Zinthu Ziwiri Zimene Zimapangitsa Kukula Mwamsanga
Si zachilendo kuona zaka zing'onozing'ono kapena zazing'ono kuposa momwe mulili. Koma, taganizirani kuyang'ana makumi ambiri oposa zaka zanu. Kwa anthu okhala ndi progeria, chibadwa chomwe chimayambitsa ukalamba msanga, zimakhala zachilendo kuyang'ana zaka makumi atatu kapena kuposerapo kuposa momwe iwo aliri.
Ngakhale kupita patsogolo kumagwirizanitsa ndi Hutchinson-Gilford progeria, mawuwo angatanthauzenso Werner syndrome, omwe amadziwikanso ngati munthu wamkulu.
Hutchinson-Gilford Progeria
Hutchinson-Gilford progeria ndi yodabwitsa kwambiri, yokhudza ana 1 mpaka 4 miliyoni 8. Ana omwe ali ndi progeria amakhala ndi mawonekedwe abwino pamene abadwa. Zizindikiro za vutoli zimayamba kusonyeza nthawi iliyonse isanafike zaka ziwiri pamene mwanayo amalephera kulemera ndi kusintha kwa khungu. Popita nthawi. mwanayo akuyamba kufanana ndi munthu wachikulire. Izi ziphatikizapo:
- Kutaya tsitsi ndi tsitsi
- Mitsempha yabwino
- Maso otetezera
- Tsaya laling'ono
- Kupanga mawonekedwe a dzino
- Mphuno yophimba
- Miyendo yopweteka ndi ziwalo zomveka
- Mfupi yochepa
- Kutaya mafuta
- Kuchuluka kwa mafupa ( osteoporosis )
- Umodzi wolimba
- Hip kusokoneza
- Matenda a mtima ndi atherosclerosis
Pafupifupi 97 peresenti ya ana omwe ali ndi chiwerengero chapita patsogolo ndi Caucasus. Komabe, ana omwe akukhudzidwa amawoneka mofanana kwambiri ngakhale amitundu yosiyanasiyana. Ana ambiri omwe ali ndi zaka zambiri amakhala ndi zaka pafupifupi 14 ndipo amafa ndi matenda a mtima.
Werner Syndrome
Matenda a Werner amapezeka pafupifupi 1 pa 20 miliyoni.
Zizindikiro za Werner matenda - monga mafupipafupi kapena makhalidwe osagwirizana ndi kugonana - angapereke panthaŵi ya ubwana kapena unyamata. Komabe, zizindikiro zimakhala zowonekeratu kamodzi pamene munthu akugunda pakati pa 30s. Zizindikiro zingakhalepo:
- Kusinthanitsa ndi kugwedeza nkhope
- Kutsika kwa misala
- Khungu lenileni ndi kutayika kwa mafuta pansi pa khungu
- Kumeta tsitsi ndi tsitsi
- Mawu omveka kwambiri
- Zovuta za mano
- Maganizo ochepetsedwa
Matenda a Werner amapezeka kawirikawiri mwa anthu a Chijapani ndi a Sardinia. Anthu omwe ali ndi matenda a Werner amakhala ndi moyo wa zaka zoposa 46, omwe ali ndi matenda a mtima kapena khansa.
Kafukufuku Wotsatira
Matenda a Werner amayamba chifukwa cha kusintha kwa maselo a mtundu wa WRN pa chromosome 8. Progeria yomwe imayambitsa kusintha kwa jini la LMNA pa chromosome 1. Lamulo la LMNA limapanga mapuloteni a Lamin, omwe amachititsa khungu la maselo athu pamodzi. Ochita kafukufuku amakhulupirira kuti maselo osakhazikika ameneŵa amachititsa kuti munthu azikalamba mofulumira. Ochita kafukufuku akuyembekeza pakuphunzira ma jini amenewa omwe angapangitse chithandizo cha matenda onsewa komanso matenda omwe amatha kukhala oopsa kwa anthu omwe ali ndi mitundu yoyamba - monga atherosclerosis ndi matenda ena okhudzana ndi ukalamba.
> Zotsatira:
Kaiser, HW, (2002). Hutchinson-Gilford progeria. eMedicine, imapezeka pa http://www.emedicine.com/derm/topic731.htm
Progeria Research Foundation.
Scientific American.com. (1999). Kodi tikudziwa chiyani chifukwa cha Werner syndrome ndi progeria, matenda omwe amachititsa kuti ana asakalamba msanga?
Wozniacka, A. (2002). Progeria (Werner syndrome). eMedicine