Aliyense wogwiritsa ntchito mankhwala osokoneza bongo amakhala ndi njira yapadera yogwiritsira ntchito mankhwala
Pakalipano, mankhwala okhawo omwe alipo alipowa ndi zakudya zopanda thanzi . Koma izi zikhoza kusintha posachedwa.
Ambiri opanga mankhwala pakalipano akuyesa mayesero a kachipatala kuti aone kuti chitetezo ndi zothandiza za olemba mankhwala amodzi. Aliyense ali ndi njira yosiyana ndi njira (MOA). Tikuyembekeza kuti poletsa njira yothetsera matendawa, tsiku limodzi tidzatha kuthetsa matenda a leliac kuchokera ku lexicon yodwala matenda .
Pakati pa anthu atatu omwe akudalira kwambiri mankhwalawa:
INN-202 (Larazotide Acetate)
Kupanga Pharmaceutical's INN-202 (larazotide acetate) ndi mankhwala omwe amagwiritsira ntchito mphamvu yowonjezera yogaya zakudya yomwe imawoneka kuti ikhoza kuthetsa gluten musanayambe chitetezo cha mthupi. Zotsatira za chiyeso chachiwiri chakumayambiriro kwachiwiri zinalonjeza ndikuwonetsa kuti mankhwalawa anali otetezeka komanso olekerera. Mankhwalawa a MOA onse amachepetsa kuperewera kwamatumbo pamene akuyendetsa kayendetsedwe ka ma antigen m'mimba.
Ngakhale kuti INN-202 ingachepetse kwambiri zizindikiro za matenda a leliac , sikungatheke kuti munthu adye zakudya zopanda malire za gluten. Zakudya zina zodyera zidzafunikabe.
Dongosolo la US Food and Drug Administration (FDA) lafufuza mofulumira mankhwalawa. Mayesero amachilombo a Phase III ali panopa. Zotsatira za mayesero zingakhalepo nthawi zina mpaka kumapeto kwa 2018
Katemera wa Nexvax2
Nexvax2 ndi wokhayokha yemwe akufuna kuti adziletse anthu omwe alimbana ndi matendawa ndi kuwathandiza kuti abwerere ku chakudya choyenera. Nexvan2 yatsiriza kale chiyeso cha chitetezo cha Phase Ib ndipo akuyenderera ku mayesero akuluakulu a Phase II.
Nexvax2 imayikidwa pa katemera wothandizira odwala omwe akuwongolera anthu omwe ali ndi matenda.
Zimakhazikitsidwa pa mfundo zomwezo monga mankhwala achikhalidwe omwe amagwiritsidwa ntchito pa chifuwa. Zitsanzo zofanana ndi katemera zimayang'aniridwa kuti zithetse matenda omwe amabwera chifukwa cha matendawa, monga multiple sclerosis, mtundu wa shuga, ndi matenda a nyamakazi.
Nexvax2 ndi ma genetiki ofanana ndi anthu omwe ali ndi jini (DQ2) yeniyeni yomwe ilipo 90 peresenti ya anthu omwe ali ndi matendawa. Zoterezi, katemera sangagwire ntchito ngati mulibe DQ2,
Pambuyo pazimenezi, ofufuza a mafunso akuluakulu ali ndi zotsatira zotalika za katemera. Mlandu wa Phase Ib unkaphatikizapo dosing, Ngakhale kuti zotsatirazi zinali zowonjezera (anthu ambiri adatha kuthetsa vuto la gluten kusiyana ndi omwe ali pa placebo), zimakhala zikuwonekeratu kuti mankhwalawa ndi amphamvu komanso otalika bwanji.
Palibe mawu komabe pamene ochita kafukufuku adzayamba mayesero okhudzana ndi matenda a Phase II / III.
BL-7010
BL-7010 imapereka njira yosiyana kwambiri yochizira matenda a leliac. M'malo molimbana ndi matumbo kapena kuyankha kwake, BL-7010 imamangiriza puloteni ya gluten yokhayo ndipo imalepheretsa kukwanira.
BL-7010 ndi polima omwe sali othandizira omwe amatha kubisa gluteni kuchokera ku michere yomwe ikufuna kuidula. Mwa kukwaniritsa izi, chitetezo cha mthupi sichikhoza kuyambitsa yankho lokhalokha.
Mankhwala osokoneza bongo ndi mankhwala amatha kuthamangitsidwa m'thupi.
Pambuyo pa mayesero athunthu a Phase I ndi II, opangawo anatenga njira ina ndipo anayamba kulimbikitsa BL-7010 monga chowonjezera chakudya osati mankhwala osokoneza bongo. Mu January 2016, kampaniyo inalandira chivomerezo ichi kuchokera ku European Union ndipo panopa ikuyesa kulandira chithandizo chachipatala motsatira ndondomeko ya chipangizo chachiwiri Chachiwiri.
Mawu Ochokera
Pamene akulonjeza, sikudziwikiratu ngati mankhwala ena onsewa angapangitse malonda. Pamapeto pake, wofunsayo aliyense ayenera kukwaniritsa malonjezano atatu ngati akuyenera kuonedwa kuti ndi othandiza.
Zidzakhala zosavuta kuchitidwa, zowonjezereka, kupereka ndondomeko zoyenera zogwiritsira ntchito ndondomeko, zikhale zolekerera, ndipo, makamaka chofunika, zikhale zotsika mtengo.
Kotero pali zambiri zoti ziyankhidwe. Koma popitiriza kufufuza ndi kuzindikira zambiri za njira za matendawa , tikhoza kuona posachedwa tsiku limene sitikukhalabe ndi gluten.
> Chitsime:
> Wingjiranirun, M .; Kelly, C .; ndi Leffler, D. "Mkhalidwe Wino wa Matenda Omwe Amachiza Omwe Amagwiritsa Ntchito Mankhwala T." American Journal of Gastroenterology. 2016; 111 (6): 779-86.