Iron Overload ndi chiyani?

Kuika magazi ambiri ndizofunikira kwa odwala ena a khansa ya m'magazi, a lymphoma ndi a myeloma. Kuwotcha kumagwiritsidwa ntchito poonjezera kuwerengera kwa maselo a magazi ndi kuchiza zizindikiro za kuchepa kwa magazi monga kutopa, kuganiza molakwika, kupuma pang'ono ndi kufooka . Komabe, kuika magazi ambiri m'kupita kwa nthawi kungachititse kuti chitsulo chiziwongolera - chomwe chingawononge mtima ndi chiwindi, ngati sichikutsatiridwa.

Mmene Zimakhalira

Iron imathandiza kwambiri mthupi lathu. Zimathandizira pazinthu zambiri za chilengedwe, kuphatikizapo kufanana kwa DNA pamene maselo akugawanitsa, ndi kutulutsa mpweya kuchokera m'mapapo kupita ku maselo ndi matenda athu. Chitsulo chimene timalowetsa kudzera mu chakudya chathu chimamangiriza puloteni yotchedwa transfrin ndipo imazungulira m'magazi athu a m'magazi.

Kawirikawiri, chitsulochi chimagwiritsidwa ntchito popanga hemoglobin, chinthu chokhala ndi maselo ofiira ofiira omwe amanyamula mpweya umene timapuma m'matumba athu . Dothi lachitsulo likusungidwa m'chiwindi, kuti ligwiritsidwe ntchito mtsogolo.

Thupi la munthu silingakwanitse kuchotsa kapena kuchotsa zitsulo zochulukirapo, ngakhale kuti chitsulo chimatayika mu njira zowononga monga kukhetsa maselo a khungu. Pomwe thupi lapamwamba lachitsulo likasungidwa, chitsulo chimayamba kumangika m'madera ena a thupi, zomwe zimapangitsa kuti chitsulo chikhale cholemera.

Magazi ofiira magazi amagawira kuchuluka kwa chitsulo.

Kwa anthu abwinobwino, pafupifupi 1-2 mg yachitsulo amatembenuzidwa mu tsiku lopatsidwa - kutanthauza chitsulo chomwe chatengedwa kuchokera ku zakudya ndi kutaya mwa kukhetsa maselo a khungu ndi maselo a m'mimba, mwachitsanzo. Selo limodzi la maselo ofiira a magazi ofiira (PRBCs), komabe liri ndi pafupifupi 200-250mg . Kawirikawiri, odwala amalandira mayunitsi awiri nthawi iliyonse akamapatsidwa magazi, kotero ndizowonjezera 500 mg tsiku limodzi.

Zotsatira

Ngati chitsulo chakudetsa mphamvu ya thupi kuti iisunge bwino, ikhoza kuvulaza m'njira zingapo. Choyamba, pamene pali chitsulo china m'thupi kusiyana ndi transfrinti kuti chigwirizane nacho, chimayenda pandekha ngati chitsulo chosagwiritsidwa ntchito (NTBI). Fomu iyi yachitsulo ndi poizoni kwa matupi athu, ndipo imayambitsa kuwonongeka kwa ziwalo zathu ndi ziwalo pamtunda.

Kuonjezera apo, chitsulo chochulukira chimakula m'mtima, m'mapapo, m'maganizo, m'matenda a endocrine, chiwindi komanso mafupa.

Osanenedwa, kusonkhanitsa uku kungayambitse:

• Kutaya mtima

• Kupanda mphamvu

• Shuga

• Kuchulukanso kwa chiwindi

• Matenda a nyamakazi

• Hypothyroidism (chithokomiro chopanda mphamvu)

• Kukula mwakuya

• Erectile kulephera

• Khansara

• Kusokonezeka maganizo

Umboni wina umasonyezanso kuti kachilombo ka bakiteriya kamakhala chimodzi mwa zotsatira za kulemera kwa chitsulo.

Ndani Ali Pangozi?

Anthu omwe ali pachiopsezo cha kuika magazi m'thupi mwachitsulo ndi omwe adalandira kuikidwa magazi kwa maselo ofiira ofiira. Akuluakulu omwe amalandira magazi nthawi zonse amapezeka pangozi patatha pafupifupi 20 ma unit unit of PRBCs, kapena kuikidwa magazi 10 ngati mutapeza awiri awiri pa nthawi.

