Chidule chakumeneko - Kumvetsetsa zotsatira za kuyesedwa

Zina mwa Zoyesedwa Zoyamba Pamene Chifuwa cha Matenda a Mthempha Chimayesedwa

Chifuwa chachikulu ndi autoantibody (kawirikawiri IgM) yomwe imamangiriza ku Fc dera la antigog. Maantiantibodies ndi mapuloteni omwe amapangidwa ndi chitetezo cha mthupi , koma m'malo mogonjetsa zinthu zakunja, amamenyana ndi matupi awo. Ngati dokotala akudandaula kuti mukhoza kukhala ndi nyamakazi , chiyeso cha mankhwalawa chidzakhala chimodzi mwa mayesero oyambirira omwe amachitidwa.

Njira zoyambirira zowonetsera kuti maantiantibodies amathandizidwa ndi nyamakazi ya nyamakazi inayamba m'ma 1940. Kumayambiriro kwa izi, izi zinali zowonongeka kwambiri zomwe seramu ya odwala nyamakazi yodwala nyamakazi imapezeka kuti imayambitsa maselo ofiira a magazi omwe amathandizidwa ndi akalulu odana ndi nkhosa. Panali kusintha kochulukira kwa mayeso oyambirira a agglutination, makamaka kulowetsa mikwingwirima yothandizira maselo a nkhosa. Pambuyo pake, mayeso a ELISA (immunosorbent assay) omwe anagwiritsidwa ntchito poyambitsa mavitamini, anayamba kuyesedwa, komanso mayesero a nephelometry.

Mu mayesero a agglutination, kugumula ndikulongosola zotsatira zabwino. Zithunzi zamagetsi zimatha kupangidwa ndi test test pofuna kudziwa titer. Mutuwu umasonyeza momwe zitsanzo zingathe kuchepetsedwa chisanafike poyerekeza ndi chifuwa chachikulu (sichikudziwika).

Mu mayeso a nephelometry, nyemba ya magazi imasakanizidwa ndi ma antibodies kuti ayambitse.

Kuwala kumadutsa kupyolera mu zitsanzo kuti mudziwe kuchuluka kwa msanga.

Kumvetsa Zotsatira

Kawirikawiri, kawirikawiri kayezetsedwe kake kameneka kali ngati:

• Pansi pa 40-60 u / mL
• Pansi pa 1:80 (titeri)

_{Zindikirani: Ma laboratories osiyanasiyana amasiyana ndi njira yogwiritsira ntchito kapena katayi yogwiritsira ntchito, motero tsatirani zotsatira ndi machitidwe abwino omwe amaperekedwa ndi labotayi.}

Zotsatira za mayesero a chifuwachi zimatha kusokoneza odwala nyamakazi. Choyamba, chinthu chofunikira kwambiri kudziwa kuti vuto la chifuwa chachikulu ndi chidziwitso chimodzi chokha chimene chimagwiritsidwa ntchito poyambitsa matenda. Chodziwikiratu chodziwika bwino sichinazikidwe kokha pa zotsatira za mayeso a chifuwachi. Nazi zina zofunikira pa yeseso ​​ya chidziwitso chimene muyenera kudziwa:

• Chifuwa chachikulu chikhoza kukhala chonchi kwa anthu abwino (1 peresenti ya achinyamata ndi 5% mwa iwo oposa zaka 70).
• Matenda a chifuwa chachikulu akhoza kukhala abwino m'matenda osagwidwa ndi matenda a nyamakazi (monga matenda, khansara) kapena mu rheumatic mikhalidwe osati nthenda yamagazi (mwachitsanzo, Sjogren's syndrome kapena lupus ).
• Chifuwa chachikulu cha magazi chikhoza kudziwika m'magazi mpaka zaka khumi zisanachitike zizindikiro za nyamakazi zimayambira. Komabe, mu chigawo chimodzi cha odwala nyamakazi, nyamakazi imapezeka ngati zizindikiro zikuwonekera.
• Odwala nyamakazi odwala matenda a nyamakazi omwe ali ndi kachilombo ka HIV amayamba kukhala ndi matenda oopsa, pamene odwala omwe ali ndi vuto la chifuwa chachikulu (matendawa) amakhala ndi matenda ochepa kwambiri komanso amachepa osachepera.
• Pafupifupi 20 peresenti ya anthu omwe amapezeka ndi matenda a nyamakazi amakhalabe osowa chifukwa cha matendawa.

Kufunika kwachipatala cha zotsatira

Chotsatira cha chidziwitso cha matenda a chifuwa chachikulu chimene chimakhala choyipa poyamba chikhoza kusintha, koma kufunika kwa kachipatalako kumakhalabe kovuta. Malinga ndi Scott Zashin, MD, katswiri wa matenda ozunguza matenda a nyamakazi kuchokera ku Dallas, ku Texas (scottzashinmd.com) ndi mlembi wa Arthritis Osapweteka - Chozizwitsa cha TNF Blockers ndi wolemba wina wa buku langa lachiwiri la Natural Arthritis Treatment , " Othandiza anthu kuti asamatsatire chifuwa chachikulu Izi zimati, zomwe ndikudziwa, kuchuluka kwa chifuwa chachikulu cha matendawa kungasinthe kwambiri ndi matenda , koma sizomwe zimagwiritsidwa ntchito pokhapokha ngati zowonongeka, monga chiwerengero cha erythrocyte sedimentation , C- mapuloteni othandizira kwambiri (CRP) , ndipo nthawi zina zizindikiro zina zomwe zingapeze muyezo wa VECTRA , womwe umagwiritsidwa ntchito poyeza matenda odwala nyamakazi. "

_Zotsatira:

_{Kelley's Textbook ya Rheumatology. Kusindikiza Kwachisanu ndi Chinayi. Autoantibodies mu Chifuwa cha Matenda a Nyamakazi. Mutu 56. Felipe Andrade et al. p. 804.}

_{Choyamba pa Rheumatic Diseases. Gulu lachitatu. Lofalitsidwa ndi Arthritis Foundation. Mutu 6. Chifuwa cha Matenda a Nyamakazi. Zinthu Zopangira Mafupa. p. 126.}

_{Chidule cha Rheumatoid (RF). MedlinePlus. Kusinthidwa 4/20/2013.
https://www.nlm.nih.gov/medlineplus/ency/article/003548.htm}