Mankhwala atsopano, mementine, omwe tsopano amagwiritsidwa ntchito pochiza matenda a Alzheimer, angasonyezenso malonjezano pochiza matenda a sitiroko. Ngati zikuwonetsedwa kuti zingapindulitse kupweteka kwa sitiroko, ndiye kuti ndi mankhwala oyamba omwe amatha kuchiza mwachindunji.
Matenda omwe alipo tsopano omwe akugwiritsidwa ntchito pambuyo poti sagwidwe samagwira mwachindunji sitiroko yokha.
Udindo wamankhwala wokhalapo chifukwa cha kupweteka kumayang'ana pa zinthu zingapo:
- Kusunga thanzi lachidwi kudzera muzinthu monga madzi ndi ma electrolyte kuti muzitha kuwongolera kupweteka.
- Kuchepetsa mwayi wa kupwetekedwa kwina mwa kupewa magazi opangidwira, nthawi zambiri pogwiritsira ntchito mankhwala ochepetsa magazi.
- Kuzindikiritsa ndi kulamulira zoopsa za poizoni monga matenda oopsa, matenda a mtima, shuga ndi mkulu wa cholesterol.
Kodi Memantine N'chiyani?
Mememine ndi mankhwala atsopano omwe tsopano amagwiritsidwa ntchito pochiza zizindikiro za mitundu ina ya dementia. Dzina lodziwika ndi dzina la Namenda, limadziwika kuti ndi lothandiza kwambiri popewera kukula kwa zizindikiro za mitundu ina ya dementia. Zavomerezedwa ndi United States Chakudya ndi Drug Administration pofuna kuchiza matenda oopsa a Alzheimer, omwe ndi amodzi omwe amachititsa kuti munthu adwale matenda a maganizo.
Kodi Mememine Zimagwira Ntchito Bwanji?
Njira yothandizira mementiyi imakhulupirira kuti imakhala mu chiletso cha mankhwala otchedwa glutamate.
Glutamate yawonetsedwa chifukwa cha kuwonongeka kwa mpweya (ubongo) kupyolera mu mankhwala omwe amatchedwa "neuro excitatory damage". Kuwonongeka kwa maselo a ubongo wa ubongo ndi njira imodzi imene imathandizira kuwonongeka kwa ubongo komwe kumachitika chifukwa cha kupwetekedwa.
Stroke ndizochitika zomwe zimapangitsa kuti ubongo usokonezeke.
Zotsatira za magazi osokonezeka (ischemia) pa ubongo amatchedwa infarction. Infarction amatanthauza kuti minofu ya ubongo imayambitsidwa ndi poizoni ndipo ikhoza kukhala yosavomerezeka, zomwe zimachititsa kuti thupi ndi m'maganizo zilephereke. Motero, kuletsa glutamate kungalepheretse kuwonongeka kwa neurotoxic, kuchepetsa kuwonongeka kwa stroke.
Mankhwala omwe angachepetse malo owonongeka a sitiroko ndithudi adzakhala akugwiritsidwa ntchito poyendetsa sitiroko. Komabe, ngakhale njira yomwe ikuyenera kuchitika iyenera kufufuzidwa bwinobwino kuti iwonetse ngati ili yothandiza.
Pakalipano, kafukufuku amasonyeza kuti kuchepetsa thupi kumachepetsa chigawo cha ubongo wa ubongo ndi kusintha mphamvu za ubongo m'magulu omwe adagwidwa ndi sitiroko, motero n'zotheka kuti iyenso ingagwire ntchito mofananamo kwa anthu.
Kodi Memetine Inagwiritsidwa Ntchito Bwanji Kuthana ndi Sitiroko?
Pakhala pali zochepa zofufuza zomwe zimawoneka zotsatira za memantine mwa anthu. Mwachitsanzo, kafukufuku wina watsopano woposerapo, wopangidwa ndi awiri, wam'nsalu, ku Spain anafufuza opulumuka odwala matenda a stroke 28 omwe anali ndi aphasia Ophunzira omwe analandira chithandizo ndi memantine amasonyeza bwino momwe amalankhulira pamene adachira pamkwapulo awo kuposa omwe sanalandire mankhwala.
Tsogolo la Chikumbutso cha Sitiroko
Nthawi zonse zimakhala zovuta kufotokoza kuti mankhwala adzapangidwe ndi kuvomerezedwa kuti athe kuchipatala. Kawirikawiri, mankhwala atsopano omwe amatsimikizirika kuti ali othandiza ndipo amapezeka kuti alibe zotsatira zoyipa amakhala ndi mwayi waukulu wovomerezeka komanso wogwiritsidwa ntchito. Pakalipano, memantine ikuwoneka kuti ikulonjeza, makamaka chifukwa pali kale deta yomwe ilipo pokhudzana ndi chitetezo pa matenda a Alzheimer's.
Pakalipano, njira zosiyanasiyana zopulumutsira minofu ya ubongo ndizofufuzidwa, monga kupyolera maselo, kusakanikirana ndi magetsi , ndi hypothermia, koma palibe chomwe chatsopano chikugwiritsidwa ntchito.
Memantine imapindula kwambiri pa njira zina izi chifukwa zimapangidwa kale ngati mankhwala, ngakhale ngati mankhwala ena omwe amachititsa kupweteka.
Mawu Ochokera
Stroke ndi imodzi mwa matenda aakulu kwambiri, ndipo pakalipano pali mankhwala ochepa kwambiri okhudza kupwetekedwa. Zambiri zowonjezereka pambuyo pa kupweteka kwa ubongo chifukwa ubongo umachiritsa wokha ndipo chifukwa mapulogalamu monga machiritso ndi kukonzanso thupi amachititsa kuti machiritso apitirize komanso amachititsa kuti munthu wodwala matendawa asokonezeke.
Ngati inu kapena wokondedwa wanu mwadwala stroke, dokotala wanu angakupatseni mankhwala ochiritsidwa kwambiri, kapena kutumizidwa kwa mankhwala omwe asinthidwa kwambiri omwe alipo.
> Zotsatira:
> Memantine imapangitsa kuti maselo apoptosis asamalire pang'onopang'ono pogwiritsa ntchito njira ya calpain-caspase-3 mu njira yoyesera ya sitiroko ya ischemic, Chen B, Wang G, Li W, Liu W, Lin R, Tao J, Jiang M, Chen L, Wang Y, Exp Cell Res. 2017 Feb 15; 351 (2): 163-172. lembani: 10.1016 / j.yexcr.2016.12.028. Epub 2017 Jan 6.
> Kugwirizanitsa ubongo ndi ubongo-kunachititsa kuti mankhwala aphasi asapitirire m'mbuyo mwazirombo: Kufufuza kwa ERP, Barbancho MA, Berthier ML, Navas-Sánchez P, Dávila G, Green-Heredia C, García-Alberca JM, Ruiz-Machimpho R, López-González MV, Dawid-Milner MS, Pulvermüller F, Lara JP, Brain Lang. 2015 Jun-Jul; 145-146: 1-10. lembani: 10.1016 / j.bandl.2015.04.003. Epub 2015 Apr 29.