Mavuto osiyanasiyana a khungu, kuphatikizapo eczema , urticaria ndi angioedemia, ndi erythema multiforme, akhoza kuvulaza nthawi yoyamba. Pamene izi zikuipiraipira masiku atatu kapena khumi isanayambe, mayiyo akhoza kukhala ndi progesterone dermatitis (APD). APD imatha kukwanitsa kupita ku anaphylaxis .
Mtundu wina wa anaphylaxis womwe umakhudzana ndi msambo ndi matenda a anaphylaxis. Izi zonse zikhulupiliridwa kuti ndizochepa.
Progesterone Dermatitis
Kupanga mavitamini a progesterone dermatitis (APD) kumachitika chifukwa cha zomwe zimachititsa kuti mayi asagwiritsidwe ntchito ndi progesterone ya mkazi . Zizindikiro zimachitika kulikonse masiku atatu kapena khumi isanayambike kuyamba kuyambira ndikuyamba kuthetsa masiku awiri kapena awiri mutangoyamba kumene kusamba. APD ikhoza kukhala ndi zizindikiro zosiyana, ngakhale zambiri, ngati siziri zonse, zimaphatikizapo ziphuphu za khungu. Izi zimaphatikizapo chizungu, ming'oma, kuphulika kwa mankhwala osokoneza bongo, erythema multiforme, angioedema, ndi ngakhale anaphylaxis. Zingakhale zosawonekera kwa amayi omwe athudzidwa kuti zizindikiro zake zikuipiraipira nthawi yoyamba, ndipo nthawi zambiri amatenga dokotala kuti afunse funso loipitsa zizindikiro zokhudzana ndi msambo.
APD ikhoza kuyambitsidwa ndi mayi yemwe akugwiritsa ntchito mapiritsi oletsa kubereka kapena mankhwala ena a hormone okhala ndi progesterone omwe amachititsa kuti adzidziwitse ku hormone. Mimba ingathenso kuyambitsa progesterone, ndipo mimba ikhoza kukhala ndi zotsatira zambiri pa chitetezo cha mthupi ndipo ingakhudze kwambiri zovuta zosiyanasiyana.
Azimayi ena angathe kukhala ndi APD chifukwa cha kuyanjana ndi corticosteroids , zomwe zimakhala ndi maselo ofanana ndi mahomoni. Ngakhale kusintha kwa majeremusi ena, monga estrogen, kumachitika, izi sizodziwika kwambiri kusiyana ndi momwe zimachitikira progesterone.
Kudziwa kwa APD kumafuna kuti ma antibodies a IgE amenyane ndi progesterone, omwe amachitidwa ndi kuyesera khungu . Kuyezetsa khungu ndi progesterone kungatheke ndi akatswiri ambiri, omwe angatsatidwe ndi vuto la mankhwala kudzera mu jekeseni wa progesterone ndi kuyang'anitsitsa kwa zizindikiro. Ndondomekoyi iyenera kuchitidwa ndi dokotala yemwe amadziwa kuti akudwala matenda odwala matenda a chifuwa chachikulu komanso matenda a anaphylaxis.
Chithandizo cha APD chikhoza kupindula ndi kugwiritsa ntchito antihistamines ndi mankhwala kapena jekeseni ya corticosteroids, ngakhale mankhwalawa angakhale othandiza kuchiza zizindikiro m'malo mokonza vutoli. Mankhwala omwe amachititsa kuti ovrolide asapitirire, monga leuprolide, amalepheretsa kukula kwa progesterone pa nthawi ya kusamba ndipo ndizoperekedwa kwa APD. Kawirikawiri, kuchotsa opaleshoni ya mazira ndi chiberekero kumafunika m'mavuto aakulu a APD pamene mankhwala sangathe kulamulira zizindikiro.
Matenda a Anaphylaxis
Matenda a chifuwa ndi matenda ena omwe amakhudzana ndi msambo. Azimayi omwe ali ndi vutoli amawona zizindikiro za anaphylaxis posachedwa kumayenda kumayambiriro ndipo zizindikiro zimapitirira mpaka mvula ikutha. Mosiyana ndi APD, komabe kudwala anaphylaxis si vuto koma kumayambitsa prostaglandins kuchokera ku chiberekero cha m'mimba (endometrium), chomwe chingapangidwe m'magazi. Matendawa amatengedwa pa chipatala, chifukwa kuyesa kwa progesterone (ndi mahomoni ena) ndi zoipa. Kuchiza kwa matenda a mwana wamwamuna wathanzi kumapindula ndi kugwiritsa ntchito mankhwala osagwiritsidwa ntchito poletsa anti-inflammatory (NSAIDs ) , monga Indocin (indomethacin).
Kuchotsa opaleshoni ya mazira ndi chiberekero kumafunika pa matenda aakulu ophera mwana pamene mankhwala sangathe kulamulira zizindikiro.
> Zotsatira:
> Progesterone Dermatitis. NIH Yachibadwa ndi Zachilombo Za Zachilombo Zachilombo. https://rarediseases.info.nih.gov/diseases/9139/autoimmune-progesterone-dermatitis.
> Bauer CS, Kampitak T, Messieh ML, Kelly KJ, Vadas P. Heterogeneity powonetsa ndi kuchiza matenda ophera mwana. Zambiri za zozizira, chifuwa chachikulu ndi chithumwa . 2013; 111 (2): 107-111. lembani: 10.1016 / j.anai.2013.06.001.
> Nguyen T, Ahmed AR. Sungani ma progesterone dermatitis: Kusintha ndi zidziwitso. Zomwe Zimapangidwira Zokha . 2016; 15 (2): 191-197. lembani: 10.1016 / j.autrev.2015.11.003.