Yang'anani ndi Gastroenterologist Yanu Musanatenge Painkiller
Yang'anani pafupi ndi mankhwala alionse a kabati ndipo mukhoza kupeza NSAID (mankhwala osagwiritsidwa ntchito poletsa kutupa). NSAIDs, zomwe zimagwiritsidwa ntchito pochiza ululu ndi kutupa, zimakhala zofala kwambiri moti nthawi zambiri amakhala ndi kanjira yawo m'masitolo ogulitsa mankhwala. Ndipotu, chisamaliro chiyenera kuchitidwa kuti anthu asatengere NSAIDS mwachangu, makamaka chifukwa zingakhale zophweka kugwiritsa ntchito mankhwala osokoneza bongo omwe amachititsa kupweteka ndi malungo kuchokera ku chimfine matenda.
Ntchito zina za NSAID zimaphatikizapo kupweteka kumutu, kupweteka kwa minofu, kupweteka kwa msambo komanso kuchepetsa mavuto ndi zowawa za tsiku ndi tsiku.
Anthu omwe ali ndi matenda opweteka kwambiri (IBD) amamva zowawa ndi ululu ngati wina aliyense. Ambiri amamva ululu tsiku ndi tsiku chifukwa cha ziwalo za m'mimba monga matenda a nyamakazi kapena zowawa za mankhwala monga mankhwala opweteka. Komabe, ena a gastroenterologists amalimbikitsa kuti awo omwe ali ndi IBD akhale kutali ndi NSAIDs. Chifukwa: NSAIDs zikhoza kukhala ndi zotsatira zowawa pa matenda a Crohn ndi ulcerative colitis.
Momwe NSAIDs imagwirira ntchito
NSAID zimagwira ntchito poletsa mazyme awiri m'thupi: cyclooxygenase-1 (COX-1) ndi cyclooxygenase-2 (COX-2) . COX-1 imathandiza kwambiri m'thupi ndipo COX-2 imachita ntchito yotupa. Ntchito ya COX-1 ndiyo kuyendetsa zinthu zotchedwa prostaglandins zomwe zimateteza mimba ya m'mimba kuchokera ku zidulo zomwe zimathandiza kudyetsa chakudya.
The prostaglandins yopangidwa ndi COX-2 imayendera njira yotupa ndi kumva ululu.
Izi zikutanthawuza kuti pamene ma NSAID amachepetsanso kupweteka ndi ululu, amachititsanso kuti chitetezo cha thupi chiwonongeke. Izi zingayambitse mavuto ambiri kwa anthu omwe ali kale ndi kutupa, kapena angathe kutupa, m'magawo awo.
NSAIDs ndi Ulcers
Ngakhale anthu omwe alibe IBD, NSAID zingathandize zilonda m'mimba komanso gawo loyamba la matumbo aang'ono ( duodenum ). NSAID zingayambitse kutupa ndi kuwonjezereka magazi m'matumbo aang'ono. Akatswiri ena osakaniza amadandaula kuti NSAID zingachititse IBD kuchoka ku chikhululuko .
NSAIDs ndi IBD
Kafufuzidwe ngati ma NSAID amathandizira zizindikiro za IBD akutsutsana, ndikupanga kutsutsana pa ntchito yawo pakati pa gastroenterologists. Kwa kalasi ya mankhwala otchedwa COX-2 inhibitors, pakalipano palibe umboni wambiri mu zotsatira zake kwa anthu omwe ali ndi IBD. Kafukufuku wina amasonyeza kuti NSAIDs ingakhudze chiwerengero cha anthu omwe ali ndi IBD, koma n'zosatheka kudziwa yemwe adzakhudzidwe ndi yemwe alibe. Zatsimikiziridwa kuti kugwiritsa ntchito COX-2 inhibitor, osati mankhwala omwe ali COX-1 ndi COX-2 inhibitor, angagwiritsidwe ntchito mosamala mwa iwo omwe IBD ili mu chikhululuko.
Anthu omwe ali ndi IBD ayenera kuonana ndi gastroenterologist awo asanatenge NSAID, ngakhale zomwe zilipo pa pepala. Ndichofunikira kwambiri kuti apange mamembala onse a gulu lachipatala kuti adziŵe zotsatira za NSAID zomwe angathe kukhala nazo pa IBD yawo.
Zomwe Anthu Omwe Angakhale Nawo Angathe Kuchita
Anthu omwe ali ndi IBD omwe akufunafuna kupweteka kwamtundu wambiri angakonde kuganizira acetaminophen.
Acetaminophen, yogulitsidwa pansi pa mayina ambiri, kuphatikizapo Tylenol, si NSAID ndipo ikhoza kukhala yabwino kwa anthu omwe ali ndi IBD amene akusowa kupweteka. Momwe acetaminophen amagwirira ntchito kuti achepetse ululu sizimveka bwino, koma akuganiza kuti zikuphatikizapo kuletsa kulengedwa kwa prostaglandins.
Nthawi zonse funsani kuwonjezera kwa mankhwala atsopano, makamaka omwe amagwiritsidwa ntchito kuthetsa ululu. Osati katswiri aliyense wa zaumoyo akudziwa kugwirizana kotheka pakati pa paillillers ndi IBD. Pamene anthu omwe ali ndi IBD adzachita opaleshoni kapena ndondomeko, ndizofunika kutsegula mchidziwitso cha mimba kuti mukambirane za mpumulo kuti mutsimikizire kuti muli ndi zatsopano zokhudza NSAID komanso momwe akugwiritsirani ntchito.
Pansipa pali tebulo la NSAID zomwe zimapezeka ndi mankhwala kapena pa pepala. Izi sizikutanthauza mndandanda wamakono, choncho chonde funsani kwa katswiri wamalonda kapena dokotala chifukwa cha nkhawa za mankhwala enaake.
Mankhwala Osagwiritsa Ntchito Steroidal Anti-Inflammatory (NSAIDs)
| Dzina lajambula | Dzina lachibadwa |
| Advil, Excedrin IB, Genpril, Haltran, Ibuprin, Ibuprohm, Ibu-Tab, Midrin 200, Medipren, Midbu IB, Motrin, Nuprin, Pamprin-IB, Rufen, Trendar | Ibuprofen |
| Aleve, Anaprox, Naprosyn | Naproxen Sodium |
| Amigesic, Anaflex 750, Marthritic, Mono-Gesic, Salflex, Salsitab, Disalcid | Salsalate |
| Anacin, Bayer, Bufferin, Ecotrin | Choline salicylate |
| Chotsani, Froben | Flurbiprofen Mlanduwo |
| Apo-Keto, Orudis, Oruvail, Rhodis | Ketoprofen |
| Apo-Sulin, Clinoril, Novo-Sundac | Sulindac |
| Aspergum, Bayer Bay, Bayer Childrens, Bufferin, Easprin, Ecotrin, Empirin, Genprin, Halfprin, Magnaprin, ZORprin | Aspirin |
| Butazolidin | Phenylbutazone |
| Cataflam, Voltaren | Diclofenac Yogwirizana |
| DayPro | Oxaprozin |
| Dolobid | Diflunisal |
| Feldene, Novo-Pirocam, Nu-Pirox | Piroxicam |
| Indocin SR, Indocid, Novo-Methacin | Indomethacin |
| Lodine | Etodolac |
| Meclomen | Meclofenamate Sodium |
| Mobic | Meloxicam |
| Nalfon | Fenoprofen Calcium |
| Ponstan, Ponstel | Meclofenamic acid |
| Relafen | Nabumetone |
| Tolectin | Tolmetin Sodium |
Zotsatira:
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