Pamene Hypothalamus Yanu Simungathe Kugwira Ntchito Mwanzeru
Matenda a Kallmann amakhudza amuna nthawi zambiri kusiyana ndi amayi, omwe amachititsa pafupifupi 1 mwa amuna 8,000 mpaka 10,000 ndipo amodzi mwa amayi 40,000 mpaka 70,000 padziko lonse lapansi.
Matenda a Kallmann angalandire kapena akhoza kuchitika kwa wina yemwe alibe mbiri ya banja la matendawa. Fomu yowonongeka kwambiri ndi mawonekedwe ojambulidwa ndi X. Jini la KAL1 pa X chromosome liri ndi mawonekedwe a mawonekedwe awa.
Fomu yowonjezera yowonjezera yowonjezera imakhala chifukwa cha kusintha kwa jini la KAL2 pa chromosome 8. Icho cholandira mwa njira yoyendetsera autosomal . Maonekedwe achitatu a matenda a Kallmann amachokera ku kusintha kwa jini la KAL3 ndipo adzalandira ngati vuto lodzidzimutsa kwambiri la autosomal disorder. Malo enieni a jini la KAL3 anali asanapezeke.
Zizindikiro
Kallmann syndrome, mbali ya ubongo, hypothalamus, silingathe kugwira ntchito bwino. Izi zimayambitsa zizindikiro monga:
- kulephera kupyolera mu kutha msinkhu
- osamva kununkhira (anosmia) kapena mphamvu yofooka (hyposmia)
- mayeso osamvetseka (cryptorchidism) mwa amuna
- mbolo yaing'ono ( microphallus ) mwa amuna
- Kusamba sikuyamba pakati pa amayi (otchedwa primary amenorrhea)
- Kusuntha kwa manja awiri nthawi imodzi (kumatchedwa bimanual synkinesis) kumakhudza pafupifupi gawo limodzi mwa asanu mwa amuna omwe ali ndi vutoli
Palinso zizindikiro zina zomwe zimachitika mobwerezabwereza, monga kubadwa ndi impso imodzi kapena kufooketsa mafupa (zofooka mafupa).
Kudziwa
Ngati wina alephera kutha msinkhu, amatumizidwa kwa wodwalayo kuti adziwe kuti ali ndi vutoli. Dokotala wamtundu uwu amadziwika bwino m'mabvuto a mahomoni ndipo amatha kudziwa chifukwa chake msinkhu sichikuchitika.
Pali zifukwa zambiri zomwe zimapangitsa kuti wina asapite msinkhu. Komabe, matenda a Kallmann ndiwo okhawo omwe amawoneka kuti sangathe kununkhiza.
Kawirikawiri zimakhala zosavuta kudziŵa ngati matenda a Kallmann angakhale alipo pogwiritsa ntchito fungo la fungo.
Pali mitundu iwiri ya kuyesera kwa fungo. Mmodzi amagwiritsa ntchito mabotolo ang'onoang'ono omwe ali ndi zinthu zosiyana mwa iwo; mayeso ena amagwiritsa ntchito makadi "scratch ndi sniff". Mayesero onsewo amagwiritsa ntchito zinthu zomwe zimakhala zonunkhira zomwe aliyense amadziwa, monga khofi. Ngati munthu amene akuyesedwa ali ndi fungo labwino, ndiye kuti matenda ena amachokera kuwonjezera pa matenda a Kallmann.
Kufufuza mwakuthupi kumasonyeza ngati mayesero osasangalatsa kapena ziwalo zazing'ono zilipo mwamphongo. Mbiri ya banja la Kallmann matenda ndi chitsimikizo chofunika kuchipeza. Kuyezetsa magazi kumachitika poyeza kuchuluka kwa mahomoni a Luteinizing (LH) ndi hormone yochititsa chidwi (FSH), komanso testosterone kapena estrogen. Mahomoni onsewa ndi ofunikira kukula kwa chiwerewere. Mankhwala otsika kwambiri a ma hormone amatanthawuza kuti pali vuto ndi hypothalamus kapena gland pituitary mu ubongo.
Mu matenda a Kallmann, kusowa kwa fungo kumakhala chifukwa cha kusowa kwa nyumba zomwe zimatchedwa mababu okhwima mu ubongo. Kuwoneka kwa mutu wa magnetic resonance (MRI) wa mutu ukhoza kusonyeza ngati izi zilipo kapena ayi.
Chithandizo
Kuchiza kwa matenda a Kallmann kumaphatikizapo kuchotsa mahomoni omwe akusowa.
Kwa amuna, testosterone kapena hCG amapatsidwa mwa jekeseni panthawi yake. Kwa amayi, mapiritsi a estradiol amatengedwa tsiku ndi tsiku. Mapiritsi a Progesterone amatengedwa tsiku ndi tsiku kwa masiku 14 oyambirira mwezi uliwonse kuti apange msambo. Njira ina yosankhira mitundu iwiri ya mapiritsi ndi kugwiritsa ntchito mapiritsi opatsirana omwe ali ndi estrogen ndi progesterone. Kwa amuna ndi akazi, mankhwala ena alipo chifukwa cha kusabereka. Kuchiza moyenera anthu omwe ali ndi matenda a Kallmann kumawathandiza kuti akhale ndi thanzi labwino la kubereka.
Zotsatira:
> AbuJbara, Mousa, Hanan Hamamy, Nadim Jarrah, > Nadima >> Shegem >, ndi Kamel Ajlouni. "Mbiri zachipatala ndi zolimbana ndi matenda a Kallmann matenda a ku Jordan." Health Reproductive 1 (2004): ePub.
> "Kallmann Syndrome." Nkhani Zachilendo Zambiri. National Organisation for Disorder Disorders. 6 Feb 2008
> Saunders, Mark. "Kumvetsa Kallmann's Syndrome - Mafunso Anu Akuyankhidwa." HYPOHH.net. 1997. HYPOHH.net. 6 Feb 2008