Odwala omwe ali ndi matenda ochititsa munthu kusinthasintha zochitika nthawi zambiri amadabwa pozindikira kuti vuto la chithokomiro ndilochizolowezi chotsatira mankhwalawa. Lithiamu ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda ochititsa munthu kusinthasintha zochitika, omwe nthawi zina amatchedwa kuvutika maganizo.
Lithiamu imakhala ndi zotsatira zambiri pa chithokomiro:
- imachepetsa mphamvu yanu ya chithokomiro yotulutsa thyroxine (T4)
- Zimasokoneza kutembenuka kwa T4 mpaka T3
- Ikhoza kuyambitsa kuwonjezeka kwa msinkhu wa TSH
- zikhoza kuvulaza matenda aakulu a chithokomiro
Lithium imadziwika kuti imayambitsa goitis (chithokomiro chofutukuka), komanso hypothyroidism (chithokomiro chosagwiritsidwa ntchito), komanso chithokomiro chosawonongeka cha thyroiditis, matenda otentha a chithokomiro. Palinso mgwirizano pakati pa lithiamu ndi hyperthyroidism mwa odwala ena.
Matenda Okhudzana ndi Chithokomiro a Lithium
Goiter: Goiter , chithokomiro chowonjezera cha chithokomiro, ndilo mbali yowonjezera ya chithokomiro ya lithiamu, ndipo akuti akupezeka pafupifupi pafupifupi theka la odwala onse omwe amachitidwa ndi lithiamu. Nthawi zambiri goiter imafika mkati mwa zaka ziwiri zoyambirira za mankhwala a lithiamu. Ndi chithokomiro chotchedwa lithium-induced goiter, chithokomiro chanu chitha kuwonjezera kukula kwake kawiri kukula kwake.
Hypothyroidism: Tizilombo toyambitsa matenda, timadzi timene timatulutsa timadzi timene timatulutsa timadzi timene timatulutsa timadzi timene timatulutsa timadzi timene timatulutsa timadzi timene timayambira .
Nthawi zambiri mumapezeka zaka ziwiri zoyambirira za mankhwala anu a lithiamu. Azimayi opitirira 45 ali pangozi yaikulu ya lithiamu-induced hypothyroidism, ndipo chiopsezo chachikulu cha hypothyroidism kwa odwala omwe ali ndi lithiamu amakula ndi msinkhu.
The hypothyroidism ikhoza kukhala yeniyeni-ndi nthenda yakutali yowonongeka ya hormone (TSH), ndi timene T4 ndi T3 aliwonse-ndi zizindikiro zochepa.
Nthaŵi zina, hypothyroidism ndi yofatsa, ndipo imakhala mkati mwa miyezi ingapo yoyambirira ya mankhwala a lithiamu, koma ndi yachangu, ndipo chithokomiro chimabwerera kwachibadwa. Komabe, ochepa peresenti ya odwala, amakhala ndi mavitamini ambiri, omwe ali ndi zizindikiro ndi zizindikiro . Odwalawa ayenera kupatsidwa mankhwala a lithiamu-induced hypothyroidism .
Kusamalitsa Chithokomiro Chanu: Odwala omwe amatenga lithiamu amakhalanso pachiopsezo chokhala ndi autoimmune thyroiditis-kutentha kotentha kwa chithokomiro cha chithokomiro. Ngati mukuyamba lithiamu mankhwala, kukhalapo kwa mankhwala otchedwa antithyroid antibodies (chithokomiro cha peroxidase TPO antibodies) - ngakhale popanda chithokomiro chosawonongeka - chimakuika pachiopsezo chachikulu chokhala ndi vuto la chithokomiro pamene muli ndi lithiamu. Apo zikuwonekeranso kuti pali umboni wina wakuti lithium yokha ingayambitse ma antibodies apamwamba ndi kuyamba kwa matenda a chithokomiro osadziwika mwa odwala ena.
Mankhwalawa amaoneka kuti akugwirizanitsidwa ndi chiopsezo chowonjezeka cha hyperthyroidism -modzinso mahomoni ambiri a chithokomiro. Kafukufuku wambiri wasonyeza kuti hyperthyroidism imakhala yofala kwambiri kwa odwala omwe ali ndi lithiamu, poyerekeza ndi kuchuluka kwa anthu ambiri.
Kodi Ayenera Kuchita Zotani?
UpToDate ili ndi malangizo ena othandizira odwala kutenga lithiamu kumvetsa zotsatira zokhudzana ndi chithokomiro:
Chifukwa cha kuchuluka kwa goiter ndi hypothyroidism zomwe zimachitika pa chithandizo cha lithiamu, odwala ayenera kuyang'anitsitsa chithokomiro ndi kutsimikiza kwa seramu TSH ndi antithyroid anti antibody mankhwala asanayambe chithandizo cha lithiamu. Odwala omwe ali ndi chithokomiro choyenera pa nthawi imeneyo ayenera kuyambiranso kuyambiranso miyezi isanu ndi umodzi kapena 12 kwa zaka zingapo. Ngati chithokomiro chimagwira ntchito mopitirira malire poyesa koyambirira, lithiamu ikhoza kuperekedwabe ngati kuli koyenera koma chithokomiro chosafunika chiyenera kuchiritsidwa.
Izi zikutanthawuza kuti ngati mwauzidwa kuti lithiamu, muyenera kuonetsetsa kuti mukuyezetsa chithandizo cha chithokomiro , komanso kuyesa magazi kuti muyese ma ARVs kuti muyese ma ARV , musanayambe mankhwala a lithiamu. Akatswiri ena amalimbikitsanso kukhala ndi chithokomiro patatha masabata asanu ndi limodzi mutayamba kumwa mankhwala a lithiamu. Malingana ngati mutenga mankhwala a lithiamu, dokotala wanu ayenera kuyambiranso ntchito yanu ya chithokomiro, kuphatikizapo kuyezetsa magazi ndi kuyezetsa magazi, miyezi isanu ndi umodzi kapena 12, kapena poyamba, ngati mutayamba kusonyeza zizindikiro zomwe zimasonyeza kuti muli ndi vuto la chithokomiro.
Mankhwala otchedwa Lithium -ducedduced hypothyroidism amatha kusintha ngati mutasiya kumwa lithiamu. Ngati mumayambitsa vuto la chithokomiro pamene muli ndi lithiamu mankhwala, akatswiri samalimbikitsa kusiya mankhwala anu a lithiamu. Mmalo mwake, iwo ndi ofunika ndikugwira ntchito ndi dokotala kuti muwone kuti mukupeza chithandizo choyenera cha chithokomiro chanu . Dokotala wanu adzafunika kuyang'anira chithokomiro chanu ndi momwe mungayankhire kuchipatala kuti muwonetsetse kuti mukuchiritsidwa, ndipo nthawi zonse muwone ngati kupitiriza ndi lithiamu mankhwala ndiko njira yabwino yathanzi lanu.
Chitsime:
> Goldberg, Joseph, MD. "Kulamulira kwa Hypothyroidism kwa Odwala pa Lithium Prophylaxis kwa Matenda a Bipolar." Kusaka. October 31, 2008. Online: http://www.medscape.com/viewarticle/581200
> Surks, Martin. "Lithiamu ndi chithokomiro." Zaposachedwa. Kupezeka: March 2009.