Zotsatira za Vitamini C May Mayendedwe pa Malignancy
Mukamaganizira za kupsinjika maganizo, mwinamwake maganizo anu amatembenukira ku ndandanda, nthawi, zoyezetsa, maubwenzi, kapena mavuto ena omwe munthu angakumane nawo pamoyo wake. Dziko lapansi lerolino liribe kusowa kwa zovuta zowopsya.
Komabe, sikuti munthu aliyense amachitanso chimodzimodzi kwa otsogolera awa. Zomwe zimachokera pa kusiyana kwa munthu aliyense zimakhala zambiri, mbali imodzi chifukwa cha kuthekera kwathu kupirira ndikuyankha moyenera ku malo athu.
Pali mafananidwe a maselo ndi nkhawa, komanso. Monga momwe tingapezere malo athu ovuta nthawi zina, malo a selo angakhale ndi mitundu yosiyanasiyana ya zovuta zomwe zimayambitsa-mwachitsanzo, molecule yodetsa nkhaŵa m'madzi oyandikana nawo, kapena osakhoza kupanga makompyuta a mkati mwawo bwino.
Pamene mukuganiza za maselo a khansa, makamaka, simungayanjane nawo nthawi yomweyo ndi chiopsezo chachikulu cha kupsinjika. Selo la khansa nthawi zambiri limafotokozedwa ndi mawu monga 'osadziŵika' ndi 'osakhoza kufa' chifukwa amawoneka kuti amaberekana ndi kufalikira popanda malire. Komabe, zimapezeka kuti maselo a kansa amagwira ntchito panthawi yachisokonezo chachikulu, makamaka kupsyinjika kwa okosijeni. Ndipo vitamini C ikhoza kugwira ntchito yofunika kwambiri pakubwera kwa mazira ena omwe amathandiza maselo kuthana ndi vuto.
Kodi Kupanikizika Kwambiri Ndi Chiyani?
Maganizo okhudzana ndi oxidative , mwachindunji, ndi kusamvetsetsana m'mabwalo am'manja.
Pamene lingaliroli likupitsidwanso patsogolo, kusamvetseka kumeneku kungawonedwe ngati nkhondo yosiyana pakati pa kupanga mdani woipa (mphamvu zowonongeka) ndi mphamvu ya thupi kuteteza zotsatira za mdani uyu (kudzera mwa antioxidants).
Mwinamwake mwaphunziranso za anthu ochita masewera olimbitsa thupi mu khemistri: mwamalamulo, iwo amatchulidwa ngati maziralekiti osatulutsidwa omwe nthawi zambiri amakhala otetezeka komanso osakhalitsa, ndi ma electron osayendetsa.
Mwachitsanzo, maselo a mpweya m'thupi nthawi zina amagawanika kukhala ma atomu amodzi a oksijeni, aliyense ali ndi ma electron osagwedezeka.
Ma electron akufuna kukhala awiriawiri, choncho maatomu osagwirizana, omwe tsopano amatchedwa kuti radical free, amafuna magetsi ena omwe ali gawo la thupi, pafupifupi ngati zowononga, kuti azigwirizana ndi electron yomwe ili ya molekyulu ina mu thupi. Izi ndizowonjezereka, ndipo zimayambitsa maselo, ma membrane, mapuloteni ndi DNA.
Kotero, nchifukwa ninji maselo a khansa amagwira ntchito pansi pa msinkhu wambiri wachisokonezo cha okosijeni? Chabwino, kawirikawiri maselowa ali ndi zida zapamwamba pamasewero, kuyamba pomwe, asanakhale ndi khansa. Ndiye, monga selo limatengera njira zowonjezera kuti zikhale ndi khansa, zinthu zimasintha mwa momwe momwe selo ilo liriri lokha lomwe limayambitsa kagayidwe kake, zomwe zingabweretse mowonjezereka kwambiri zowonongeka kwaulere.
