Ndizowongolera, choncho sungani malingaliro awa
Glucosamine ndi zakudya zowonjezera nthawi zina zimathandiza kuchepetsa ululu wa bondo wamagazi (OA). Nthawi ina yotchuka, ntchito yake tsopano ikuchepa, makamaka chifukwa cha zotsatira zosiyana zowonjezera phindu lenileni la wothandizira.
Ngati mutenga glucosamine kapena mukuganiza za mayesero owonjezera (pansi pa chisamaliro cha dokotala wanu, ndithudi) apa pali zilembo zisanu zoti muzikumbukira:
Tidbit # 1: Glucosamine Kawirikawiri Amapezeka M'tcheru
Glucosamine ndi mankhwala achilengedwe (otchedwa shuga ya amino) yomwe imapezeka m'thupi labwino lopangidwa ndi mchere komanso synovial zamadzimadzi , zomwe zimaphatikizapo ziwalo zanu. Mu mafupa a osteoarthritis, kanyumba kakang'ono kamene kali m'magulu mwanu kamasokonekera, kuchititsa kupweteka ndi kuuma. Ululu ukhoza kukhala wovuta kwambiri ngati karotika imakhala yayitali kwambiri moti mafupa amayamba kusakanizana.
Tidbit # 2: Glucosamine Siliyendetsedwa Ngati Mankhwala
Ku United States, glucosamine amagulitsidwa ngati chakudya chowonjezera. Izi zikutanthauza kuti zimayang'aniridwa ndi United States Chakudya ndi Drug Administration (FDA) monga chakudya, mosiyana ndi mankhwala kapena mankhwala osokoneza bongo.
Ndicho, ngakhale kuti glucosamine ndi gawo lachilengedwe la karotila, sizikutanthauza kuti kutenga kuli kotetezeka bwino. Ndipotu, glucosamine ikhoza kusandutsa shuga wa magazi ndipo ingagwirizane ndi mankhwala ena monga Coumadin (warfarin) omwe ndi owopsa kwambiri.
Monga nthawizonse, onetsetsani kuti mutenge mankhwala, kuphatikizapo zowonjezeretsa, pansi pa chisamaliro cha dokotala wanu.
Tidbit # 3: Glucosamine Sungakhale Yothandiza pa Knee Osteoarthritis Yanu
Ngakhale kuti kafukufuku wofufuza za maselo a khunyu amapeza kuti glucosamine ikhoza kuyambitsa regrowth ya kanyumba ndi kupondereza njira zotupa zomwe zimayambitsa kuwonongeka kwa karoti, data ya labotaleyi siinatanthauzire ku chipatala.
Kuphunzira kwakukulu koyamba ku United States komwe kunayesa zotsatira zafupipafupi za glucosamine (pa knee osteoarthritis) idatchedwa kuyesa GAIT (Glucosamine Arthritis Intervention Trial).
Mu GAIT, anthu opitirira 1500 omwe ali ndi mafupa a m'magazi amapatsidwa mwachangu ku umodzi mwa magulu asanu achipatala:
- Glucosamine pa 500mg katatu pa tsiku (okwana 1500mg pa tsiku)
- Chondroitin sulphate (komanso zakudya zowonjezera ndi zakuthupi za cartilage) pa 400mg katatu patsiku (1200mg pa tsiku)
- Glucosamine ndi chondroitin sulfate pamodzi
- Celecoxib (antisteroidal anti-inflammatory, kapena NSAID) pa 200mg tsiku ndi tsiku
- Malo a placebo (chinthu chosagwira ntchito)
Zotsatira za phunziro la GAIT zinasonyeza kuti ophunzira omwe akugwira NSAID celecoxib adamva kupweteka kwapadera kwapakati pa placebo.
Panalibe kusiyana kwakukulu pakati pa mankhwala ena omwe anayesedwa ndi placebo.
Ngakhale, m'maphunziro ena omwe ali ndi vuto lopweteka kwambiri, glucosamine pamodzi ndi chondroitin sulphate amapereka mpumulo waukulu poyerekeza ndi placebo. Ochita kafukufukuwo, adati, chifukwa kukula kwa gawoli kunali kochepa kwambiri, kufufuza uku kuyenera kuonedwa ngati koyambirira ndipo kuyenera kuwonetsedweratu mu kafukufuku wamtsogolo.
