Chiyesochi chimayambitsa autoantibodies zomwe zimathandiza kutsimikizira kuti matendawa ndi otani
Mayeso a anti-CCP amagwiritsidwa ntchito kuti azindikire antantiantibodies ndi kuthandiza kusiyanitsa pakati pa nyamakazi ya nyamakazi ndi mitundu ina yotupa ya nyamakazi . Mankhwala otchedwa cyclic citrullinated peptide (CCP) antibody ndi autoantibody motsutsana ndi mapuloteni otetezedwa (ACPA) ndipo amayesedwa ndi mayesowa.
Mayesowa ali ndi mphamvu yeniyeni yodwala nyamakazi , yomwe imakhala pakati pa 50 ndi 75 peresenti.
Ilinso ndipamwamba kwambiri pamatenda a nyamakazi oposa 90 peresenti. Zomwe zili pamwambazi ndichifukwa chake mayeso a anti-CCP akhala mbali yofunika kwambiri ya matenda opatsirana a nyamakazi.
Chizindikiro cha Anti-CCP Choyesera ndi Kuyeza
Kuphatikizapo kusiyanitsa pakati pa kutupa kwa nyamakazi , kuyesa anti-CCP ndipadera kwambiri pozindikira anthu omwe ali seronegative chifukwa cha chifuwa chachikulu . Sikuti mchitidwe wotsutsa-CCP uli ndi chiwerengero chodziŵika (kumatsimikizira kuti muli ndi chikhalidwe chiti), umakhalanso ndi chidziwitso (kulongosola momwe mumayendera).
Ngati anti-CCP ilipo pang'onopang'ono mpaka kumtunda, sizingathandize kutsimikizira kuti matendawa ndi otani, amasonyeza kuti pangakhale njira yowononga komanso yoopsa kwambiri, monga kuwonongeka kwa mgwirizano. Mawerengero otsika a anti-nthenda sikuti akuwuza kapena kulosera.
Kawirikawiri, mayeso oletsa anti-CCP amalamulidwa pamodzi ndi mayeso a chifuwa chachikulu, chifukwa palibe mayesero okha omwe angatsimikizire kuti ali ndi nyamakazi.
Malinga ndi katswiri wa mafupa a zinyama, Scott J. Zashin, "Ngakhale kuti vuto la chifuwa chachikulu ndilofala kwambiri kwa anthu omwe ali ndi matenda a nyamakazi, pali anthu omwe ali ndi vuto la matenda a chifuwa chachikulu omwe alibe chifuwa chachikulu cha nyamakazi. Komanso, kukhalapo kwa chifuwa chachikulu kumakhala kochepa kwambiri kuposa ACPA.
Komanso, ngati munthu ali ndi vuto la chifuwa chachikulu, sangathe kukhala ndi vuto la ACPA. "
Kudziwa Autoantibodies
Kufunika kozindikiritsa antantiantibodies mu matenda a rheumatic kwadzidzidzidwa kwa zaka makumi ambiri, koma kuzindikira zomwe zinali zofunikira pazinthu zenizeni komanso zokhudzidwa zinatenga nthawi. Pakhala pali mibadwo itatu ya mayeso otsutsa-CCP. Ndi mbadwo uliwonse wa kuyesa zenizeni ndi zokhudzidwa zakhala bwino.
Malingana ndi "Kelley's Textbook of Rheumatology," anthu oposa 90 pa 100 alionse omwe ali ndi nyamakazi yosayerekezereka omwe amayesa kuti anti-CCP ikhale ndi nyamakazi m'thupi mwa zaka zitatu. Pafupifupi 25 peresenti ya anthu omwe ali ndi nyamakazi yosayanjanitsika omwe amayesa kuti aletse anti-CCP amayamba nyamakazi.
Maantiantibobodies amatha kupezeka asanayambe kuchipatala matenda enaake, kuphatikizapo matenda a nyamakazi. Maantiantibodies angayambitse kuyamba kwa nyamakazi ya nyamakazi yowopsa kwambiri kwa zaka ziwiri mpaka zisanu, malinga ndi "Kelley's Textbook of Rheumatology." Zimanenedwa kuti zotsutsana ndi CCP zisanachitike kuti matenda a nyamakazi amatha kudziwika kaŵirikaŵiri monga kachilombo ka HIV kamene kamapezeka kale.
Ngakhale kuti kachilombo ka khunyu kamakhala kawirikawiri, kukhalapo kwa anti-CCP kumasiyana ndi odwala nyamakazi ya nyamakazi-ngakhale kutaya nthawi zina.
Kufunika kwa Anti-CCP
Ochita kafukufuku akupitiriza kuyang'ana zomwe zikuchitika m'thupi kuti apange mamolekyu (antigen) omwe amachititsa kupanga anti-CCP antibodies. Iwo amatchedwa autoantigens chifukwa amapangidwa ndi kuwonongeka kwa zigawo zikuluzikulu m'thupi kusiyana ndi kubwera kuchokera kunja kwa thupi. Mavitamini a Peptidylarginine deiminase (PAD), omwe amachititsa kuti peptidylarginine isinthe peptidylcitrulline, amathandizira kwambiri kupanga maantiantigens mu nyamakazi ya nyamakazi.
Komanso, kafufuzidwe kafukufuku amafunika kudziwa chomwe chimachititsa kuti matenda a nyamakazi asanatuluke kuti ayambe kudwala matenda oopsa kwambiri.
Ngakhale kuti anti-CCP ndi yeniyeni yeniyeni yodwala nyamakazi, zotsatira zabwino zingakhalepo ndi matenda ena ozunguza bongo, chifuwa chachikulu, ndi matenda aakulu a mapapu. Mankhwala a anti-CCP adziwika mu systemic lupus erythematosus ndi matenda a Sjogren oyambirira, makamaka pamene matenda a nyamakazi alipo. Zapezeka kuti mwa anthu 16 pa anthu 100 aliwonse omwe ali ndi nyamakazi ya psoriatic -nthawi zambiri ndi odwala kapena a polyarthritis . Nthawi zina, zimakhala ndi psoriasis yovuta popanda nyamakazi.
> Zotsatira:
> Kushi JJ, Kavanaugh A, Weinblatt ME. Matenda a Nyamakazi: Matenda Oyambirira ndi Chithandizo . West Islip, NY: Professional Communications; 2010.
> Firestein GS, Kelley WN. Kelleys Textbook of Rheumatology . Philadelphia, PA: Elsevier / Saunders; 2013.
> Taylor PC, Malamulo RN. Zizindikiro za Biologic mu Kufufuza ndi Kufufuza kwa Matenda a Matenda a Khunyu. Zaposachedwa. https://www.uptodate.com/contents/biologic-markers-in-the-diagnosis-and-assessment-of-rheumatoid-arthritis.