Kawirikawiri, pali kusiyana pakati pa kupanga komanso kuchotsa kwaulere. Pali magulu awiri osiyana, omwe ali ndi timagulu tomwe timapanga tizilombo toyambitsa matenda monga superoxide anion (O2-), hydrogen peroxide (H2O2), hydroxyl radicals (OH-), ndi zina zotero, ndipo gulu lina likupereka antioxidant njira zotetezera [superoxide dismutase ( SOD), catalase (CAT), glutathione peroxidase (GPx), ndi zina zotero].
Pamene mdani wodalirika waufulu sali woyenera komanso / kapena kuchotseratu, zotsatira zake zingakhale zowonongeka kwa maselo, kutayika kwa ntchito komanso kukhulupirika kwa selo, ndi kuwonongeka kwa DNA, kulimbikitsa kusintha kwa mazira ndi kuwonjezeka kwa selo. Izi zimatchedwa kuti zovuta zamtunduwu, ndipo zimatha kuwonjezera moto pamoto woyendetsa selo.
Zosintha zamadzimadzi komanso zowonongeka zazitsulo zimayanjananso ndi matenda ambiri a anthu kupatula khansara, kuphatikizapo matenda a mtima, matenda a Alzheimer, matenda a Parkinson, ndi zina zambiri. Palinso mgwirizano wokhudzana ndi kukalamba, ndi kuwonjezereka kochepa kwa kuwonongeka kwaulere.
Zomwe zimapanga zowonjezera zowonjezera zingapezedwe kumalo athu, kuphatikizapo zakudya zomwe timadya, komanso zimapezeka m'matupi athu monga zinthu zachibadwa za thupi.
Kodi Zingatheke Bwanji Mavitamini C Kuteteza Khansa?
Vitamini C yayesedwa mu maphunziro osiyanasiyana a chithandizo ndi kupewa khansara; Komabe, zotsatira sizikuwonekera nthawi zonse. Mayankho a funso la udindo wa vitamini C mu katetezedwe ka khansa ndi chithandizo angadalire malingaliro enieni-ndi mlingo wa vitamini C, mwa zina.
Mavitamini ochepa, vitamini C ali ndi mphamvu yoletsa antioxidant, kuteteza mchere. Zakudya za antioxidant, zowonjezera ku ascorbic acid (vitamini C), carotenoids (vitamini A) ndi tocopherol (vitamini E), selenium, ndi flavonoids, zimalimbikitsidwa chifukwa cha zomwe amatsutsa poletsa kutsekemera kwa okosijeni ndi kupanga zopanda pake.
Komabe, mavitamini C angapangitse kuchulukitsa kwa ATP (yotengedwa ndi mitochondria) yomwe imapangitsa kuti maselo a maselo apangidwe apitirize kuyesedwa, pogwiritsa ntchito njira yothandizira.
Kafukufuku amasonyeza kuti amadwala matenda a khansa omwe amachititsa mitundu yosiyanasiyana ya maselo kuphatikizapo maselo omwe amachititsa kuti maselo azifa, kukula kwa maselo, komanso kuwonetsa maselo, kuphatikizapo khansa yowonjezera kufala mu ma labulo omwe amayambitsa khansa ndi mitoxantrone (chemotherapy drug) pamodzi ndi vitamini C .
Kodi Padzakhala Udindo wa Mlingo Wambiri wa Vitamini C mu khansa ya m'magazi?
Pakalipano, kafukufuku wina wanena kuti ntchito yolimbana ndi mitundu yambiri ya khansa, koma kafukufuku wina wanena kuti vitamini C ikhoza kupanga chemotherapy mopanda mphamvu.
Yankho laling'ono la funsoli ndi "mwina," komanso, "lingadalire ndi khansa ya m'magazi." Zingakhale zofunikira kuyang'ana vitamini C kuchokera m'magulu osiyanasiyana musanaganize za ntchito yake mu khansara iliyonse, koma ena Zofufuza zoyambirira kuchokera ku kafukufuku wopangidwa ndi ma laboratory za hematologic malignancies zimalimbikitsa.