Odwala omwe ali ndi khansa ya magazi ndi mafuta a m'mawere, monga khansa ya m'magazi ndi maimymphoma, amafunika kuika magazi ambiri pambuyo pa mankhwala a chemotherapy.

Odwala omwe ali ndi myelodysplastic syndromes (MDS) nthawi zambiri amakhala ndi hemoglobini yotsika mtengo ndipo ambiri amadalira kuika magazi, kuwaika pangozi yaikulu yachitsulo. MDS ndi kuchepa kwa magazi m'thupi kungapangitsenso odwala kuti azidya zitsulo zochulukirapo, ndikupangitsa vutoli kukhala loipitsitsa.

Kudziwa

Nthawi yowonjezera imatha nthawi, ndipo nthawi zambiri odwala sangasonyeze zizindikiro. N'zosakayikitsa kuti zowonjezera zitsulo zidzapezeka ndi zotsatira za labotale munthu asanakhale ndi zizindikiro.

Kafukufuku wochulukirapo kuti ayang'ane kutentha kwachitsulo amatchedwa serum ferritin. Awa ndi mayeso a magazi omwe angachitidwe nthawi zonse kwa anthu omwe ali pangozi.

Serum ferritin amawonjezeka pamene kuchuluka kwa NTBI kumawonjezeka m'magazi. Madzi a ferritin omwe amaposa 1,000 mcg / L amasonyeza kuti chitsulo chimagwedezeka. Amuna odwala nthawi zambiri amakhala ndi serrit ferritin ya 24-336 mcg / L ndi akazi abwino 12-307 mcg / L. Matenda ndi zizindikiro zina zingachititse kuti ferritin yambiri ikamasulidwe, komabe, zomwe zingapangitse kuwerenga kosawerengeka kosakhulupirika, kotero kuti kuyesa nthawi zonse ndilozolowereka.

Madokotala angasankhenso kuchita chiwindi cha chiwindi kuti ayang'ane ndondomeko ya chitsulo. Pamene mayesowa angapereke zotsatira zowonjezereka kusiyana ndi maseŵera a serum ferritin, amafunika njira yowonongeka yomwe ingabweretse mavuto, monga matenda ndi magazi. Zotsatira za chiwopsezo zoposa 7 mg chitsulo pa gramu ya chiwindi zimasonyeza kuti chitsulo chimagwedezeka.

Maphunziro a kufotokozera angasonyezenso zotsatira zomwe zikuwonetseratu kuti chitsulo chimagwedezeka. Kujambula kwa maginito (MRI) kungagwiritsidwe ntchito pozindikira kuti chitsulo chimagwira pachiwindi ndi mtima. MRI ikhoza kugwiritsidwa ntchito limodzi ndi chiwindi cha chiwindi kuti muzindikire kuti chitsulo chimadzaza kapena chokha. Komabe, kusungidwa kwa chitsulo sikungotsimikizidwe kuti ndi MRI nthawi zina, ngati nthawi yachitsulo imapezeka pamatenda.

Chithandizo

Pali njira zikuluzikulu ziwiri zomwe chitsulo chimagwiritsidwa ntchito: chithandizo cha phlebotomy ndi iron chelation mankhwala.

Mankhwala a phlebotomy ndi njira yofulumira kwambiri komanso yothandiza kwambiri yopezera mchere pansi pa wodwalayo. Tsoka ilo, silingagwiritsidwe ntchito pa odwala omwe amakhalabe ochepa. Choncho, nthawi zambiri amasungidwa kwa odwala omwe ali ndi khansa ya m'magazi kapena lymphoma akukhululukidwa.

Pa chithandizo cha phlebotomy, namwino kapena dokotala adzalowetsa singano yaikulu m'mitsempha yanu , kawirikawiri mdzanja lanu. Adzachotsa pafupifupi 500 ml magazi m'mthupi mwako pafupi mphindi 15-30. Ngati munaperekapo magazi, mumapeza lingaliro. Magazi amenewa ali ndi 250 mg yachitsulo. Pamene chitsulocho chichotsedwa m'magazi anu, chiwindi chanu chimatulutsa zosungiramo zake ndipo pamapeto pake kuchuluka kwa chitsulo kungabweretsedwe kumtundu woyenera. Phlebotomy ikhoza kuchitidwa kamodzi kapena kawiri pa sabata kuti pakufikira cholinga cha serum ferritin ma 50-100mcg / L.

