Matenda a nyamakazi ndi matenda aakulu, amadzimadzimadzi, amadzimadzimadzi, otupa nyamakazi . Palibe mayeso amodzi omwe amatsimikizira kuti matenda a nyamakazi amawoneka. Izi zinati, vuto lopaka magazi limakhala limodzi mwa njira zomwe zimagwiritsidwa ntchito pozindikira matenda. Chifuwa chachikulu cha nyamakazi chinadziwika m'ma 1940. Zaka zaposachedwapa, mayesero ena omwe amadziwika kuti anti-CCP (anti-cyclic citrullinated antibody peptide antibody) adapezeka kuti ndi othandiza kwambiri kumayambiriro kwa matendawa.
Ma Autoantibodies Ogwirizana ndi Kuteteza Kwambiri
Chifuwa chachikulu ndi autoantibody, kawirikawiri IgM, yomwe imamanga ku Fc dera la IgG. Maantiantibodies ndi mapuloteni omwe amapangidwa ndi chitetezo cha mthupi , koma amachititsa molakwika ziwalo za thupi m'malo mogonjetsa zinthu zakunja. Kukhalapo kwa mmodzi kapena onse awiri a carantibodies, kachirombo ka rhumat, ndi anti-CCP, amatchulidwa ngati seropositivity kapena mankhwala osakanikirana a nyamakazi. Kulephera kwa magalimoto awiriwa m'magazi am'thupi kumatchedwa seronegativity kapena serometer's rheumatoid arthritis. Pafupifupi 80% a odwala matenda a nyamakazi ndi osaphatikizapo chifukwa cha chifuwa chachikulu. Pafupifupi 70 peresenti ya odwala matenda a nyamakazi ndi ofanana ndi anti-CCP.
Kusiyanasiyana kwa Matenda Kuchuluka
Zakhala zikufotokozedwa, pogwiritsa ntchito maphunziro a zachipatala, kuti odwala omwe ali ndi nyamakazi yodwala matendawa amayamba kudwala kwambiri ndi matenda, komanso kuwonetsa koopsa kuposa odwala omwe ali ndi nyamakazi.
Zikuwoneka kuti odwala osasokonezekawa amafunikira chithandizo chokwanira, koma maganizo amenewo akuwoneka ophweka kwambiri. Ndipotu, mndandanda wa seronegativity ukhoza kusocheretsa.
Wodwala amene amadziwika ngati seronegative akhoza kukhala ndi autoantibodies omwe poyamba anali otsika kwambiri kuti azindikire.
Mwachidziwitso, chigawo cholondola cha izo chidzakhala "chosadziwika kapena chosadziwika cha seropositivity". Pakhoza kukhalanso ndi magulu ena omwe amagwiritsa ntchito masewera omwe sanayambe kuyesedwa nthawi zonse. Mwachitsanzo, kuwonjezera pa anti-CCP ndi chifuwa chachikulu, maantiantibodies odziwika kuti anti-CarP (anti-carbamylated protein) akhoza kukhalapo zaka zisanachitike kuti nyamakazi imapezeka. Anti-CarP ikuwoneka kuti ilipo pafupifupi 45% ya odwala nyamakazi ya amfumbata, komanso 16% a odwala nyamakazi odwala matenda a chifuwa omwe ali olakwika chifukwa cha anti-CCP. Kukhalapo kwa antiCarP kunenedwa kuti kuneneratu kuti matenda oopsa kwambiri a nyamakazi. Choncho, odwala opatsirana pogwiritsa ntchito mankhwalawa akhoza kukhala ndi matenda kapena matenda omwe amakhala odwala kwambiri ndipo akhoza kuwayankha bwino (mwachitsanzo, DMARD kapena mankhwala osokoneza bongo ).
Kodi Siripositivity Yakhazikitsa Matenda a Matenda a Khunyu?
N'zotheka kukhala ndi zotsatira zolakwika chifukwa cha chifuwa chachikulu ndi anti-CCP, koma amapezeka kuti ali ndi nyamakazi. Malingana ndi 2010 ACR / EULAR Maphunziro Otsatira a Rhumum Arthritis, chiwerengero cha 6 pa khumi chikugwirizana ndi matenda a nyamakazi. Kuphatikizana pamodzi , kuyesera kwa serologic, pulogalamu yapamwamba ya reactants, ndi nthawi ya zizindikiro zonse zimagwiritsidwa ntchito mu dongosololi.
Mofananamo, wodwalayo akhoza kukhala ndi vuto la chifuwa chachikulu ndipo sangapezeke ndi matenda a nyamakazi. Zina zomwe zingakhale zothandiza pa chifuwa chachikulu ndi:
- Sjogren's syndrome
- Mapulaneti lupus erythematosus
- Scleroderma
- Polymyositis
- Dermatomyositis
- Matenda Osakanikirana a Matenda Aakulu
- Matenda ena
Matenda a anti-CCP sanapezeke pafupipafupi pa matenda ena. Anti-CCP imalingaliridwa kwambiri kuposa chifuwa chachikulu chothandizira kupeza nyamakazi ya nyamakazi.
Zotsatira:
Matenda a anti-carbamylated (anti-CarP) amayamba kutsogolo kwa nyamakazi ya nyamakazi. Shi J. et al. Annals wa Rheumatic Diseases. 2014 April; 73 (4): 780-3.
http://www.ncbi.nlm.nih.gov/pubmed/24336334
Kuyeza kwa anti-CCP kupimiritsa munthu ngati chida chozindikiritsa ndi kulengeza mu nyamakazi ya nyamakazi. Niewold TB ndi al. QJM. 2007 April; 100 (4): 193-201.
http://www.ncbi.nlm.nih.gov/pubmed/17434910
Matenda a Matenda a Matenda: Matenda a Seronegative ndi Asowetsedwe: Osiyana Koma Osiyana? Ajeganova ndi Huizinga. Chilengedwe Maphunziro Rheumatology. 11, 8-9 (2015).
http://www.nature.com/nrrheum/journal/v11/n1/full/nrrheum.2014.194.html
Kelley's Textbook ya Rheumatology. Chaputala 69. Etiology ndi Pathogenesis ya Matenda a Matenda a Nyamakazi. Gary S. Firestein. Kusindikiza kwachisanu ndi chinayi.