Phunziro la 2017 la zotsatira za vitamini C pa maselo a leukemia linasindikizidwa mu nyuzipepala yakuti "Cell." Poyambirira, olembawo adanena kuti umboni wa vitamini C ngati mankhwala ochizira khansa wakhala ukutsutsana mpaka pano.
Vitamini C Mayamadzi Othandiza Amagazi Amtengo Wapatali mu khansa ya m'magazi
Makamaka, kagulu kameneka kafukufuku anafufuza kusintha kwa majini mumtundu wa Tet (Ten Eleven Translocation) methylcytosine dioxygenase 2, kapena TET2. Anapeza kuyanjana ndi vitamini C ndi machitidwe ena a ma enzyme omwe amawoneka kuti akuwathandiza kwambiri mankhwala ena a khansa. Ichi chinali phunziro la zinyama, motero zofunikira kwa anthu sizidziwikabe, koma zotsatira zake zinali zosokoneza.
Mu thupi, maselo atsopano a magazi amachokera ku maselo apadera mu fupa la mafupa omwe amatchedwa maselo a hematopoietic. Maphunziro oyamba asonyeza kuti tizilombo toyambitsa matenda a TET2 amatha kupanga maselo otetezeka kukhala maselo abwino, okhwima, achibadwa amagazi-maselo omwe amatha kufa chimodzimodzi ndi selo lina lililonse. Mosiyanako, mu khansa ya m'magazi, maselo amkati samakula bwino, koma amadzipangitsa okha, kuwonjezeka m'magulu ovulaza a maselo a copycat.
Zotsatira za matenda osapitirira malire a khansa ya m'magazi zimateteza kuti thupi lisapange maselo okwanira, omwe amachititsa kuti thupi lawo liziyenda bwino. kuchepa kwa maselo ofiira atsopano kungapangitse ku kuchepa kwa magazi, komanso. Choncho, chiwopsezo cha matenda ndi zinthu monga kufooka kapena kupweteka kwa magazi m'thupi nthawi zambiri zimakhala zizindikiro ndi zizindikiro za khansa ya m'magazi.
Zili choncho kuti nthawi zina matenda a khansa ya m'magazi, asinthika, kapena kusintha, komwe kumachititsa kuti tizilombo toyambitsa matenda TET2 sagwire ntchito bwino. Choncho, kafukufuku wa 2017 anafufuzanso njira zomwe tizilombo toyambitsa matendawa, TET2, tingalimbikitsidwe kuti tichite ntchito yake, makamaka makamaka ngati vitamini C ingagwiritsidwe ntchito pofuna kuyambitsanso maselo abwino.
Vitamini C TET2 Zotsatira Zophunzira
Ochita kafukufuku anapanga makoswe kuti atsegule tizilombo TET2, ndipo adapeza kuti pamene TET2 inazimitsidwa, maselo ofunika anayamba kuwonongeka, ndipo atatembenuza jini, izi zinasinthidwa.
Mu khansa ya m'magazi ndi matenda ena amagazi omwe angakhudzidwe ndi kusintha kwa majini kumakhudza mavitamini a TET2, imodzi yokha ya makope awiri a TET2 imasinthidwa. Ofufuzawo amayang'ana ngati vitamini C ikhoza kukonzekera jini yoyipa, yosinthidwa, kapena yosinthidwa mwa kupititsa patsogolo ntchito yakopi yomwe idakagwiranso ntchito. Iwo adapeza kuti ndi vitamini C, adalimbikitsa kwambiri mafupa omwe anabwezeretsa TET2 ntchito.
