Alpha-ketoglutaric acid ndi chinthu chopezeka mwachibadwa m'thupi la munthu. Komanso pamapezeka zakudya zowonjezerapo, alpha-ketoglutaric acid imakhala ndi gawo lofunika kwambiri pa kayendetsedwe ka Krebs (njira zosiyanasiyana zomwe zimachitika m'thupi kupanga mphamvu). Mafuta a alpha-ketoglutaric acid amaperekedwa kuti apereke ubwino wathanzi.
Alpha-ketoglutaric acid imapezedwanso mu mchere, monga chinthu chotchedwa alpha-ketoglutarate.
Alpha-ketoglutarate ikuphatikizidwa kupanga mapangidwe a glutamine, amino acid omwe amafunikanso kuti apange mapuloteni komanso kugwiritsa ntchito bwino chitetezo cha mthupi.
Ntchito
Alpha-ketoglutaric acid nthawi zambiri imatchulidwa kuti imapangitsanso masewera olimbitsa thupi. Anthu ena ochizira mankhwala amanena kuti kugwiritsa ntchito alpha-ketoglutaric acid kungathandize kulimbikitsa thupi kupanga mapuloteni, kuchepetsa shuga m'magazi pa nthawi yochita masewera olimbitsa thupi, ndi kupititsa patsogolo kupirira.
Mu njira zamankhwala, alpha-ketoglutaric acid imanenedwa kuti imathandizira ndi matenda awa:
- matenda opatsirana
- nthata
- matenda a impso
- matenda a yisiti
Ubwino
Ngakhale kuti kafukufuku wokhudzana ndi thanzi la alpha-ketoglutaric acid ndi lochepa kwambiri, kafukufuku wina woyambirira amasonyeza kuti alpha-ketoglutarate ingapereke ubwino wathanzi. Pano pali kuyang'ana pa zifukwa zingapo zofunika kuchokera ku maphunziro omwe alipo:
1) Hemodialysis
Alpha-ketoglutarate ingakhale yopindulitsa kwa anthu omwe amachititsa hemodialysis.
Pa kafukufuku wofalitsidwa m'nyuzipepala ya Nephron mu 1996, ofufuza adapeza kuti kugawa al-ketoglutarate ndi calcium carbonate kwa odwala a hemodialysis kunathandiza kulimbitsa amino acid metabolism ndikuchepetsanso hyperphosphatemia (chikhalidwe chokhala ndi phosphate m'mwamba mwazidzidzidzi).
2) Opaleshoni ya mtima
Alpha-ketoglutarate ingathandize kuthetsa ntchito ya impso pakati pa odwala opaleshoni ya mtima, malinga ndi kafukufuku wa 1998 wochokera ku Annals of Thoracic Surgery . Phunziroli linaphatikizapo anthu 22 omwe ali ndi matenda a impso asanayambe kuchitidwa opaleshoni ya mtima. Mwa odwalawo, anthu 11 analandira kulowetsedwa m'magazi kwa alpha-ketoglutarate ola limodzi pambuyo pa opaleshoni yawo. Zotsatira zaphunziro zimasonyeza kuti alpha-ketoglutarate ikhoza kupititsa patsogolo kuthamanga kwa magazi mu impso.
3) Zaka zambiri
Phunziro la 2014 lofalitsidwa mu Nature limasonyeza kuti alpha-ketoglutarate ikhoza kusonyeza lonjezano kuwonjezereka kwa moyo wautali. Poyesedwa pa nematode nyongolotsi Caenorhabditis elegans , olembawo apeza kuti alpha-ketoglutarate imasokoneza kupanga mphamvu zamagetsi ndipo imayesa zotsatira za zakudya zochepa kwambiri m'makilogalamu, zomwe zasonyezedwa kuti zowonjezera moyo wa nyama zina. Malingana ndi olembawo, alpha-ketoglutarate yowonjezera moyo wa mphutsi zomwe zimagwiritsidwa ntchito pafupifupi 50% pazitsulo zosasinthidwa. Phunziro lina likufunika kuti muwone zotsatira zake zomwe zimakhala ndi anthu.
