Kodi ma telomere amatha kufotokoza kukalamba?
Kutulukira kwa telomere kunasintha kwambiri momwe kafukufuku amawerengera moyo wautali ndi ukalamba. Ndipotu, ofufuza omwe anapeza ma telomere anapambana Nobel Prize Physiology kapena Medicine mu 2009. Ma telomeres ndi mabwinja a "DNA yopanda kanthu" yomwe ili pamapeto a chromosomes . Amateteza DNA yanu nthawi iliyonse pamene selo limagawanika.
Nthawi iliyonse selo ligawanika, DNA imatuluka, ndipo chidziwitso cha mkati chimakopedwa.
Chifukwa cha momwe maselo amagawikana, chromosome yotsiriza yotsiriza, telomere, silingathe kulembedwa kwathunthu. Zing'onozing'ono ziyenera kuchotsedwa. Zikuganiziridwa kuti, monga selo limagawanika, telomere zikhale zazifupi ndi zazifupi nthawi iliyonse mpaka zitatha. Panthawi imeneyi, DNA yomwe imatchedwa "yeniyeni" silingakopedwenso, ndipo selo limangokhala zaka zambiri ndipo silingathe kufotokozanso.
Kodi Kafukufuku Amati Chiyani Ponena za kuchepetsa ndi Kukalamba kwa Telomere?
Mu maphunziro a msinkhu wa anthu, ofufuza apeza kuti anthu achikulire ali ndi telomere zazifupi. Pomalizira pake, maselo okhala ndi tambala tating'ono sangathe kubwereza. Izi zimakhudza maselo ambiri ndi nthawi, zomwe zimapangitsa kuwonongeka kwa minofu ndi zizindikiro zoopsya.
Maselo ambiri amatha kusinthira pafupifupi 50 ma telomere asanakhale achifupi kwambiri. Ochita kafukufuku ena amakhulupirira kuti telomere ndi "chinsinsi chokhala ndi moyo wautali" komanso kuti nthawi zina ma telomere sadzafupikitsa.
Mwachitsanzo, maselo a khansa samwalira (omwe ndi vuto lalikulu) chifukwa amachititsa kuti tizilombo toyambitsa matenda tiyambe kutchedwa telomerase yomwe imawonjezera ma telomere pamene maselo agawanika.
Maselo onse m'thupi ali ndi mphamvu yotulutsa telomerase, koma maselo enaake-kuphatikizapo maselo am'mimba, maselo a umuna, ndi maselo oyera a magazi - amafunikira kupanga mavitamini.
Maselowa amafunika kupindula maulendo oposa 50 m'moyo wawo wonse, motero popanga telomerase sakhudzidwa ndi kuchepetsedwa kwa telomere.
Zizindikiro zochepa kwambiri sizimangogwirizana ndi msinkhu koma ndi matenda. Ndipotu, ntchito yotalikirapo yotchedwa telomere kutalika ndi yotsika yotchedwa telomerase ikugwirizanitsidwa ndi matenda angapo osatetezeka. Izi zimaphatikizapo kuthamanga kwa magazi, matenda a mtima, insulini kukana, mtundu wa shuga 2, kuvutika maganizo, kufooka kwa thupi, ndi kunenepa kwambiri.
Kodi Aliyense Amachita Zimenezi?
Ayi. Ndizodabwitsa kwambiri. Ofufuza ku Sweden anapeza kuti ma telomere a anthu ena samangotenga nthawi yochepa. Ndipotu, anapeza kuti ma telomere ena amatha kutenga nthawi yaitali. Kusiyana kumeneku pa msinkhu uliwonse kunali kosatheka kudziwika ndi maphunziro omwe asanakhalepo omwe zotsatira zake zinalipo pa chiwerengero chachikulu.
Phunziroli, anthu okwana 959 adapereka magazi kawiri, zaka zisanu ndi ziwiri ndi zisanu ndi ziwiri. Pafupifupi, zitsanzo zachiwiri zinali ndi zilembo zazifupi kuposa zoyamba. Komabe, pafupifupi 33 peresenti ya ophunzirawo anali ndi khola lakale kapena lowonjezera la telomere kwa zaka pafupifupi 10.
Kodi izi zikutanthauza chiyani? Izo siziri bwino. Zingakhale kuti anthu amenewo ali ndi njira zodabwitsa zokhudzana ndi kukalamba; zikhoza kukhala kuti ali ndi chizindikiro choyamba cha khansa (ofufuza amayesa kulamulira izi), kapena zingakhale zopanda phindu.
Zimene timadziwa ndizakuti ukalamba ndi wovuta kwambiri kuposa kungoyang'ana kuchepetsedwa kwa telomere.
Mawu Ochokera
Chiphunzitso cha telomere ndi chimodzi mwa ziphunzitso za ukalamba . Iyi ndi gawo lotukuka, ndipo zatsopano zopezeka zingatsutse izo kapena zingayambitse kugwiritsa ntchito chiphunzitsochi kuti apange chithandizo cha matenda ndi zikhalidwe.
> Zotsatira:
> Nordfjäll K, Svenson U, Norrback KF, Adolfsson R, Lenner P, Roos G. Mlingo wokhawokha wa maselo owonetsera magazi ndi telomere kutalika kwake. PLoS Genetics, February 13, 2009 Kodi: 10.1371 / journal.pgen.1000375