Kodi Ma Statins Angakhudze Bwanji Anthu Amene Ali ndi Khansa Yam'mimba?
Statin Mankhwala ndi Khansa Yam'mimba
Mwinamwake mwamvapo kuti mankhwala a statin amatha kupulumutsa khansa ya m'mapapo, kuthandizira kuchipatala, kapenanso kuchepa kwa khansa ya m'mapapo. Pakati pa zonsezi, kodi maphunzirowa amasonyeza chiyani? Kodi akukamba za kupewa khansa ya m'mapapo isanayambike, kapena ikudwala khansara yamapapo mukatha kale? Kodi mtundu wa khansara wamapapu ndi wotani ndi mankhwala ena omwe mukuwagwiritsa ntchito?
Nthaŵi zina asayansi amadabwa pamene chithandizo cha chikhalidwe chimodzi chimawoneka kuti chikuthandizira kukhala wosagwirizana. Mankhwala otchedwa Statins angakhale amodzi mwa mankhwalawa. Mankhwalawa omwe amachepetsa cholesterol pakati pa ntchito zina ndi mankhwala ena omwe amadziwika kwambiri padziko lonse lapansi. Ochita kafukufuku apanga chidwi kwambiri ndi mankhwalawa m'zaka zaposachedwapa atatha kuona mgwirizano pakati pa kugwiritsa ntchito mankhwalawa ndi matenda a khansa.
Kodi Statins ndi chiyani?
Statins ndi gulu la mankhwala otchedwa HMG-CoA reductase inhibitors. Ngakhale anthu ambiri amaona kuti mankhwalawa ndi "mankhwala ochepetsa mafuta m'thupi". Cholinga chawo chachikulu ndi kuchepetsa chiopsezo cha mtima. Kuwonjezera pa kuchepetsa kolesterolini, mankhwalawa amaletsa ziwalo zamakono m'mitsempha ya m'mimba , kuchepetsa kukula kwa chipika mu mitsempha yamakono, ndi kuchepetsa kupangika kwa magazi mu mitsempha yamakono. Momwemonso, statins ikhoza kuchepetsa ngozi ya mtima ngakhale cholesterol wamba.
Ku mbali inayo ya equation, kuchiza cholesterol m'magulu okha - popanda kupatula kusiyana kwa thanzi ndi moyo - si cholinga cha mankhwala a statin.
Kodi Statins Angakhudze Bwanji Ngozi ya Khansa?
Maphunziro a zinyama ndi maphunziro a maselo (kuyang'ana pa maselo a khansa omwe ali kudya) adanena kuti statins ali ndi zotsutsana ndi khansa.
Iwo amaganiza kuti akhoza kuletsa kukula kwa maselo, kutuluka, ndi kuthekera kwa maselo a kansa kufalikira (kuchepetsa mphamvu).
Malingana ndi kagulu kena ka akatswiri, ma statins omwe ali ndi lipophilic (okonda mafuta) angakhale othandiza kwambiri. Mafilimu ena a lipophilic ndi Lipitor (atorvastatin), Zocor (simvastatin), ndi Mevacor (lovastatin). Zolemba zapopophilic (zowonjezera kwambiri za hydrophilic kapena "okonda madzi") zimaphatikizapo Pravachol (pravastatin), Crestor (rosuvastatin), ndi Lescol (fluvastatin).
Statins ndi Mapuloteni a Khansa
Kafukufuku waposachedwapa amasonyeza kuti anthu omwe amamwa mankhwala osokoneza bongo asanayambe kapena atapezeka kuti ali ndi kansa ya m'mapapo akhoza kukhala ndi kuchulukitsitsa kwa moyo.
Phunziroli la anthu pafupifupi 14,000 omwe ali ndi khansara yamapapu ku UK pakati pa 1998 ndi 2009, anthu omwe anali kugwiritsa ntchito mankhwala osokoneza bongo asanayambe kupeza mankhwala anali ndi chiwerengero chochepa cha kufala kwa khansa ya m'mapapo.
Kwa omwe amagwiritsira ntchito mankhwala osokoneza bongo pambuyo powapeza , ndipo amakhala ndi miyezi isanu ndi umodzi, panalibe kuchepa kwakukulu kwa kufala kwa khansa yamapapo ya 11 peresenti. Kwa iwo omwe adadzaza malamulo awo nthawi 12 (kugwiritsira ntchito chaka chimodzi kapena kuposerapo,) panali kuchepa kwakukulu kwa chiwerengero cha kufa kwa khansa yamapapo ya 19 peresenti.
