Pilisi Yogonana ya Flibanserin Imathamangitsidwa mu Drama
Kwa otsutsa ake, flibanserin, mapiritsi a pinki omwe akuwombera akazi libido ndipo opangidwa ndi Sprout Pharmaceuticals, ndi chitsanzo china chokhalira matenda. Matenda okhudzana ndi matenda amatanthauza makampani omwe amagwiritsa ntchito mankhwala ndi ena omwe amachititsa kuti thupi likhale labwino kuti apange bulu. Mwachitsanzo, halitosis kapena mpweya woipa unangokhala mkhalidwe umene ukufunikira chithandizo pambuyo pa Listerine.
Komabe, kwa omuthandizira awo, chilakolako cha kugonana ndi chilakolako cha kugonana ndi matenda enieni, ndipo flibanserin ingathandize. Othandizira awa amatchula mavuto omwe amachititsidwa ndi galimoto yochepa kapena yosagonana.
Kodi Chibwenzi Chogonana / Arousal Matenda N'chiyani?
Chidwi chachikazi / chilakolako chokhudzana ndi kugonana chimatanthauza kuchepetsa kapena kusakhala ndi chilakolako chogonana kwa mkazi amene amatha miyezi 6 kapena yambiri ndipo amachititsa mavuto kapena mavuto. Komanso, kusaganizira koteroko sikungayambitse matenda ena (kuganiza za shuga kapena kupsinjika maganizo) kapena mankhwala osokoneza bongo (taganizirani zolimbitsa thupi). Ndikofunika kuti kutayika kwa chilakolako cha kugonana kumabweretsa mavuto kapena mavuto chifukwa, ngati ayi, sivuta kwenikweni. Ndipotu, anthu ambiri amakhala ndi chidwi chofuna kugonana nthawi zambiri osati chifukwa cha mavuto awo, ndipo izi ndi zabwino.
Ochita kafukufuku amanena kuti chilakolako chogonana ndi chilakolako cha kugonana chimaphatikizapo zovuta za ubongo zoyendetsera mphoto.
Makamaka, chikhalidwe ichi chimakhudza njira za frontostriatal ndi zowoneka bwino za insula, amygdala, hypothalamus ndi ventral striatum. Azimayi omwe ali ndi chidwi chogonana ndi nkhani zotere, zokhuza kugonana ndi zosangalatsa zimakhudza kwambiri. Zindikirani, zopatsa malipiro zopatsa mphotho muzovuta zina zamaganizo kuphatikizapo kuvutika maganizo, schizophrenia, kugwiritsa ntchito mankhwala osokoneza bongo, dementia, matenda odwala ndi zina zovuta zogonana.
N'zochititsa chidwi kuti ofufuza apeza kusintha kwa MRI yomwe imagwira ntchito zomwe zimapangitsa kuti machitidwe olakwika a macrocircuit akukhudzidwa ndi chilakolako cha kugonana / zowutsa. Mwachitsanzo, amayi amapezeka kuti ali ndi matendawa.
Kodi Flibanserin Zimagwira Ntchito Bwanji?
Ndizovuta kwambiri (zosatheka) kuti asayansi afotokoze mitsempha yeniyeni ya ubongo m'madera osiyanasiyana a ubongo. Komabe, pogwiritsa ntchito njira za microdialysis ndi nodes m'magulu a ubongo, ofufuza amati flibanserin imachulukitsa kumasulidwa kwa dopamine ndi norepinephrine komanso kumachepetsa kumasulidwa kwa serotonin kwa amayi omwe ali ndi chidwi chogonana ndi chikhumbo. Mwapadera, flibanserin ikhoza kusiyanitsa pakati pa serotonin receptors ndi kulimbikitsa serotonin 5HT1A receptors pamene itseka serotonin 5HT2A receptors mu prefrontal cortex potero kumatulutsa kutsika kwa dopamine ndi norepinephrine. Zikuoneka kuti zotsatirazi zokhudzana ndi ubongozi zimathandizira bwino kuwonongera mphoto komanso kuonjezera akazi.
Mwachindunji, flibanserin imagwira ntchito pazitsulo zam'madzi, osati mahomoni. Ngakhale mahomoni atsimikiziridwa kuti akuthandizira kuwonjezera libido, zotsatira zake zimawapangitsa kukhala owopsa ngati chithandizo.
Komanso, flibanserin si "Viagra yamkazi." Viagra imagwira ntchito yowonjezera magazi kupita ku ziwalo zogonana pogwiritsa ntchito njira zosiyana komanso kuwonetsa malo osiyanasiyana (ziwalo zokhudzana ndi ubongo ndi ubongo).
Zotsatira zochokera ku mayesero awiri a chipatala otchedwa BEGONIA ndi DAISY (ah, maina a maluwa ... bwanji!) Amasonyeza kuti flibanserin ikhoza kuonjezera chiwerengero cha akazi. Kuphatikizidwa, mayesero awa omwe anagwiritsidwa ntchito mosavuta komanso opangidwa ndi malowa anayezetsa akazi okwana 3548 omwe anali ndi chilakolako chogonana ndi matenda opatsirana. Pambuyo pa milungu 24 yothandizidwa kamodzi ndi tsiku ndi 100 mg flibanserin, zochitika zogonana zokhutiritsa, chilakolako cha kugonana , ndi kuvutika chifukwa cha chilakolako chogonana chinayesedwa pogwiritsa ntchito mayankho osiyanasiyana (omvera).