Chithandizo cha Iron Chelation chimagwiritsa ntchito mankhwala omwe amamanga, kapena chelate, chitsulo ndikuthandizira kuchotsa mthupi. Cholinga cha mankhwalawa ndi kuchotsa zitsulo zochuluka kuchokera ku magazi ndi ziwalo za thupi. Ngakhale mankhwalawa amagwira bwino ntchito yachitsulo cha plasma ndi chiwindi, sizothandiza pakuchotsa zitsulo kuchokera mu mtima.

Deferoxamine (Desferal), deferasirox (Exjade), ndi deferiprone (Ferriprox) ndi mankhwala atatu oterewa.

Mankhwala a chelator amathandiza kwambiri kuchepetsa chiwerengero cha NTBI, koma masitepewa amakula mwamsanga ngati mankhwala atha. Choncho, mankhwalawa ayenera kutengedwa ndendende monga momwe akufunira kuti agwire bwino ntchito. Izi zingakhale kudzipereka kwakukulu kwa odwala ena. Ofufuza a Iron salinso opanda zotsatira, ndipo ngozi ndi phindu lachitsulo chachitsulo chiyenera kulemedwa mosamala.

Kuphatikiza pa mankhwala awa, wothandizira zaumoyo wanu angapange malangizowo kuti achepetse kuchuluka kwa chitsulo chomwe iwe umatengera kupyolera mu chakudya chako. Ngakhale izi ndizomwe zimakhala zomveka mwachidwi, ndi zochepa zochepa, phindu lachitsulo mu zakudya ndilokayikitsa chifukwa njirayi imakhala ndi chozizwitsa cha "chotsitsa mu chidebe," komanso popeza chithandizo chachitsulo monga phlebotomy chiri kutali zothandiza kwambiri kuchepetsa zitsulo.

Malangizo Odzikonda

Kuikidwa magazi nthawi zambiri ndi kofunikira komanso kothandiza kwambiri pa khansa ya khansa ya m'magazi komanso ya lymphoma. Kuchepa kwa magazi kungawonongeke, ngakhale kupha, zotsatira za thupi lanu ndi kuikidwa magazi sikutheka.

Komabe, pali zinthu zomwe mungachite kuti zitsulo zanu ziziyang'aniridwa bwino. Onetsetsani kuti gulu lanu laling'onoting'ono la zamankhwala likudziŵa zonse za mbiri yakale yoika magazi. Mwinamwake mwalandira zaka PRBCs zapitazo kuti mukhale osagwirizana, koma dokotala wanu ayenera kudziwa za izo tsopano. Kumbukirani kuti chitsulo sichitha kutulutsidwa kuchokera mthupi lanu, kotero kuikidwa magazi komwe mumalandira m'moyo wanu kuli ndi mphamvu yowonjezera chitsulo lero.

Muyeneranso kuyesa kufufuza kuikidwa magazi komwe mumalandira. Izi sizingakhale zophweka, ndipo pakhoza kukhala nthawi zina mu mankhwala anu pamene zikuwoneka ngati zonse zomwe mukuchita ndikutengedwera, koma zidzakhala zofunikira mtsogolo.

Gulu lanu la thanzi labwino liyenera kuyamba kuyang'anitsitsa miyeso yanu ya serum ferritin mukalandirapo pafupifupi magawo 20 a magazi. Ngati mumakhala ndi mawiri awiri panthawi, izi zimangokhala kuikidwa magazi. Ngati sazilangiza, muyenera kuzipempha.

Pansi

Odwala amene amalandira magazi ambiri m'moyo wawo ali pa chiopsezo chotengeka ndi chitsulo. Chifukwa cha matenda awo, komanso mankhwala ochizira, odwala matenda a khansa ndi amagazi nthawi zambiri amadalira kuikidwa magazi. Ngati simunasankhidwe, kukhuta kwachitsulo kungayambitse kuwonongeka kwa thupi komanso ngakhale imfa, koma mankhwala othandiza alipo.

Ngakhale kuti sikutheka kupeŵa kuikidwa magazi, odwala angathandize kudziteteza okha pokhala akumbukira chiwerengero cha mayunitsi omwe akulandira ndikupempha kuchipatala kuyesa kuyesera kuperewera.

Kusinthidwa kwa March 2016, TI.

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