Pali magulu awiri akuluakulu a nyamakazi, yotupa nyamakazi. Oyamba, osteoarthritis , amawoneka kuti ndi zotsatira zosalephereka zogwedezeka pa okalamba kapena pambuyo povulala. Chachiwiri ndi nyamakazi yotupa yokha, imene nyamakazi yamatenda (RA) imapezeka kwambiri. Mu RA, maselo a chitetezo cha mthupi ndi amithenga awo otulutsidwa (cytokines ndi chitsanzo chimodzi), athane ndi minofu mkati mwa ziwalo zomwe zimayambitsa kutupa.
Zonsezi zingayambitse kuwonongeka pamodzi ndi kuwonongeka pakati pathu-kotero kuti zimakhudza moyo wa anthu. Koma ngati muli ndi nyamakazi, mwinamwake mumadziŵika bwino ndi gawo lotsiriza limenelo. Chimene sichikudziwika kwa inu, komatu, kuti mitundu yonse ya nyamakazi imakhudza chinachake chotchedwa kupopera kwa okosijeni m'magulu-ndipo izi zimayambitsa kuwonongeka kwa mgwirizano ndi chinthu chimene mungakhudze.
Kumvetsa Kupanikizika Kwambiri
Kupanikizika kwapadera ndi njira yachibadwa yomwe imachokera kuntchito ya tsiku ndi tsiku. Pamene maselo anu amachita ntchito yawo, amapanga zinthu zowonjezera, zomwe ndikuganiza kuti ndi "zotchetche" kapena moto wamoto. Ndiye chitetezo cha thupi lanu cha antioxidant chimachotsa kunja, mofanana ndi payipi ya moto yopopera moto.
Maseŵera ochepa a kupsyinjika kwa zowopsya kwenikweni amapindulitsa pa ntchito zanu zachizoloŵezi. Chifukwa chotsitsa zida zowonongeka ndi njira yachibadwa, chilengedwe chimatipatsa kuchuluka kwa antioxidants mu chakudya chomwe timadya-mankhwala omwe amapezeka mu zipatso ndi ndiwo zamasamba-zosiyanasiyana zomwe zimayimira mitundu yonse yowala ndi yosiyanasiyana ya zakudya izi.
Tsiku lililonse, muyenera kudya zakudya zopatsa thanzi kuti mupereke thupi lanu ndi mankhwala osokoneza bongo. Komabe, ngati simubweretsa mankhwala okhudzana ndi antioxidants mu thupi lanu kuti mukhale ndi zozizwitsa zonse zomwe zimalengedwa, pamapeto pake zida zowonongeka zidzapambana, kutentha kumakhala moto ndipo moto umatulutsa kutupa, kuwonongeka kwa minofu, ndi mapeto ake.
Kupsyinjika kwa oxidative kungakhudze maselo anu omuteteza kuthupi, makamaka, chifukwa ali otanganidwa kwambiri, ndipo amalenga ndi kumasula zowonongeka momasuka pamene akugwira ntchito yawo ya tsiku ndi tsiku kukutetezani. Iyi ndi njira yomwe timakhulupirira RA ndi zina zotupa zamatenda, kuphatikizapo osteoarthritis, ikugwira ndikukula.
Connection kwa Arthritis
Kafukufuku wambiri wasonyeza kuti anthu omwe ali ndi RA ali ndi mitundu yambiri ya okosijeni yotchedwa oxygen (ROS), omwe amatha kuwononga lipids, mapuloteni, ndi DNA mu minofu.
Muzochitika zachilendo, ROS imayang'aniridwa ndi mawonekedwe osiyanasiyana a chitetezo cha antioxidant. Kwa anthu omwe ali ndi RA, komabe antioxidants sungathe kupitirizabe ndipo amawomboledwa amatha kuyendetsa amok ndikuyambitsa minofu. Pogwiritsa ntchito zida zomenyana ndi thupi lanu, chitetezo chakumapeto kwa mankhwalawa chikupitirizabe kutupa. Njira yonseyi ingathe kutsogolera mafupa, mapuloteni, ndi kanyumba kakang'ono.
Akatswiri ofunikira ku yunivesite ya Aligarh Muslim ku India anayerekezera kuvutika maganizo kwa anthu omwe anapezeka ndi RA kwa anthu omwe alibe matendawa, odwalawa anali ndi nkhawa yowonjezera, kuphatikizapo kuwonjezereka kwa ROS, kuwonongeka kwa DNA, kuwonongeka kwa antioxidant chitetezo, ndi zizindikiro zina.
Amakhalanso ndi mankhwala ochepa a antioxidants: glutathione ndi vitamini C. Glutathione mwina ndi ofunika kwambiri m'thupi chifukwa amagwira ntchito mkati mwa maselo anu kuti ateteze thupi lanu ku vuto la ROS. Chodabwitsa n'chakuti, odwala matenda a RA omwe anali ndi ululu ndi kulemala kwambiri ndipo omwe anali ndi RA yaitali kwambiri anali ndi mavuto oopsa okhudzana ndi matenda oopsa komanso ochepa kwambiri a antioxidants. Zofufuza nthawi zonse zimagwirizanitsa mgwirizano uwu pakati pa magulu apansi a antioxidants enieni ndi kuchuluka kwa zizindikiro zowonjezera kwa anthu omwe ali ndi RA.
