Mmene Zimagwirira Ntchito Pamodzi Zizindikiro za PCOS Monga Tsitsi Losasoweka
Matenda a Polycystic ovary ( PCOS ), matenda omwe amachititsa kuti abambo ambiri abereke, amadziwika ndi hyperandrogenism (mahomoni akuluakulu, monga testosterone) ndi opaleshoni ya ovulatory.
Zina mwa zizindikiro zovuta kwambiri zomwe amayi omwe ali nazo ndi zochitika za PCOS zimaphatikizapo tsitsi: kutaya tsitsi ndi tsitsi loposa (hirsutism). Zotsatira za kafukufuku wofalitsidwa mu PLOS One, magazini yowonetsedwa ndi anzawo, inapeza kuti hirsutism imakhudza kwambiri moyo wokhudzana ndi thanzi la amayi a ku Iran omwe amapezeka ndi PCOS.
Zotsatira za hirsutism zimatenga nthawi yochulukirapo, zimakhudza khalidwe labwino komanso kudzidalira.
Azimayi omwe ali ndi PCOS omwe amavutika chifukwa cha hirsutism akhoza kuuzidwa Flutamide, mankhwala omwe amagwira ntchito monga anti-androgen.
Momwe Flutamide Amagwirira Ntchito
Flutamide (dzina lotchuka la Eulexin), amagwira ntchito poletsa androgens, omwe ndi gulu la mahomoni omwe amathandiza nawo mchitidwe wamwamuna ndi ntchito yobereka.
70-80% ya amayi omwe ali ndi mayendedwe owonjezera amasonyeza hirsutism. Androgens amachulukitsa kukula kwa tsitsi ndi kusinthika, zabwino, zobiriwira, tsitsi la ana (tsitsi la vellus) mpaka tsitsi lakuda, lalitali, ndi lakuda. Pamene mavitomu amachepa, kukula kwatsopano kwa tsitsi kumachepetsedwa ndipo kukula kwa tsitsi lomwe lakhalapo kumachepetsedwa.
Flutamide imateteza mayendedwe a androgen pamaseĊµera opaka tsitsi ndipo ma androgens sangathe kugwirizana ndi mapuloteni. Pamene atsekedwa pamutu wa tsitsi amatsekedwa, kutayika tsitsi kwa PCOS ndi hirsutism kumachepetsa.
Izi zikhoza kuchepetsa zizindikiro za PCOS , makamaka kuwonjezeka kwa tsitsi lomwe limagwirizanitsidwa ndi PCOS, ngakhale Flutamide sichivomerezedwa ndi FDA pa ntchitoyi.
Azimayi ambiri omwe amatenga Flutamide amazindikira tsitsi locheperapo komanso tsitsi lochepa. Mbali ina ya Flutamide ndi yakuti si-steroidal ndipo imakhudza ntchito ya impso monga anti-androgens ena.
Flutamide sagwira ntchito mwamsanga. Tsitsi limakula panthawi zosiyanasiyana ndipo kukula kwake kumasiyanasiyana malinga ndi dera la thupi, kuti pakhale kukula kwathunthu, kukula kwake kumakhala pafupifupi miyezi inayi ya tsitsi la nkhope. Ichi ndichifukwa chake kulimbikitsidwa kupereka mankhwala oletsa antirojeni kuposa miyezi isanu ndi umodzi kuti agwiritse ntchito bwino.
Mlingo ndi Zotsatira Zotsatira
Mlingo wa Flutamide wa PCOS ndi 125 mg kapena masentimita 250 mg awiri kapena katatu patsiku. Chonde lembani malangizo anu a dokotala kuti mupeze mlingo woyenera wa mlingo wanu. Nthawi zonse mutsatire malangizo a dokotala musanayambe kumwa mankhwala.
Zina mwa zotsatira zofala za Flutamide ndizo:
- kugona
- kudandaula
- chisokonezo
- kutsekula m'mimba
- kunyoza
- kusanza
- kutentha kotentha
- Kutaya kwa libido
- kuthamanga
- kutupa
- khungu louma
- zilema zobereka
Izi siziri mndandanda wathunthu wa zotsatirapo ndipo ena akhoza kuchitika. Lankhulani ndi dokotala wanu ngati mukukumana ndi zotsatirapo zotsatirazi.
Malangizo Ena
Kuyezetsa magazi nthawi zonse kumalimbikitsidwa kuyesa chiwindi ndi magazi ndikuthandizira kuti asayambe kumwa Flutamide.
Ndikofunika kwambiri kuti musatenge pathupi pamene mutenga Flutamide, chifukwa cha chiopsezo kwa mwana yemwe akukula. Onetsetsani kuti mugwiritse ntchito mawonekedwe oyenerera oletsa kubereka ndipo musamamwe mkaka mukamamwa mankhwalawa.
Lembani zotsatira zosavuta zachidwi kwa dokotala wanu mwamsanga.
Zotsatira:
Ibanez L, Potau N, Marcos MV, de Zegher F. Kuchiza kwa Hirsutism, Hyperandrogenism, Gligomenorrhea, Dyslipidemia, ndi Hyperinsulinism ku Nonobese, Adolescent Girls: Zotsatira za Flutamide. J Clin Endocrinol Metab. 2000 Sep; 85 (9): 3251-5.
> Mahnaz Bahri Khomami, Fahimeh Ramezani Tehrani, Somayeh Hashemi, Maryam Farahmand, ndi Fereidoun Azizi. Za zizindikiro za PCOS, Hirsutism Ili ndi Mphamvu Yofunika Kwambiri pa Moyo wa Akazi a Irani. PLoS One. 2015; 10 (4): e0123608.
Muderris II, Bayram F, Guven M. Chithandizo cha Hirsutism Ndi Flutamide (Lowest-Dose Flutamide (62.5 mg / tsiku). Gynecol Endocrinol. 2000 Feb; 14 (1): 38-41.
Muderris II, Bayram F, Guven M. A Cholinga, Randomized Trial Poyerekeza Flutamide (250 mg / d) ndi Finasteride (5 mg / d) mu Chithandizo cha Hirsutism. Fertil Steril. 2000 May; 73 (5): 984-7.