Kutenga masewera ndi kuzigwiritsa ntchito ku zolinga zenizeni za moyo ndi ntchito, chinachake chomwe chimadziwika kuti "kujambulitsa," chikupita patsogolo pa liwiro la chiwombankhanga chifukwa cha dziko lathu lamagetsi-mafoni. Kuyanjanitsa kwadutsa m'madera osiyanasiyana kuphatikizapo masewera olimbitsa thupi, masewera olimbikitsa kusintha kwa moyo, komanso masewera olimbikitsa kukwaniritsa zolinga za ntchito.
Genentech, kampani yotsogoleredwa ndi biopharmaceutical, tsopano akusewera sayansi kumbuyo kwa chithandizo cha khansa-ndipo sali okha. Koma bwanji kugwiritsidwa ntchito kumakhudzana ndi odwala khansa? Chabwino, kwa wodwala ndi khansa, kuyesera kukonzekera zam'tsogolo kungakhale kovuta. Sayansi ya sayansi, mawu apadera, zidule, ndi zilembo siziwathandiza. Mwachitsanzo, nthawi za kupulumuka zimatha kuwerengedwa m'njira zosiyanasiyana, komanso momwe wodwalayo angayankhire mankhwala. Ndiko Mission: MRD ikulowamo.
Mission: MRD
Genentech yakhazikitsa masewera atsopano a masewera 60, Mission: MRD, kuphunzitsa anthu za matenda ochepa omwe amagwiritsidwa ntchito (MRD) - njira yowunikira yankho la munthu ku matenda opatsirana khansa kapena regimen.
Mitundu yambiri ya kansa yamagazi- kuphatikizapo matenda a khansa ya m'magazi (CLL), yomwe imakhala yowopsa kwambiri ya khansa ya m'magazi-ndiyo mitundu yomwe imayenera kulamulidwa ndi mankhwala oletsa khansa pa nthawi, kutanthauza kuti simungathe kuchotseratu maselo onse a khansa.
Izi zimayambitsa kubwereza, kotero madokotala amayesa kukhala osamala kwambiri pa mawu akuti "mankhwala."
Mu Mission: MRD, wogwiritsa ntchito kudzera m'magazi, kuwononga maselo ambiri a khansa monga momwe angathere ndi cholinga chofikira kusagwirizana kwa MRD. Ndikofunika kuzindikira kuti masewerawa ndiwasangalatsedwe osati kuti azitha kulandira mankhwala kapena zokhudzana ndi sayansi, koma kuti adziwitse za mtundu wa MRD.
MRD-Kusagwirizana
Munthu wina amene ali ndi CLL akafika ku MCD-kusayanjanitsika, zikutanthauza kuti palibe maselo a khansa angapezedwe m'magazi amagazi kapena mafupa pogwiritsa ntchito mayesero. Tsopano, chifukwa cha khansa ngati CLL, nkuthekabe kuti matendawa abwerere, ngakhale atakhala wodwala a MRD-kusagwirizana; Komabe, kukwaniritsa kuperewera kwa MRD kumawoneka kuti ndi chinthu chabwino ndipo ndi chifukwa chake:
- Pali njira zingapo zothetsera matenda omwe ali ndi khansa. Udindo wa MRD mu CLL wapangidwa ndi makompyuta atsopano, ovuta kwambiri.
- Munthu wina yemwe ali ndi CLL akafika ku MCD-kusayanjanitsika, amatanthauza kuti palibe khansara yomwe imapezeka muzigawo zamagazi kapena mafupa pogwiritsa ntchito mayesero omwe amagwiritsa ntchito njira zowonongeka kuposa njira zakale zowerengera maselo 100 pa microscope.
- Kulephera kwa MRD kungagwirizane ndi zotsatira zabwino. Ntchito yambiri imayenera kuchitidwa koma umboni wochulukirapo umasonyeza kuti MRD-kusayanjanitsika pambuyo pa mankhwala ena amatha kudziwiratu kuti nthawi yayitali idzachotsedwa komanso mwina nthawi yochulukirapo ya khansa yambiri ya magazi.
Masewera a khansa amtsogolo
Masewera ena amakonzedweratu ndipo mafano ndi zofotokozera zosiyanasiyana zimapezeka pa webusaiti ya Genentech kukuthandizani kumvetsetsa kayendedwe ka chitetezo cha khansa - njira yomwe imatsogolera ku chitukuko cha chitetezo cha mthupi ku maselo a khansa.
Zotsatira:
Smolej L, Šimkovič M. Kugwiritsa ntchito njira zoyang'anira odwala matenda aakulu a khansa ya m'magazi. Archives of Medical Science: AMS. 2016; 12 (2): 448-456.
Hallek M, Cheson BD, Catovsky D, et al. Malangizo othandizira kupeza matenda ndi matenda a chronic lymphocytic leukemia: lipoti lochokera ku International Workshop pa Chronic Lymphocytic Leukemia kukonzanso National Cancer Institute-Working Group 1996 malangizo. Magazi . 2008; 111: 5446-56.
Hallek M, Fischer K, Fingerle-Rowson G, et al. Kuonjezeredwa kwa rituximab ku fludarabine ndi cyclophosphamide kwa odwala omwe ali ndi matenda aakulu a khansa ya m'magazi: tsamba lodziwika bwino, lotseguka, yesero lachitatu. Lancet. 2010; 376: 1164-74.
Bottcher S, Ritgen M, Fischer K, et al. Kuchepetsa kuchepa kwa matendawa ndi kudziimira payekha komanso kupulumuka kwa matenda aakulu a khansa ya m'magazi: kutengera kwa multivariate kuchokera ku mayeso omwe ali ndi GCLLSG CLL8. J Clin Oncol . 2012; 30: 980-8.