Kafukufukuyu anali ndi anthu omwe ali ndi khansara ya m'mapapo yomwe siing'ono yaing'ono komanso khansa yaing'ono yamapapu ya m'mapapo ndipo amatanthawuza odwala khansa ya m'magazi 3,638 omwe anali ndi zochepa zowonjezera kufa kwa khansa yamapapo. Ngati nambalayi iyenera kugwiritsidwa ntchito kwa anthu ambiri omwe ali ndi khansara yamapapu, izi sizingakhale nambala yaing'ono, popeza kuti anthu 158.040 adzafa ndi khansa ya m'mapapo mu 2015 ku United States okha. Poyerekezera mwamsanga, pafupifupi 3,000 anthu amafa pamoto wamoto ku United States chaka chilichonse.
Ndikofunika kuzindikira kuti kafukufukuyu ali oyambirira , ndipo sitingakhale otsimikiza kuti ndi mankhwala osokoneza bongo omwe amachititsa kuchepetsa imfa .
Mwachitsanzo, pangakhale chinthu china (chosinthika) mwa anthu omwe amagwiritsira ntchito mankhwala osokoneza bongo m'malo mwake akugwirizana ndi kupulumuka kwabwino.
Ma Statins ndi Matumbo a Khansa
Kupenda kafukufuku wofalitsidwa kupyolera mu April 2015 (maphunziro 41) poyang'ana zotsatira za statins pa chiwerengero cha khansa yakufa, zikuwoneka kutsimikizira lingaliro lakuti statins ikhoza kukhudza moyo wa khansa. Maphunzirowa, omwe ali pafupi anthu miliyoni imodzi, amasonyeza kuti kugwiritsidwa ntchito kwa statins pambuyo pa matenda a khansa kukugwirizana ndi kuchepa kwa 19 peresenti pazomwe zimachititsa kuti anthu azifa komanso kuti kuchepetsa kufala kwa khansa kumapitirira 23 peresenti. Mapeto a ofufuza omwe akuyang'ana kafukufukuwa ndi akuti "kugwiritsa ntchito mafano am'mbuyo asanayambe ndi pambuyo powapeza ndi opindulitsa kuti apulumuke komanso kupulumuka mwachindunji." Ndikofunika kuzindikira kuti ngakhale khansa yamapapu imatha kumbuyo kwa maphunziro ena, ndi kafukufuku wambiri poyang'ana khansa ya m'mawere, khansara yakuda, ndi khansara ya prostate.
Zotsatira za Mafotokozedwe pa Chithandizo cha Khansa Yam'mimba
Palibe zambiri zomwe zimadziwika kuti momwe mafinya amakhudzira mankhwala omwe amachititsa khansa, koma kafukufuku wina waung'ono anapeza kuti kuwonjezera pa mankhwala monga mankhwala monga Tarceva kunachititsa kuti pakhale kusintha kwakukulu kwakupulumuka kwa anthu omwe alibe khansa ya m'mapapo yambiri. chifukwa cha kusintha kwa KRAS. Nkhaniyi ikufotokoza za kuyesa kwa kusintha kwa majini kwa anthu omwe ali ndi khansara yamapapo .
Kawirikawiri, anthu amene amayesa kusintha kwa kRAS samasintha mankhwala omwe amatchedwa epidermal growth factor receptor tyrosine kinase inhibitors ( EGFR-TKIs ). Mankhwala mumagulu awa (omwe amachiza mankhwala) omwe amagwiritsidwa ntchito mu khansa yamapapo ndi Tarceva (erlotinib) ndi Iressa (gefitinib). Mu anthu omwe ali ndi siteji 3B ndi siteji 4 ya khansa yamapapu yopanda mapira, yomwe imapangitsa kuti kusintha kwa KRAS kusinthike, kuwonjezereka kwa statin kunapitirira kuchuluka kwa kupulumuka kwapanda phindu.
Maphunziro oyambirira pa maselo a khansa ya m'mapapo a anthu amapezanso kuti kuwonjezera maselo a khansa ya m'mapapo omwe amalembedwa. Mwachidule, zimaganiziridwa kuti statin imachepa ndi isoprenoids zomwe zimakhudza RAS - choncho zimakhala zooneka pa maselo a khansa yamapapo ndi kusintha kwa KRAS.
