Chitetezo, zotsatira zoyipa, ndi zina
Xolair (omalizumab) ndi mankhwala ophera jekeseni omwe amachititsa kuti thupi likhale lopweteka kwambiri. Ikhoza kugwiritsidwa ntchito kwa anthu 12 kapena kuposerabe omwe ali ndi mphumu yosasinthasintha ngakhale kuti mankhwala omwe amawoneka kuti ndi a mphumu , monga mankhwala opatsirana .
Majekeseni amaperekedwa ku ofesi ya dokotala milungu iwiri kapena inayi malinga ndi kulemera kwake kwa munthu ndi chiwerengero cha anti-antibody (IgE).
(Fufuzani kuti muwone ngati mphumu yanu imayang'aniridwa ndi kutenga mayeso a chifuwa cha mphumu.)
Kodi Chilichonse N'chiyani?
Xolair ndi anti-IgE anti-anti-IgE yomwe imamangiriza ku IgE m'magazi, kuti thupi lichotse. Mankhwalawa amapangidwa mu mbewa ndipo motero ali ndi mapuloteni pafupifupi asanu peresenti ya phokoso (sizikuwoneka kuti mankhwala okhudzana ndi mapuloteni amachititsa mavuto kwa anthu omwe amalandira Xolair).
Izi zimalepheretsa IgE kusakanikirana ndi maselo akuluakulu ndi kumangiriza zizindikiro, zomwe zimadzetsa kumasulidwa kwa histamine ndi mankhwala ena. Ndi mankhwala awa omwe amachititsa kuipa kwa mphumu ndi zizindikiro zina zozizira.
Mankhwalawa asonyezedwa kuti achepetse kuthamanga kwa mphumu, kuchepetsa umoyo wonse wa moyo kwa anthu omwe ali ndi mphumu, ndipo amachepetsa corticosteroids . Kawirikawiri, zingatenge miyezi ingapo ya jekeseni ya Xolair kuti igwire ntchito. Ndipo mankhwala akhoza kukhala okwera mtengo kwambiri.
Xolair si mankhwala a chifuwa cha mphumu chiyenera kuwonjezereka patapita miyezi ingapo chithandizo cha Xolair chitayimitsidwa.
Kodi Kutenga Xolair Kuwopsa?
Xolair pakali pano ili ndi chenjezo la "black box", lomwe ndilo tcheru loperekedwa kwa mankhwala a US Food and Drug Administration (FDA). Chenjezoli lachitika chifukwa cha mauthenga a anthu omwe ali ndi anaphylaxis (osamva kanthu) atalandira Xolair.
Ngakhale kulibe malipoti a kufala anaphylaxis chifukwa cha Xolair, zochitika zina zakhala zoopsa ndipo zingathe kupha moyo. Pachifukwa ichi, a FDA amafuna kuti anthu omwe alandira Xolair ayang'anire ku ofesi yawo ya dokotala kwa nthawi ndithu pambuyo pa jekeseni wawo. (Nthawi yeniyeni yodziwika ndi dokotala.)
Anthu omwe amalandira Xolair ayenera kuyang'ana zizindikiro zotsatirazi za anaphylaxis, zomwe zingachitike mpaka maola 24 (kapena patapita) jekeseni:
- Kupuma, kupuma pang'ono, kukokera, chifuwa, kapena kupuma
- Kuthamanga kwa magazi, chizungulire, kutaya, kufulumira kapena kufooketsa mtima
- Kupuma, kuyabwa, ming†™ oma, kapena kutupa
- Nseru , kusanza , kutsegula m'mimba , kapena ululu wamimba
- Kutupa mmero, lilime, milomo, kapena maso
- Kuthamangitsani kumveka, kumveka mawu, vuto kukumeza
- Mwadzidzidzi kunjenjemera kwakukulu, mphuno yothamanga, kapena kusokonezeka kwa msana
- Nkhawa kapena mantha
Ngati zizindikirozi ziyenera kuchitika, nkofunika kudziwitsa dokotala wanu mwamsanga. Madokotala ambiri amapereka odwala okhala ndi jekeseni epinephrine kuti agwiritse ntchito ngati anaphylaxis maola 24 mutapatsidwa jekeseni wa Xolair.
Kuopsa kwa Khansa
Pa chitukuko chachipatala, chiwerengero cha khansa chinali chapamwamba kuposa anthu omwe amalandira Xolair poyerekeza ndi anthu omwe ali ndi jakisoni la placebo.
Mitundu ya khansa yomwe imapezeka mwa anthu omwe amalandira Xolair ndi khansa ya m'mawere, khansara ya khungu, ndi kansa ya prostate. Sitikudziwikanso chomwe zotsatira za nthawi yaitali za Xolair zingakhale ndi anthu omwe angathe kutenga khansa, monga okalamba.
Ngakhale zikuoneka kuti Xolair imakhala ndi zotsatira zoyipa, ziyenera kukumbukiridwa kuti anaphylaxis ndi kansa zimachitika pokhapokha ochepa odwala. Sichikudziwika chifukwa chake zotsatirazi zimachitika, ngakhale kuti maphunziro akupitiriza kudziwa chifukwa chake.
Ndikofunikira kuzindikira kuti mphumu yosatetezedwa ingabweretse mavuto aakulu, kuphatikizapo imfa.
Ndipo mankhwala omwe amachiza matenda a mphumu, monga odwala ndi odwala corticosteroids, ali ndi mndandanda wa zowononga ndi ntchito yayitali. Choncho, ndi kofunika kukambirana ndi dokotala zowopsa ndi phindu la kutenga Xolair chifukwa cha mphumu yomwe siidayendetsedwa pa mankhwala omwe ali ndi chifuwa cha mphumu.
Xolair ya Mavuto Ena
Kafukufuku wosiyanasiyana anafufuza ubwino wa Xolair pochiza matenda a idiopathic urticaria (mng'oma), kapena CIU. Kafukufuku waposachedwapa anafufuza odwala oposa 300 omwe ali ndi CIU omwe adakali ndi zizindikiro ngakhale kuti amamwa mankhwala oletsa antihistamines.
Zigawo zimaperekedwa ndi Xolair m'mayeso osiyanasiyana milungu iwiri iliyonse. Anthu makumi anai ndi anayi omwe amalandira dola Xolair yapamwamba, ndipo 22 peresenti ya anthu omwe amalandira chithandizo cha sing'anga Xolair, anali ndi ming'oma yamkati mwa masabata awiri mpaka awiri. Zizindikirozo zinapitirira pang'onopang'ono pambuyo pa Xolair ataimitsidwa, motero panalibe chizindikiro chokhala ndi phindu la nthaŵi yaitali. Mu March 2014, a FDA adavomereza kugwiritsa ntchito Xolair kwa CIU.