Kodi P53 ndi Ntchito Yotani mu Kansa?
Kodi p53 Gene ndi chiyani?
Kodi ndondomeko ya p53 ndi yani makamaka yomwe ikuthandizira pa chitukuko ndi kukula kwa khansa?
P53 Gene ndi Gene Wosamalidwa ndi Matenda
Geni ya p53 ndi jini yomwe imayimira mapuloteni omwe amaletsa kukula ndi kukula kwa zotupa (kuphatikizapo ntchito zina). Amadziwika kuti chotupa choyambitsa jini . Ngati minofu imasinthidwa-ndiko kuti, kusinthidwa mwanjira inayake ndi chilengedwe kapena cholowa, maselo owonongeka amaloledwa kupulumuka, ndipo potsirizira pake, amakhala maselo a khansa.
P53 Gene Mutation ndi Common
Kusinthika kwa p53 gene (komwe kuli pa chromosome 17) ndimasintha kwambiri omwe amapezeka mu maselo a khansa ndipo amakhalapo pa 50% ya khansa.
Kodi p53 Gene Do ndi chiyani?
Geni ya p53 imayambitsa mapuloteni omwe angathe kukonzanso maselo owonongeka kapena chifukwa cha maselo owonongeka kufa, ndondomeko yotchedwa apoptosis. Pamene jini silikugwira ntchito chifukwa cha kusintha kwa thupi, mapuloteni ameneŵa omwe amakonza maselo kapena kuthetsa maselo osokonekera sali opangidwa, ndipo maselo osadziwika amaloledwa kugawanika ndi kukula.
Njira yosavuta kwambiri yowonera p53 gene ndiyo kudziwonetsera nokha ngati geni ya p53, ndi mapulogalamu monga mapuloteni omwe mungathe kuwongolera. Ngati muli ndi madzi otsika ndipo "mukugwira bwino ntchito," mutha kuyimbira fumbi. Chowombera chimatha kubwera kunyumba kwanu ndi kukonzanso mfuti yachinyontho kapena kuchichotsa kwathunthu kuti imitsetse madzi.
Ngati simunathe kupanga foni (yofanana ndi p53 gene), chowombera sichidzatchedwa ndipo kutsika kudzapitirira (kufanana ndi maselo a khansa yogawanitsa), ndipo potsirizira pake kusefukira kwanu.
Mwa kuyankhula kwina, p53 jini imagwira ntchito ngati chitetezo choteteza chitetezo chomwe chimalepheretsa maselo osadziwika kuti akhale otupa mu njira zitatu zoyambirira (monga panthawiyi - pali zambiri zomwe tikufunikira kuphunzira p53.) Ndi:
- Kukonza kuwonongeka mu DNA isanafike maselo owonongeka agawanika (ndi kulakwitsa.)
- Zimayambitsa apoptosis. Pamene kuwonongeka kwa DNA kuli kochuluka kuti kukonzedwe, majeremusi otha kupweteka kwambiri amachititsa kuti maselo aphatikizidwe afe (apoposisi) kotero kuti kuwonongeka sikudutsa.
- P53 mwinamwake ili ndi ntchito zina zambiri, kuphatikizapo zotsatira pa kagayidwe kake kamene kamathandiza kwambiri kukula kwa khansa.
Nchiyani Chimachititsa Kuwonongeka kwa Gene P53?
Jini la p53 likhoza kuonongeka (kusinthidwa) ndi zinthu zopangitsa khansa m'deralo , monga utsi wa fodya . Zingakhalenso kupezeka kwa anthu ena kuchokera kubadwa. Anthu omwe amadzalandira kope limodzi la p53 jini (Li-Fraumeni syndrome) amayamba kukhala ndi khansa patapita nthawi.
Kufunika kwa p53 Gene mu khansa ya m'mimba
Kumvetsetsa kwa jini la p53 ndi mapuloteni omwe amachititsa kuti izi zitheke kungathandize njira yabwino yodziwira ndi kuchiza khansa ya m'mapapo m'tsogolomu.
Zotsatira:
Demirani, O. et al. Zina mwa majeremusi a p16 ndi p53 ndi zotsatira za chromosomal kwa odwala khansa ya m'mapapo: Fluorescence in situ hybridization ndi maphunziro a cytogenetic. Kansa Epidemiology . 2010 May 3. (Epub patsogolo pa kusindikiza).
Farnebo, M. et al. P53 tumor supprossor: wolamulira wamkulu wa njira zosiyanasiyana zamagulu ndi chithandizo cha khansa. Sayansi ya Zachilengedwe ndi Zophatikiza Zofufuza Zachilengedwe . 2010. 396 (1): 85-9.
Hecht. S. Kupita patsogolo ndi mavuto m'madera osankhidwa a fodya ya carcinogenis. Kafukufuku wamakono mu Toxicology . 2008. 21 (1): 160-71.
Ofatsa, D. Malamulo a kuyankha kwa p53 ndi ubale wake ndi khansa. Magazini Yachilengedwe . 2015. 469 (3): 325-46.
Muller, P., ndi K. Youden. kusintha kwa p53 mu khansara. Nature Cell Biology . 2013. 15 (1): 2-8
Pfeifer, G. ndi A. Besaratinia. Maseŵera amatsenga a khansa yaumunthu. Human Genetics . 2009. 125 (5-6): 493-506.
Wang, X., Simpson, E., ndi K. Brown. p53: Chitetezo pa Kukula kwa Matenda osagonjetsa Pakati pa Mliri ndi Apoptosis. Kafukufuku wa Khansa . 2015 Nov 16. (Epub patsogolo pa kusindikiza).