteriya m'matumbo aang'ono. Chimene sichiri chowonekera bwino, ndi chakuti kuwonjezeka kumeneku kumabweretsa chitukuko cha SIBO ndi zizindikiro zake.
Mu kafukufuku wina, pafupifupi theka la odwala omwe anatenga PPIs nthawi yaitali anayesedwa zabwino kwa SIBO. Zizindikiro zawo zinawonjezeka kwambiri pakapita nthawi, ndipo zizindikiro zimayambira mofatsa kwa miyezi isanu ndi umodzi yoyamba, koma zimakula mofulumira komanso mopitirira muyeso.
Kuwombera ndi kutsegula m'mimba ndizo zizindikiro zazikuluzikulu zodziwika, pomwe peresenti ya odwala inanena kuti kudzimva ndi kupweteka m'mimba.
Phunziro laling'ono, anthu omwe anali ndi GERD (non-GERD) omwe sali okonzeka (NERD) komanso omwe sananene kuti ali ndi zizindikiro zina zapathupi anapatsidwa PPI kwa miyezi isanu ndi umodzi. Patapita masabata asanu ndi atatu achiritsidwe, pafupifupi theka la odwala adadandaula chifukwa chogwedezeka, pamene nambala zing'onozing'onoting'ono zidandaula za kukhumudwa, kupweteka m'mimba, ndi kutsekula m'mimba. Pambuyo pa miyezi isanu ndi umodzi ya kuchiritsidwa, pafupifupi mmodzi mwa anayi a odwala anayesera kuti SIBO apitirize kuyesedwa, ndipo pafupifupi theka la odwala ali ndi zoyenera kuti azindikire .
Kusanthula meta pa phunziro lomwe linapezeka kuti panali umboni wa mgwirizano wa PPI / SIBO m'maphunziro omwe amagwiritsa ntchito zikhalidwe za minofu kuti apeze SIBO, koma osati mwa omwe amagwiritsa ntchito mpweya. Mwachiwonekere, kufufuza kwina kumafunika, ndipo zina zowonjezereka mwa momwe SIBO amapezera.
Mfundo Yofunika Kwambiri
Mpaka SIBO itamvetsetsedwa bwino, kapena mayesero ozindikiritsa owonjezereka amayamba, sizingatheke kuti pulogalamu iliyonse ya PPI / SIBO / IBS ilipo. Ngati muli ndi nkhawa yokhudzana ndi mgwirizano pakati pa PPI ndi IBS, kambiranani nkhaniyi ndi dokotala wanu.
Zotsatira:
Yerekezani, D., et.al. "Zotsatira za mankhwala a PPI kwa nthawi yaitali popanga zizindikiro za m'mimba ndi SIBO." European Journal of Clinical Investigation 2011 41: 380-386.
Johnson, D. & Oldfield, E. "Zotsatira Zowonongeka ndi Zovuta za Pulogalamu Yambiri ya Pulotoni Pulojekiti Ntchito: Kusokoneza Umboni" Clinical Gastroenterology ndi Hepatology 2013 11: 458-464.
Onani, W. & Walter, W. "Proton Pump Inhibitor Kugwiritsa Ntchito ndi Kuopsa kwa Kukula Kwabakiteriya Kakang'ono M'mimba: Kufufuza Meta" Clinical Gastroenterology ndi Hepatology 2013 11: 483-490.
Lombardo, L., et.al. "Kuwonjezeka Kwambiri kwa Kuphatikizidwa Kwabakiteriya Kakang'ono M'kati mwa Proton Pump Inhibitor Therapy" Clinical Gastroenterology ndi Hepatology 2010 8: 504-508.
Minocha, A. & Adamec, C. (2011) The Encyclopedia of the Digestive System ndi Digestive Disorders (2nd Ed.) New York: Mfundo pa Fayilo.