PARP-inhibitors monga olaparib ndi mankhwala omwe akuphunziridwa kuti athe kugwiritsa ntchito mitundu yambiri ya khansa ya magazi ndi khansa ya m'magazi. Mu phunziroli, ofufuza anaphatikiza vitamini C ndi PARP inhibitors mu zitsanzo zawo zanyama kuti aphunzire mgwirizano. Iwo adapeza kuti mgwirizanowu wagwiritsidwa ntchito molimbika, zomwe zimapangitsa kuti zikhale zovuta kwambiri kuti maselo obwera chifukwa cha khansa ayambe kukonzanso.
Nanga bwanji Vitamini C mu Lymphoma?
Monga momwe anapeza ku khansa ya m'magazi, kafukufukuyu ali panthawi yachipatala, kutanthauza kuti zomwe timadziwa zimachokera ku mayesero a maselo ndi zinyama mu laboratories, koma osati payekha m'mayesero a zachipatala.
Komabe, pali, pogwiritsa ntchito deta izi zisanachitike, zifukwa zokhulupirira kuti zofufuza zokhudzana ndi TET2 ndi vitamini C zingagwiritsidwe ntchito pa zochitika zina za lymphoma .
Mu lymphoma, matembenuzidwe a TET2 amapezeka kawirikawiri m'matenda a t-cell. Mu lymphoma subtype, angioimmunoblastic T-cell lymphoma , TET2 ingasunthidwe mwa odwala 76 peresenti ya odwala. Mtengo wa TET2 umakhala wolemera kwambiri pa 38 peresenti ya odwala okhala ndi T-cell lymphoma-osatchulidwa mwatsatanetsatane, malinga ndi kafukufuku wina wa Lemonnier ndi anzake, ndipo 13 peresenti ali m'gulu lalikulu la B-cell lymphoma .
Mawu Ochokera
Ngakhale asayansi asanthula ma data okhudzana ndi vitamini C ndi momwe angathere kuti athetse khansa, ndikofunikira kuti muyambe kudya mavitaminiwa moyenera. Zambiri za chinthu chabwino sizinali zabwino. Ndipo, nthawi zonse ndi bwino kukaonana ndi dokotala mukamayambitsa zina zowonjezera zomwe zingasokoneze chithandizo chanu.
Palibe umboni uliwonse womwe umasonyeza kuti kupatsirana ndi vitamini C nokha, kupitirira zomwe akulimbikitsidwa, kudzatetezedwa kapena kungapindule kwambiri ndi khansa ya m'magazi kapena lymphoma, ndipo kudziyesa koteroko kungathe kuvulaza nthawi zina.
M'maphunziro apitalo, tawonetsa kuti odwala omwe ali ndi matenda a hematologic amatha kukhala opanda vitamini C. Choncho, kuthetsa vuto lililonse la vitamini C lingakhale malo abwino oyamba.
> Zotsatira:
> Cimmino L, Dolgalev I, Wang Y, et al. Kubwezeretsedwa kwa ntchito ya TET2 kumapangitsa kuti munthu azidzipangira yekha komanso kuti ayambe kupuma. Cell . 2017 Aug 16. pii: S0092-8674 (17) 30868-1. lembani: 10.1016 / j.cell.2017.07.032. [Epub patsogolo pa kusindikiza].
> Lemonnier F, Couronne L, Parrens M, et al. Kusintha kwatsopano kwa TET2 mumtundu wa T-cell lymphomas kumagwirizana ndi zizindikiro za TFH ndi zovuta zapadera. Magazi. 2012; 120: 1466-1469.
> Mikirova N, Casciari J, Rogers A, et al. Zotsatira za mlingo wapamwamba kwambiri wa vitamini C pa kutupa kwa odwala khansa. J Kutanthauzira Med . 2012; 10: 189.
> Shenoy N, Bhagat T, Nieves E, et al. Kupititsa patsogolo ntchito za TET ndi ascorbic acid kumapangitsa kuti maselo a lymphoma asinthe. Magazi a Magazi J. 2017; 7 (7): e587-. lembani: 10.1038 / bcj.2017.65.