Odwala omwe amamva kupweteka kwa bondo (mosiyana ndi zovuta kapena zovuta) glucosamine ndi chondroitin sulfate palimodzi kapena okha sizinapereke chithandizo chachikulu cha kupweteka.
Tidbit # 4: Pali mitundu iwiri ya Glucosamine
Ndikofunika kudziwa kuti glucosamine imaperekedwa ndi mitundu iwiri ya mchere, hydrochloride kapena sulphate. Phunziro la GAIT (tatchulidwa pamwamba) linagwiritsidwa ntchito glucosamine hydrochloride. N'zochititsa chidwi kuti kafukufuku amene wasonyeza, ngakhale ang'onoang'ono, amagwiritsidwa ntchito glucosamine sulfate pofuna kuchiza osteoarthritis m'malo mwa glucosamine hydrochloride.
Mwachitsanzo, phunziro lalikulu ku International Journal of Clinical Practice linalongosola odwala oposa 3000 ali ndi mafupa a m'magazi m'mayesero 19 osiyanasiyana.
Olemba phunziroli anatsimikizira kuti glucosamine hydrochloride siidapindulitsa kuthetsa ululu (monga kuyesedwa kwa GAIT).
Komabe, mlingo waukulu wa glucosamine sulphate (1500mg pa tsiku) ukhoza kukhala ndi zotsatira zothandizira pamene watengedwa kwa miyezi yoposa 6. Zomwe zimagwira ntchito zimatanthauza kuti glucosamine sulphate ikhoza kuthetsa luso la munthu kugwiritsa ntchito bondo (kapena mawondo) ndi osteoarthritis.
Tidbit # 5: Zimene American College of Rheumatology States Zokhudza Glucosamine
Malingana ndi American College of Rheumatology, kapena ACR, anthu omwe ali ndi mafupa a m'magazi sayenera kugwiritsa ntchito glucosamine. Komabe, malangizowo adapangidwira "kukhala oyenera," monga momwe ACR ikudziwira kuti kugwiritsa ntchito glucosamine kumatsutsanabe.
M'malo mwake, ACR imalimbikitsa zotsatirazi zothandizira maondo OA:
- Tylenol (acetaminophen)
- NSAIDs (kaya ndi pakamwa kapena pakhungu lanu)
- Ultram (Tramadol)
- Majekeseni a corticosteroid mu malo olowa
Mawu Ochokera
Pamene lonjezo la glucosamine ngati njira yothandizira bondo la mitsempha la knee silinatuluke ndendende, anthu ena adzalitenga ilo ndikupeza kuti likugwira ntchito kwa iwo.
Pamapeto pake, mosasamala za dongosolo lanu lachidziwitso la mankhwala a knee, ndifunika kuti muwone dokotala wanu kuti azitsatira nthawi zonse. Mwanjira imeneyi mungasinthe mankhwala anu monga momwe thanzi lanu limagwirira ntchito ndikufufuza kumaonekera.
> Zotsatira:
> Hochberg MC et al. American College of Rheumatology 2012 akulimbikitsanso kugwiritsa ntchito mankhwala osagwiritsiridwa ntchito ospharmacologic ndi mankhwala okhudza mankhwala opatsirana m'magazi a dzanja, chiuno, ndi bondo. Mankhwala Osamalira Amagazi (Hoboken) . 2012 Apr; 64 (4): 465-74.
> Jerosch J. Zotsatira za glucosamine ndi chrondroitin sulphate pamatenda a m'magazi ku OA: Momwe mumaonera othandizira ena omega-3 fatty acids. Int J Rheumatol . 2011; 2011: 969012.
> Padziko Lonse la Zowonjezera ndi Zogwirizanitsa Zaumoyo. (2014). Glucosamine ndi Chondroitin kwa Osteoarthritis.
> Wu D, Huang Y, Gu Y, Fan W. Njira zabwino zokonzekera za glucosamine pofuna kuchiza osteoarthritis: meta-kufufuza mayesero osadziwika bwino, aŵiri osawona, omwe amayang'aniridwa ndi placebo. Int J Clin Pract. 2014 Jun; 67 (6): 585-94.