Viscosupplement Kubwezeretsa Zida Zamadzimadzi Omwe Amagwirizanitsa
Synvisc (hylan GF 20) ndi zotsekemera, zowonongeka, zamadzimadzi zolemera zamadzimadzi zomwe ziri ndi hylan Madzi, madzi a Gel, ndi madzi amchere. Hylan A ndi hylan B zimachokera ku hyaluronan (yotchedwa sodium hyaluronate) yomwe imapangidwa kuchokera ku nkhuku zisa. Hyaluronan ndi chinthu chachilengedwe chomwe chimapezeka m'thupi, makamaka, muzambiri.
Hyaluronan ya thupi la thupi limakhala ngati mafuta ndi zotsekemera zomwe zimafunika kuti azigwiritsidwa ntchito limodzi.
Synvisc ndi imodzi mwa hyaluronates yomwe imagwiritsidwa ntchito pa chithandizo chodziwika kuti viscosupplementation . Nthawi zina mankhwalawa amatchedwa mankhwala ophatikizana, hyaluronan injection, kapena jekeseni ya hyaluronate.
Zisonyezo za Synvisc
Majekeseni a Synvisc amavomerezedwa kuti athe kuchiritsidwa ndi odwala osteoarthritis a bondo omwe alephera kuyankha mankhwala othandizira, monga mankhwala osokoneza bongo kapena zosakondera mankhwala. M'magulu a osteoarthritis, pangakhale kusakwanira kwa hyaluronan kapena ubwino wa hyaluronan ukhoza kuchepa. Kugwiritsa ntchito Synvisc kwa ziwalo zina ikufufuzidwa, koma sikunayambe kuvomerezedwa.
Synvisc imayikidwa, pogwiritsira ntchito sirinji yomwe ili ndi 2 ml, mwadongosolo molumikizana ndi mawondo kuti abwezeretse malo osakaniza ndi odzola omwe amadziwika nawo.
Palinso chinthu china chotchedwa Synvisc, chomwe chimatchedwa Synvisc-One, chomwe chimaperekedwa ngati jekeseni imodzi (imodzi) intra-articular (6 ml).
Zotsatira za Synvisc - Chiyambi
- Viscosupplementation yaphunziridwa chifukwa cha matenda osteoarthritis kuyambira m'ma 1970.
- Synvisc ndi FDA yovomerezeka pa 08/08/97.
- Majekeseni a Synvisc amaperekedwa ngati majekesiti atatu, kamodzi pa sabata, sabata imodzi yokha. Synvisc-One inakhazikitsidwa ngati jekeseni la nthawi imodzi, monga njira yotsatila ya zitatu ndi Synvisc.
- Pofuna kupeza zotsatira zabwino, osteoarthritic synovial madzi amachotsedwa pa bondo musanayambe jekeseni yoyamba.
- Synvisc imatengedwa ngati mankhwala kapena mankhwala, osati mankhwala.
Zotsatira Zotsatira ndi Ngozi
Zotsatira zofala kwambiri zomwe zimagwirizanitsidwa ndi jakisoni wa Synvisc zimapweteka mu bondo lotayidwa, kutupa mu bondo lotayidwa, ndi kuyanjana . Zina zomwe zingakhale zovuta zomwe zingakhalepo ndi injini za intra-articular zimaphatikizapo arthralgia (kupweteka mu mgwirizano), kupsinjika kwa mgwirizano, kuthamangitsidwa kwa mgwirizano, kutentha kwa palimodzi, kutentha kwa mgwirizano , kupweteka pa malo opangira jekeseni, nyamakazi, nyamakazi, ndi zachilendo.
Kuwonetserana kwa malonda a mtundu wa 3-jekeseni wa Synvisc unavumbulutsira zovuta zina zomwe zimakhalapo monga kuphwanya, ming'oma, malungo, kunyowa, kupweteka kwa mutu, chizungulire, kukhumudwa, kupwetekedwa kwa minofu, malaise , matenda opuma, pulogalamu ya palimodzi, komanso nthawi zambiri, thrombocytopenia ).
Zotsutsana ndi machenjezo
Synvisc sayenera kupatsidwa jekeseni kwa odwala omwe amadziwika kuti hypersensitivity kwa mankhwala a hyaluronan. Komanso, Synvisc sayenera kuyikidwa m'magazi ndi matenda opatsirana, matenda a khungu kapena matenda, kapena matenda m'deralo lozungulira malo ojambulidwa.
Synvisc iyenera kugwiritsidwa ntchito monga injection ya intra-articular (mkati mwa mgwirizano).
Ngati jekeseni kunja kwa mgwirizano mu minofu ya synovial kapena capsule yowonjezera, zochitika zowonongeka zapanyumba kapena zowonongeka zingathe kuchitika. Jekeseni yambiri ya Synvisc (kulowa mu zotengera zamagazi) ingayambitse zochitika zowonongeka ndipo ziyenera kupeĊµa.
Pambuyo pa jekeseni la Synvisc, ndibwino kuti odwala azipewa ntchito zovuta kapena ntchito zolemetsa kwa nthawi yaitali kwa maola 48. Kambiranani zokhudzana ndi vuto lanu ndi dokotala wanu.
Kutetezeka ndi kuthandizira kwa Synvisc mu amayi apakati kapena amayi omwe akuyamwitsa sakhazikitsidwa.
Ngati muli ndi chifuwa cha nthenga, mazira, nkhuku, kapena zinthu zina kuchokera ku mbalame - dziwitsani dokotala wanu.
Kuyerekezera Synvisc ndi Corticosteroid Injections
Synvisc ndi yofanana ndi majekeseni omwe amagwira ntchito mwamsanga koma mwachidule kuposa Synvisc. Jekeseni wobwerezabwereza wa Synvisc amaonedwa kuti ndi otetezeka kuposa corticosteroids kwa odwala okhala ndi comorbidities zomwe zingapangitse corticosteroids kutsutsana. Komanso, dziwani kuti ntchito ya NSAID ikhoza kuchepa kwa odwala ena omwe amatsatira majeremusi a Synvisc.
Zotsatira:
Information Syentc, Sanofi US.
http://products.sanofi.us/synvisc/synvisc.html
Information Patient Synvisc-One. Sanofi US.
http://products.sanofi.us/synviscone/synviscone.html
Hylan GF 20: Onaninso za chitetezo chake ndi zogwira ntchito mu Utsogoleri wa Mavuto Ogwilizana mu Osteoarthritis. Magliore A. et al. Clinical Medical Insights: Matenda a Arthritis Musculoskeletal Disorders. 2010; 3: 55-68.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998981/