Osteoarthritis (OA) imagwirizanitsidwa ndi kulemera kwakukulu kwa kupsyinjika kwauchivundi, nayenso. Amakhulupirira kuti anthu omwe ali olemera kapena owonjezera thupi lamthupi (mtundu wa mafuta omwe ali mkati mwa mimba yanu, kukulunga kuzungulira ziwalo zanu zamkati) ali ndi nkhawa yambiri m'matumbo awo, ndipo pali mgwirizano wamphamvu pakati pa kunenepa kwambiri ndi OA.
Zimakhulupirira kuti kupitirizabe kumawomboledwa kwaulere kumayambitsa chondrocytes (maselo omwe amapanga khungu) kuti apange mitundu yambiri ya oxygen (ROS), ndipo izi zimawononga kagale collagen ndikusintha madzi mkati mwa ziwalo mwa kuzipangitsa kukhala zochepa komanso zosatetezera. Kafukufuku amasonyeza kuti vitamini C yochepa imakhala ndi chiopsezo chachikulu cha mawondo a OA ndipo kuti kuwonjezera kudya kwanu kungapangitse OA mawondo ndi mazunzo kuti ayambe kuwonjezereka. Nkhani yabwino ndi yakuti maphunziro amasonyeza kuti kutaya mafuta thupi kumachepetsa kupweteka kumodzi ndi kutupa.
Momwe Mungachitirepo
Kugwiritsira ntchito chakudya ngati mankhwala nthawi zonse ndi njira yoyamba yochepetsera kutupa ndi kupsyinjika kwa okosijeni. Pano tikuyang'ana kukonzanso ntchito yoteteza antioxidant m'thupi lanu. Antioxidant yanu imagwiritsa ntchito michere yosiyanasiyana yothetsera vutoli, monga superoxide dismutase (SOD), ndipo mavitaminiwa amafunikira mavitamini, mchere, ndi amino acid kuti azigwira bwino ntchito zawo.
Pofuna kutulutsa mankhwala osokoneza bongo, mankhwala ophera antioxidants ndi ofunika kwambiri, ndipo awa ndi mavitamini odziwika monga beta-carotene ndi mavitamini A, E, ndi C, komanso mphamvu ya polyphenols yochulukirapo masamba ndi zipatso, komanso masamba obiriwira Muyenera kudya tsiku lililonse, ndi chakudya chilichonse.
Kuwonjezera pa kukonzanso kudya kwa antioxidants, kubwereranso ndikumachiritsa matenda a nyamakazi, muyenera kuthandizanso kuwonetsa zachilengedwe ndi zokopa zomwe zingakhale zoonjezerapo kupsyinjika kwazitsulo kwa dongosolo lanu. Zovutazi zimaphatikizapo matumbo a dysbiosis (kusintha m'matumbo a microbiome), kuwonetsa poizoni, matenda, ndi / kapena mafuta ochuluka kwambiri.
Kuchiza matumbo a microbiome ndi matope othamanga kumafufuza kwambiri monga njira yokhazikika yochizira matenda a nyamakazi chifukwa zikuwoneka kuti kupsyinjika kwa okosijeni ndi kutupa kumayamba pomwepo ndikupita kumadera akutali a thupi lanu, kuphatikizapo ziwalo zanu.
Kumbukirani, nyamakazi ndi chikhalidwe chonse, ndipo ululu umene umamva umayambitsidwa ndi kutupa ndi kupsinjika maganizo komwe kumachokera kwinakwake m'thupi lanu. Ngati mupeza ndikusamalira gweroli, mumakhala bwino popanda mankhwala. Ndipo ndicho cholinga.
Blum ndi mlembi wa "Kuchepetsa Matenda a Mitsempha," yomwe imalongosola momwe angachiritse m'matumbo ndikusamalira zomwe zimayambitsa matenda oopsa (Scribner 2017).
> Zotsatira:
> Hani M. Khojah, Sameh Ahmed, Mahran S. Abdel-Rahman, Al-Badr Hamza, Mitundu yotentha ya oxygen ndi nayitrogeni kwa odwala matenda a nyamakazi monga zida zowononga matenda komanso ntchito ya antioxidants. Biology Yovuta Kwambiri ndi Mankhwala, Voliyumu 97, August 2016.
> Mateen S, Moin S, Khan AQ, Zafar A, Fatima N (2016) Kuwonjezereka kwa Oxygen Species Formation ndi Kupanikizika kwa Oxidative mu Chifuwa cha Amuna. PLoS ONE 11 (4): e0152925. lembani: 10.1371 / magazini.pone.0152925
> Musumeci G, Aiello FC, Szychlinska MA, Di Rosa M, Castrogiovanni P, et al. (2015). Osteoarthritis m'zaka za zana la makumi awiri ndi ziwiri: zifukwa zoopsa ndi > makhalidwe > omwe amachititsa kuti matenda ayambike komanso apite patsogolo. International Journal of Molecular > Sciences, > 16 (3): 6093-112.
> CM Yamagonezi, González-Chávez SA, Del Río Nájera D, Pacheco-Tena C. Kupanikizika Kwambiri Kufunika kwa Pathogenesis ya Mthemphafu ya Nyamakazi: Kufufuza Kwambiri. BioMed Research International. 2016; 2016: 6097417. onetsani: 10.1155 / 2016/6097417