Ochita kafukufuku adanena kuti anthu omwe amagwiritsa ntchito flibanserin-poyerekeza ndi omwe amatenga malo oterewa amakhala owonjezereka m'maganizo okhudzana ndi kugonana ndi chiwerengero cha chilakolako cha kugonana komanso kuchepetsa kuvutika chifukwa cha chilakolako chogonana.
Zochitika zazikulu zovuta m'mayeserowa zinapezeka pochepera oposa 1 peresenti ya ophunzira, ndipo palibe zochitika zazikuluzikulu zomwe zimayambitsidwa ndi chithandizo cha flibanserin. Zopweteka zochepa zinkakhudzana ndi chizungulire, kunyowa, kutopa, ndi kugona (zomwe zimakhala zofala).
Chiyeso china chosalamuliridwa ndi malo omwe amadziwika kuti SNOWDROP (Ndikuwona chithunzi, apa ... dzina lina la maluwa!), Anafufuza 949 amayi omwe ali ndi chiopsezo chogonana / matenda opatsirana (mwachinsinsi matenda okhudzana ndi kugonana ndi DSM-IV- Tanthauzo limene lakhala likusinthidwa mpaka kugonana / matenda opatsirana mu DSM-5). Mofanana ndi mayesero ena, zotsatira zimasonyeza kuti flibanserin imalimbikitsa chilakolako cha kugonana, zokhutiritsa zogonana zokhutiritsa ndipo zimachepetsa kupsinjika kwa kugonana nthawi zonse pamene zikubweretsa mavuto pang'ono. Mwachindunji, 37.6 peresenti ya amayi pa flibanserin motsutsana ndi 28.0 peresenti ya amayi omwe amatenga placebo adanena zokondweretsa kugonana.
Ngakhale m'mabungwe ena ofufuza anayesera kuphatikizapo anthu omwe amadwala mankhwala opatsirana pogonana, antihypertensives, triptans ndi zina zoterezi, chiwerengero chachikulu cha maphunzirowa ndi kusankhana. M'mawu ena, chifukwa zovuta zokhudzana ndi kugonana ndi chilakolako zikufalikira ndipo zimakhudza mitundu yonse ya amayi, zinali zovuta kuyesa ngati flibanserin imagwira ntchito kwa aliyense.
Pofotokoza za nkhawa ndi chitetezo, a FDA anakana kuvomereza flibanserin kukanidwa kawiri ndi amene wopanga, Sprout Pharmaceuticals, ndi ena akutsutsa. Kuchokera kuchipatala chowona, ndikudzimvera chisoni ndi zomwe FDA akuda nkhawa. Ndipotu, zipangizo za flibanserin zomwe zimakhala ndi mavoti ambiri omwe amagwiritsa ntchito mankhwalawa zimagwiritsanso ntchito mankhwala ena omwe amachititsa kuti ma ARV asokonezeke maganizo.
Kutsiliza
Anthu ambiri moona mtima sadziwa zomwe angaganize za flibanserin. Pachifukwa chimodzi, anthu ambiri amakayikira za makampani opanga mankhwala ndi zolinga zawo ndipo akulosera kuti ngati kuvomerezedwa, flibanserin ikhoza kupitirira malire kwa amayi ena onga awo omwe sakhala ndi nkhawa yokhudzana ndi chilakolako cha kugonana kapena kudzutsa. Pazinthu zowonjezereka, zonse zokhudzana ndi malonda a Flibanserin akulira mobwerezabwereza kuphatikizapo mapiritsi a pinki ndi mapiritsi-minikered matenda. Komabe, n'zovuta kumvetsa zotsatira za flibanserin pokhapokha ngati ndinu mkazi amene amagwiritsa ntchito mankhwalawa.
Zotsatira:
Nkhani yonena kuti "Kuchita bwino ndi chitetezo cha flibanserin m'mayi omwe akutsatira mchitidwe wa kugonana ndi zotsatira za SNOWDROP mayesero" ndi JA Simon ndi olemba mabuku omwe amafalitsidwa mu Kutuluka kwa Mimba: Journal of The North American Menopause Society inafalitsa mu 2013.
Mutu wotchedwa "Njira yogwiritsira ntchito flibanserin, opaleshoni ya serotonin agonist ndi wotsutsa (MSAA), mu vuto lachisokonezo chogonana" ndi SM Stahl lofalitsidwa mu CNS Spectrums mu 2015.
Nkhani yotchedwa "Kupititsa patsogolo chiyembekezo cha matenda okhudzana ndi kugonana (HSDD): chitukuko cha flibanserin" cha J Thorp, Jr, ndi olemba a BJOG omwe afalitsidwa mu 2014.