Matenda amodzi omwe amapezeka ndi mapuloletti a magazi ambiri
Chofunika kwambiri cha thrombocythemia (ET) ndi matenda osadziwika omwe mafupa amapanga mapaleti ambiri. ET ndi mbali ya matenda omwe amadziwika kuti matenda a myeloproliferative, gulu la matenda omwe amadziwika ndi kuwonjezeka kwa mtundu wina wa magazi.
Mipata ya maselo ndi maselo omwe amachititsa kuti magazi asamangidwe.
Kwa anthu omwe ali ndi ET, kukhalapo kwa mapuloteni ochulukirapo kungakhale kovuta, kuchititsa kupangika kosayenera kwa magazi mkati mwa chotengera cha magazi (mkhalidwe wotchedwa thrombosis ).
Ngakhale kuti chifukwa chenicheni cha ET sichidziwika, pafupifupi 40 mpaka 50 peresenti ya anthu omwe ali ndi matendawa ali ndi kusintha kwa chibadwa komwe kumatchedwa JAK2 kinase. ET ndi matenda osadziwika kwambiri, omwe amakhudza anthu osachepera atatu mwa 100,000 pa chaka. Zimakhudza amai ndi abambo amitundu yonse koma zimawonekera makamaka kwa akuluakulu oposa 60.
Zizindikiro za Zofunika Kwambiri Thrombocythemia
Anthu omwe ali ndi thrombocythemia yofunikira nthawi zambiri amapezeka atatha kukhala ndi zizindikiro zina zokhudzana ndi magazi . Malinga ndi kumene kachokera, zizindikiro zingakhalepo:
- Mutu
- Chizungulire kapena kumutu
- Kufooka
- Kutaya
- Misozi yamphongo
- Kusintha kwa masomphenya kumasintha
- Kunjenjemera, kufiira, kumangirira, kapena kutentha kwa manja ndi mapazi
Nthawi zambiri, kutuluka kwachilendo kosazolowereka kungapangidwe chifukwa cha ET.
Ngakhale kuchuluka kwa mapuloteni otsika kungayambitse magazi chifukwa chosowa kofiira, mapuloletsiti owonjezera amakhala ndi zotsatira zofanana ndi zomwe mapuloteni amafunika kuziphatika (wotchedwa von Willebrand factor) akhoza kufalikira kwambiri kuti azigwira ntchito. Izi zikachitika, kuvulaza kosazolowereka, nosebleeds, kutuluka m'mphuno kapena chifuwa, kapena magazi m'mphepete mwazi .
Kupanga magazi nthawi zina kungakhale koopsa ndipo kungayambitse matenda a mtima, kupwetekedwa, kusokonezeka kwa ischemic ("mini-stroke"). Mphungu yowonjezereka ikuwonekeranso pozungulira 20 peresenti ya milandu chifukwa cha kulepheretsedwa kwa magazi.
Kuzindikira Kufunika Kwambiri Kwambiri
Chofunika kwambiri kuti thrombocythemia iyambe kuwonedwa panthawi yoyezetsa magazi nthawi zonse anthu omwe alibe zizindikiro kapena zizindikiro zosadziwika bwino (monga kutopa kapena kupweteka mutu). Magazi aliwonse a mapiritsi oposa 450,000 pa microliter amawerengedwa ngati mbendera yofiira. Anthu oposa milioni pa microliter aliwonse ali ndi chiopsezo chachikulu cha kuvulaza kapena kupuma kwachilendo.
Kuyeza kwa thupi kungasonyeze kutambasula kwa mphutsi komwe kumapwetekedwa ndi kupweteka kapena kukwanira kumimba kumanzere komwe kumatha kufalikira kumapazi kumanzere. Kuyesedwa kwa majeremusi kungathenso kutengedwera kuti muzindikire kusintha kwa JAK2.
Kudziwa kwa ET ndiko makamaka kusaganizira, kutanthauza kuti chifukwa china chilichonse chokhala ndi chiwerengero cha mapepala apamwamba chiyenera kukhala choyamba kuti asatuluke. Zina zomwe zimagwirizanitsidwa ndi mapiritsi apamwamba amaphatikizapo polycythemia vera , matenda aakulu a myeloid , ndi myelofibrosis .
Kuchiza Kufunikira Kwambiri Thrombocythemia
Chithandizo cha matenda opatsirana kwambiri chimadalira momwe kuwerengera kwa platelet kukwera komanso kuthekera kwa mavuto.
Sikuti anthu onse okhala ndi ET amafuna chithandizo. Ena amangoyang'anitsitsa kuti awone kuti vutoli silikuipiraipira.
Ngati nkofunika, chithandizochi chikhoza kukhala aspirin tsiku ndi tsiku kwa omwe amawoneka kuti ali pangozi yochepa. Kwa iwo omwe ali pachiopsezo chachikulu (chifukwa cha ukalamba, mbiri yachipatala, kapena zochitika za moyo monga kusuta kapena kunenepa kwambiri) angapindule ndi mankhwala monga hydroxyurea, anagrelide, kapena alpha interferon, zonse zomwe zimatha kuchepetsa nambala ya platelet.
Muzidzidzidzi, plateletpheresis (njira yomwe magazi amagawanika m'zigawo zake) zingathe kupangidwira kuti pang'onopang'ono kuchepetsa chiwerengero cha platelet.
> Chitsime:
> Bleeker, J. ndi Hogan, W. "Thrombocytosis: Kufufuza Kufufuza, Kusokonezeka kwa Thrombotic Risati Stratification, ndi Njira Zowonongeka Zowopsa." Thrombosis. 2011; Nkhani ID 536062.