Statins ndi Mapulogalamu a Khansa Kupewa
Ngakhale kuti kafukufuku wakale wakale sanapeze chiyanjano pakati pa katetezedwe ka khansa ndi mapapu, kufufuza kwaposachedwapa ku Taiwan kunasonyeza kuti pali mwayi wokha, makamaka kwa amayi, makamaka omwe ali ndi ziwalo zina zotupa monga COPD ndi chifuwa cha TB . Ofufuza anayerekezera amayi opitirira 17,000 opanda khansara yamapapu ndi amayi oposa 17,000 amene anapezeka ndi khansa ya m'mapapo pakati pa 2005 ndi 2010. Kugwiritsa ntchito kwa Zocor (simvastatin) kwa nthawi yaitali kunagwirizanitsa ndi 20 peresenti yochepa ya khansa ya m'mapapo poyerekeza ndi amayi omwe sankagwiritsa ntchito mankhwala. Kugwiritsidwa ntchito kwa nthawi yaitali kwa Mevacor (lovastatin) sikunali kotere, koyambitsa matendawa.
Phunzirani za kutsutsana kwaposachedwapa zokhudza kugwiritsa ntchito statins kwa akazi .
Kodi Muyenera Kuchita Chiyani ndi Zomwe Mukudziwa?
Monga tafotokozera pamwambapa, kafukufukuyu akadali akadakalipo, ndipo malangizowo okhudza agwiritsidwe ntchito ka khansa sanagwiritsidwe ntchito. Kwa iwo omwe akhala akugwiritsa ntchito mankhwala a statin ya cholesterol chokwera pa chithandizo cha khansa yamapapo, maphunzirowa angakhale othandizira. Mwinanso mungakonde kukambirana za vuto lanu kuphatikizapo mbiri yanu yamakalata ndi wanu wa oncologist ndikumufunsa zomwe akuganiza zokhudza chidziwitso ichi.
Lusoli likubweranso nthawi yomwe malangizo oyambirira pa cholesterol akufunsidwa. Mu December wa 2014, chikalata cholembera za Komiti Yowunikira Zowonjezera Zakudya Chakudya chinanena kuti cholesterol cha zakudya sichikuonanso kuti ndi zakudya zambiri zomwe zimadetsa nkhawa kwambiri. Izi ndizomwe zikuyenera kukambidwa ndikudziwikiratu pakati pa inu ndi oncologist wanu.
Zotsatira Zotsatira
Pali zinthu zina zosavuta zomwe anthu angachite kuti apulumuke ndi khansa yamapapo. Onetsetsani izi 10 zomwe zingakuthandizeni kuti mupulumutsidwe ndi khansa ya m'mapapo .
Zotsatira
Cardwell, C, McMenamin, U., Hughes, C., ndi L. Murray. Kugwiritsa ntchito Statin ndi Kupulumuka ku khansa ya m'mimba: Phunziro la Ogwirizanitsa Anthu. Khansa Epidemiology Zida ndi Kupewa . 2015. 24 (5): 833-41.
Chen, J. et al. Atorvastatin imatha kugonjetsa gefitinib kumenyana ndi maselo a KRAS osakhala ang'onoang'ono a maselo a carcinoma maselo. Imfa Imfa ndi Matenda . 2013 Sep 26: 4: e814.
Cheng, M., Chiu, H., Ho. S., ndi C. Yang. Kugwiritsira ntchito Statin ndi chiopsezo cha khansa ya m'mapapo yazimayi: phunziro lodziwika ndi anthu. Khansa Yam'mimba . 2012. 75 (3): 275-9.
Fiala, O., Pesek, M., Finek, J., Minarik, M., Benesova, L., Bortlicek, Z., ndi O. Topolcan. Ma Statins amawonjezera mphamvu za EGFR-TKIs kwa odwala omwe ali ndi kansa yapamwamba yopanda maselo omwe amatha kusinthana ndi KRAS. Matenda Achilengedwe . 2015 Feb 22. (Epub patsogolo pa kusindikiza)
Park, I., Kim., J., Jumg, J., ndi J. Han. Lovastatin imatha kugonjetsa gefitinib ku maselo osakani aang'ono omwe ali ndi khansa yamapiko ndi kusintha kwa K-Ras. Mankhwala Osokoneza Bongo . 2010. 28 (6): 791-9.
Yang, T., Lin, W., Lin, C., Sung, F., ndi C. Kao. Mgwirizano pakati pa kugwiritsira ntchito simvastatin ndi lovastatin ndi ngozi ya khansa ya m'mapapo: kuphunzirira kudziko lonse. International Journal of Clinical Practice . 2015. 69 (5): 571-6.
Zhong, S., Zhang, X., Chen., L., Ma, T., Tang, J., ndi J. Zhao. Kugwiritsira ntchito komanso kufa kwa statin mu odwala khansa: Kuwonetsa ndondomeko ndi kufufuza momwe maphunziro akuyendera. Ndemanga za Chithandizo cha Khansa . 2015 Apr 11. (Epub patsogolo pa kusindikiza)