Statin Mankhwala Angayambe Kugwiritsira Ntchito Gene Kukumitsa Ululu Wopweteka
Statins ndi gulu la mankhwala otsika kwa kolesterolini omwe amaletsa kupiritsa mapuloteni ofunika, HMG-CoA reductase, yomwe imayambitsa cholesterol m'chiwindi. Mankhwalawa amathandiza kuchepetsa zikwapu ndi matenda a mtima.
Anthu mamiliyoni ambiri a ku America amatenga zilembo chifukwa amathandiza kwambiri kuti muzitha kumwa mankhwala a LDL ndi mafuta a triglycerides mukamakweza cholesterol cha HDL .
Komabe, monga mankhwala ambiri, pali zotsatira zowopsa.
Zotsatira zoyipa za statins zikuphatikizapo:
- kupweteka kwa minofu monga zotsatira zofala kwambiri
- kuwonjezeka kwa kupanga ma enzyme pachiwindi monga zotsatira zinazake
- kuwonongeka kwa mitsempha ndi chiwindi monga zosavuta kwenikweni
- Matenda a m'mimba, kuphatikizapo gasi, kutsegula m'mimba kapena mseru, monga zotsatira zochepa
- kuwonjezeka kwa shuga m'magazi, komwe kungayambitse kukula kwa mtundu wa shuga wa mtundu wa 2, ndi kowopsa, koma kotheka
- zizindikiro zowonongeka, kuphatikizapo kukumbukira kukumbukira ndi kusokonezeka, ndi chenjezo lochokera ku US Food and Drug Administration lomwe likupezeka pa malemba a statin
Zotsatira Zachikhalidwe za Statins ndi Misampha Yovuta
Pafupifupi oposa 5 mpaka 10 peresenti ya odwala omwe amamwa mankhwalawa amakhala ndi zotsatira zoyipa, zomwe ziri zopambana kuposa malipoti oyambirira. Zizindikiro zingawoneke m'miyezi isanu ndi umodzi yoyamba kapena kuchiwonekera patapita zaka zingapo.
Pankhani ya ululu wa minofu, zotsatira zake zimachokera ku zofooka za minofu mpaka ku rhabdomyolysis yowopsya, yomwe ndi yochepa.
Momwe mungayambitsire minofu mukamatenga zilembo zimadalira zinthu zosiyanasiyana monga:
- kukhala oposa 80, akazi, kapena oonda
- kumwa madzi a mphesa
- kuchepa kwa madzi kapena kumwa mopitirira muyeso mowa
Kafukufuku wofalitsidwa mu nkhani ya 2016 ya New England Medical Journal akuwonetsa kuti maimidwe ovomerezeka a statim-monimmune amachitiranso zotsatira zake.
Minofuyi yowononga mkhalidwe ndi yosawerengeka ndipo imapezeka m'gulu la odwala.
Chifukwa Chake Chifukwa Chachikhalidwe Chakumva Chisoni Chakumva
Kafukufuku wammbuyo amasonyeza kuti jini limathamanga pamayambiriro oyamba a kusokonezeka kwa minofu, yomwe ikukhudzana ndi matenda monga khansa , sepsis , ndi AIDS . Pamene jini la atrogin-1 silikugwira ntchito, kutaya minofu sikuchitika.
Asayansi ku Beth Israel Deaconess Medical Center ku Boston, Massachusetts anawona kuti kuthamangitsidwa-1 kungathandizenso kupititsa patsogolo myopathies mwa omwe amatenga zilembo. Poyesa izi, opendawo anapatsa statin, Mevacor (lovastatin) , kupita ku maselo a minofu, nsomba za zebra, ndi anthu.
Ofufuza anapeza kuti anthu kutenga lovastin anali ndi mapepala apamwamba kwambiri kuposa omwe samamwa mankhwala. Pamene Mevacor yochulukitsidwa yoperekedwa kwa maselo ndi nsomba za zebra, zikanakhala zovuta kuti minofu iwonongeke. Pamene atrogin-1 imachotsedwa m'maselo, mankhwalawa sanawononge minofu.
Zambirizi ndizoyambirira, koma zimatithandiza kumvetsetsa zomwe zingayambitse kupweteka kwa mitsempha mwa ogwiritsa ntchito statin, ndipo chifukwa chake anthu ena amatenga zilembo zingakhale zovuta kuposa izi.
M'tsogolomu, izi zingalole kuti wothandizira zaumoyo wanu adziwone ngati muli pachiopsezo cha myopathies yokhudzana ndi maimfa , kuchokera ku ululu wofewa mpaka ku rhabdomyolysis .
Kuphatikiza apo, asayansi angathe kugwiritsa ntchito jini, kapena ena, kuti athetse kuwonongeka kwa mitsempha yamtunduwu.
Zotsatira:
Hanai JI, Cao P, Tanksale P, ndi al. Minofu yeniyeni yotchedwa ubiquitin imayambitsa atrogin-1 / MAFbx imaphatikizapo mitsempha yowononga minofu. J Clin Invest. 117 (12): 3940-3951.
Mammen, Andrew. New England Medical Journal of Medicine: Statin-Associated Autoimmune Myopathies (2016)
Kliniki ya Mayo: Statin Side Effects - Weight Bene Beneits and Risks (2013)