Chitetezo ndi zomwe muyenera kuyang'anitsitsa pakatenga TB
Tysabri ndi ya anthu omwe ali ndi mawonekedwe obwereza a MS ndipo amathandizidwa ngati kulowetsedwa (kuperekedwa kudzera mu mitsempha yanu) kamodzi pa masiku 28. Zomwe zimaperekedwa kwa odwala omwe sagonjera mankhwala ena ochiza matenda a MS (kutanthauza kuti matenda awo akupitirirabe) kapena omwe sanathe kulekerera ena mankhwala a MS, kaŵirikaŵiri kuchokera ku zotsatira zovulaza kapena zovulaza.
Ngozi ya PML ndi Tysabri
Choopsa kwambiri (koma chosasokonezeka) chotenga Tysabri ndi PML (kupitirira ma multifocal leukoencephalopathy), yomwe ingathe kupha ubongo wa JC. Anthu ali pachiopsezo chachikulu chotenga PML ngati akumwa mankhwala ena omwe amafooketsa chitetezo chawo cha thupi pamene amatenga Tysabri. Zowonjezera zina ziwiri zomwe zimapangitsa kuti munthu akhale ndi mwayi wopanga PML ndi kutenga Tysabri kwa zaka zoposa ziwiri ndikuyesera kuti adziwe kachilombo ka HIV.
Munthu yemwe alibe zifukwa zitatuzi zoopsa zomwe ali nazo ali ndi mwayi wokwana 1 / 50,000 wokhala ndi PML pamene ali pa Tysabri. Koma ngati zifukwa zitatuzi zilipo, chiwopsezo chiri cha 11-13 / 1000. Ngati munthu akungoyesa chithandizo cha JC virus antibody (palibe zoopsa zina) chiopsezo chawo chokhala ndi PML ndi pafupifupi 1/1000.
Pofuna kudziwa kuti munthu ali ndi chiopsezo chotani kuti apange PML, madokotala amayesa kuyesa magazi kuti adziwe kachilombo koyambitsa matenda a JC asanayambe kulemba Tysabri ndi miyezi isanu ndi umodzi pamene munthuyo akutenga Tysabri.
Malingana ndi zotsatira, dokotala adzayang'ana chiwopsezo / chiwopsezo cha kutenga Tysabri ndi wodwalayo. Kuonjezera apo, madokotala adzalandira MRI (kusiyanitsa zizindikiro za mtsogolo za MS kuchokera m'tsogolo zamtsogolo za PML) asanayambe Tysabri.
Kuwunika kwa PML monga Wodwala pa TB
Monga wodwala, ngati mutenga Tysabri, ndizofunika kuti muzitha kukambirana ndi dokotala mwamsanga ngati mutakhala ndi zizindikiro zokhudzana ndi PML.
Izi zikhoza kukhala zovuta ngati zizindikiro zambiri za PML zimatsanzira za MS. Zitsanzo za zizindikiro za PML zikuphatikizapo:
- kufooka pang'ono pambali pa thupi limodzi
- kusokoneza
- masomphenya amasintha
- kusintha kwa umunthu
- mavuto ndi kuganiza, kukumbukira, ndi chikhalidwe chomwe chimabweretsa chisokonezo
Zowonjezera Zowonjezera Zowonjezera ndi Chenjezo la Tysabri
Zotsatira zowonongeka za Tysabri zikuphatikizapo
- kutopa
- mutu
- Matenda a mitsempha kapena kupuma
- vaginitis
- chifuwa kapena kupweteka m'mimba
- kudandaula
- kutsekula m'mimba
- kuthamanga
- ululu wopweteka kapena kupweteka.
Tysabri ikhozanso kuyambitsa kuwonongeka kwa chiwindi, chomwe chingadziwike ndi mayeso a magazi. Zizindikiro za kuvulala kwa chiwindi zimaphatikizapo chikasu cha khungu ndi maso, kutopa kwakukulu, kunyoza, ndi kusanza, kapena mkodzo wakuda.