Mipango
Chifukwa cha kusowa kwa kafukufuku, pang'ono sadziwika za chitetezo cha nthawi yaitali kapena ntchito nthawi zonse zowonjezereka zomwe zili ndi alpha-ketoglutaric acid.
Komabe, pali vuto linalake kuti kugwiritsa ntchito alpha-ketoglutaric acid kungakhumudwitse mimba komanso / kapena kukhumudwitsa m'mimba.
Ndikofunika kukumbukira kuti zowonjezereka sizinayesedwe kuti zisawonongeke komanso zakudya zowonjezera zakudya sizingalekeke. Nthaŵi zina, mankhwalawa amatha kupereka mankhwala omwe amasiyana ndi ndalama zomwe zimayikidwa pazitsamba iliyonse. Nthawi zina, mankhwalawa akhoza kuipitsidwa ndi zinthu zina monga zitsulo. Komanso, chitetezo cha mankhwala opatsirana mwa amayi apakati, amayi oyamwitsa, ana, ndi omwe ali ndi matenda kapena omwe akumwa mankhwala sanakhazikitsidwe.
Mukhoza kupeza malangizo othandizira kugwiritsa ntchito zowonjezerako apa .
Njira Zina
Njira zina zamakono zingakhale zogwiritsira ntchito popititsa patsogolo masewera. Mwachitsanzo, kafukufuku wina amasonyeza kuti nthambi za amino acid zimathandizira kuti thupi lizikhala bwino komanso kuti asatope nthawi yayitali.
Kuonjezerapo, phosphatidylserine yowonjezeretsa mphamvu yowonjezera, imachepetsanso kupweteka kwa minofu ndi kuteteza kuwonjezeka kwa magulu a cortisol (hormone yomwe imatulutsidwa mu nthawi yachisokonezo) yomwe nthawi zambiri imachokera chifukwa cha kupititsa patsogolo.
Palinso umboni wina wakuti chilengedwe chingalimbikitse kugwira ntchito mwamphamvu kwambiri, ntchito zochepa (monga kulemera-kutsika ndi sprinting).
Kumene Mungapeze
Zogula kugula pa intaneti, alpha-ketoglutaric acid imagulitsidwa m'masitolo ambiri achilengedwe, mankhwala osokoneza bongo, ndi malo ogulitsa zakudya zowonjezera zakudya.
Mawu Ochokera
Chifukwa cha kafukufuku wochepa, ndiposachedwa kwambiri kuti alangize alpha-ketoglutaric acid pamtundu uliwonse. Ndikofunika kuzindikira kuti kudzipiritsa nokha ndi thanzi la alpha-ketoglutaric acid ndi kupeŵa kapena kuchedwetsa chisamaliro choyenera kungakhale ndi zotsatira zoopsa. Ngati mukuganiza kuti mugwiritse ntchito, onetsetsani kuti mufunsane ndi dokotala wanu.
Zotsatira
Chimango, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Vesi VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. "The α-ketoglutarate ya metabolite imatulutsa moyo poletsa ATP synthase ndi TOR." Chilengedwe. 2014; 509 (7500). dx.doi.org/10.1038/nature13264
Jeppsson A, Ekroth R, Friberg P, Kirnö K, Milocco I, Nilsson FN, Svensson S, Wernerman J. "Zotsatira za alpha-ketoglutarate musanayambe kugwira ntchito." Ann Thorac Surg. 1998 Mar; 65 (3): 684-90.
Riedel E, Nündel M, Hampl H. "Mankhwala a Alpha-Ketoglutarate m'magulu a hemodialysis amachititsa kuti amino acid metabolism." Nefron. 1996; 74 (2): 261-5.
Chodziwikiratu: Zomwe zili pa tsambali zimapangidwa pazinthu zophunzitsira zokha ndipo sizilowetsamo malangizo, matenda kapena chithandizo ndi dokotala wololedwa. Sichikutanthauza kubisa zonse zomwe zingatheke, kuyanjana kwa mankhwala, zochitika kapena zotsatirapo zoipa. Muyenera kupeza chithandizo chamankhwala mwamsanga pa nkhani iliyonse yathanzi ndikufunsani dokotala musanagwiritse ntchito mankhwala osakaniza kapena kusintha kwa regimen yanu.