Tysabri nayenso imayambitsa matenda a herpes a ubongo, chingwe cha msana, ndi manyowa. Zizindikiro za izi zimaphatikizapo malungo, kumutu, kupweteka kwa khosi, mavuto a masomphenya, kusokonezeka, ndi kusintha kwa khalidwe.
Pakhala pali vuto lalikulu loyipa kwa odwala omwe akudwala Tysabri, ena omwe amafunikira chithandizo (ngakhale hospitalization). Zizindikiro za izi zimaphatikizapo ming'oma / kuyabwa, kuzizira, chizungulire, kupweteka pachifuwa, kuthamanga, vuto lopuma komanso kutsika kwa magazi.
Kuonjezera apo , anthu a ku Tysabri akhoza kukhala ndi kachilombo koyambitsa matenda ndipo ayenera kutenga njira zoyenera kuzipewa, kuphatikizapo makhalidwe abwino ochapa manja komanso kupewa anthu odwala, ngati n'kotheka.
Kuwunikira Panthawi ya Tysabri
Tysabri ingaperekedwe kokha ku malo osungirako mankhwala omwe amalembedwa kudzera pulogalamu ya "TOUCH". "KUKHALA" kumayimira "Tysabri Outreach: Kudzipereka Kwodzipereka ku Umoyo" ndipo ndi pulogalamu yomwe inayikidwa pofuna kuyesa milandu iliyonse ya PML kumayambiriro, komanso kuwateteza.
Mimba ya Tysabri
Tysabri amaonedwa kuti ndi "mimba ya chiberekero C," kutanthauza kuti zinavulaza fetusite mu maphunziro a zinyama, koma zotsatira za anthu sizidziwika. Tysabri sayenera kugwiritsidwa ntchito ndi amayi omwe ali ndi mimba ndipo ayenera kuyimitsidwa kwa kanthawi asanayambe kuganiza (kambiranani izi ndi dokotala).
Pansi
Muyenera kugwira ntchito limodzi ndi dokotala wanu kuti mudziwe ngati Tysabri ndi mankhwala abwino kwa inu. Ngati mwasankha kuti mutengepo, onetsetsani kuti mwawerenga mwatsatanetsatane liwu la mankhwala. Komanso, onetsetsani kuti mukukambirana za zizindikiro za PML, matenda, chiwindi cha chiwindi, komanso dokotala wanu. Onetsetsani kuti mukutsatira bwino (mwachitsanzo, patatha miyezi 3 kuchokera kuikidwa mkati), ndipo madokotala ena onse akudziwa kuti mukugwiritsa ntchito Tysabri. A
Zotsatira:
Krumbholz, M., et al. (2007). Kusokonezeka Kwambiri Kwambiri kwa Natalizumab Yogwirizana ndi Kukonzekera Kwambiri Kuthana ndi Matenda Opatsirana. Archives of Neurology , 64: 1331-1333.
Polman, CH, ndi al. (2008). Chiyeso chosalamulirika, chokhala ndi malo omwe amachitidwa ndi natalizumab pobwezeretsanso multiple sclerosis. New England Journal of Medicine , Mar 2; 354 (9): 899-910.
National MS Society. (2016). Mankhwala Osintha Ma MS .
Rudick, RA, et al. (2006). Natalizumab komanso interferon beta-1a pobwezeretsanso matenda ambiri. New England Journal of Medicine , Mar 2; 354 (9): 911-23.
US Food and Drug Administration. Tysabri.
KUDZIZIRANI: Zomwe zili pa tsamba ili ndi zolinga za maphunziro okha. Sitiyenera kugwiritsidwa ntchito ngati choloweza m'malo mwa chisamaliro cha munthu wodwala wovomerezeka. Chonde funsani dokotala wanu kuti apeze matenda ndi chithandizo cha chilichonse chokhudza zizindikiro kapena matenda .