Kodi matenda a Alzheimer's Infectious? Kodi Ndingachipeze?

Kodi Matenda a Alzheimer Ali ndi Majeremusi Ofanana ndi Omwe Amakhala Odwala?

Dziwani ngati mungathe "kupeza" matenda a Alzheimer kuti musagwiritse ntchito nthawi ndi anthu omwe ali nawo? Dziwani kuti, kugwira dzanja la agogo anu kapena kumukumbatira sikudzakupatsani matenda a Alzheimer's. Sindidzatenga ntchito ngati wothandizira wachikulire ku nyumba yosungirako anthu okalamba ndikugwiritsa ntchito nthawi yodzivala , kusamba ndi kusamalira anthu omwe ali ndi matenda ovutika maganizo .

Fufuzani za momwe Matenda a Alzheimer Akufalikira

Ngakhale kuti matenda a Alzheimer's safalitsidwa kudzera kulankhulana ndi ena, kafukufuku wina ndi makoswe akuwoneka kuti amatha kukhala ndi mtundu wina wothandizira, womwe umagwirizana ndi mapuloteni (mapuloteni omwe maselo a ubongo amayenera kugwira ntchito). Mu matenda a prion , kuphatikizapo matenda a Creutzfeldt-Jakob, mapuloteni a prion amayamba kufalikira mosavuta ndiyeno amachiza tizilombo tomwe timakumana nawo m'thupi, zomwe zimachititsa kuti maselo afe mu ubongo ndi matenda a maganizo. Ngakhale ndalama zopanda phindu zikufalikira mkati mwa munthu, palibe choopsa chilichonse cha matendawa omwe amawakhudza anthu ena, kuphatikizapo mamembala kapena omwe amusamalira.

Kuphunzira ndi Mice

Asayansi anachita kafufuzidwe ndi mbewa, kutenga mbewa zabwino ndikuzijambulira ndi beta amyloid mapuloteni kuchokera ku ubongo wa mbewa zomwe zinapangidwa kuti zikhale ndi matenda a Alzheimer ndi kuwonongera kukumbukira .

Ochita kafukufuku anapeza kuti mbewa zomwe adalandira jekeseni potsiriza zinapanga mapuloteni omwe amamanga mu ubongo wawo komanso kutayika komwe makoswe omwe ali ndi Alzheimer amakhala nawo kale.

Ofufuzawa adayesa kulandira mapuloteni omwe ali ndi kachilombo kudzera m'kamwa, maso, mphuno, komanso intravenously, mu mbewa zabwino ndipo adapeza kuti mbewa sizikhala ndi matenda a Alzheimer's.

Kafukufuku wina wofanana uja anapeza kuti mbewa zabwino zinkakhala zofanana ndi za Alzheimer pamene ubongo wawo unayikidwa ndi tizirombo ta ubongo kuchokera kwa odwala a Alzheimer's.

Kubwereza Kuphunzira ndi Anthu

Phunziro limodzi lokhazikika (phunziro lomwe limafanizira anthu omwe ali ndi vuto linalake kwa iwo omwe sanali) linaphatikizapo kutsata anthu oposa 6,100 omwe kale adayesedwa ndi mahomoni owonjezeka. Ofufuzawa anayezetsa mahomoni awo ndipo anapeza kuti (panthawiyi), anali ndi mapuloteni ochepa omwe amakhalapo mu ubongo wa anthu omwe ali ndi Alzheimer's. Anthu awa akhala akuyang'anitsitsa kuti adziwe ngati ali ndi matenda a Alzheimer's. Pakadali pano, palibe aliyense amene adayambitsa matenda a Alzheimer, ngakhale kuti ambiri adakali achinyamata kuti adziwe kuti ali ndi matenda a 'dementia'.

Kodi Zida Zopanda Zapanga Zingafalikire Matenda a Alzheimer?

Mu imodzi mwa maphunzirowa ndi mbewa zomwe tazitchula pamwambapa, ofufuza anaphimba mapuloteni osakanizika ndi mapuloteni ochepa omwe ali ndi Alzheimer's ndipo amawaika mu ubongo wa mbewa zabwino. Iwo adapeza kuti mbewa izi zinachititsa kuti matenda a Alzheimer apitirire, koma ngati makinawo anali ataphika asanayambe kuikidwa m'malo mwa kukhala opaleshoni yamadzimadzi, njira yabwino kwambiri yozirala.

Ochita kafukufuku anafufuza kuti izi zitheke chifukwa kafukufuku wakale wasonyeza kuti matenda a Creutzfeldt-Jakob , matenda okhudza ubongo omwe nthaŵi zina amatchedwa "nthenda ya ng'ombe yamisala," amatha kufalikira kuchokera kwa wodwala mpaka wotsatira pogwiritsa ntchito zipangizo zopangira opaleshoni, komanso kudzera mwa njira zina.

Kodi Pali Matenda Oopsa a Matenda a Alzheimer's?

Sayansi ikugwira ntchito posankha chomwe chimayambitsa matenda a Alzheimer's. Tikudziwa kuti zifukwa zoopsa monga zaka, majini, mbiri ya banja ndi moyo wawo ndi gawo lonse. N'zotheka kuti malo opatsirana monga opaleshoni angakhale opatsirana mu matenda a Alzheimer, koma izi sizitsimikiziridwa panthawi ino ndipo zimangokhala pa kufufuza koyamba ndi mbewa.

Ngati zikutanthauza kuti ziweto zimathandizira ku matenda a Alzheimer, nkofunika kukumbukira kuti matenda a prion samwazika mwachisawawa kapena kugwirizana kwambiri ndi ena. Choncho, pitirizani kumukumbatira munthu amene ali ndi Alzheimer's. Matenda awo sagwiritsidwa ntchito m'njira iliyonse, ndipo amatha kupeza ubwino wokhudzana ndi kugwira kwa anthu omwe ali ndi chifuwa chachikulu , kuphatikizapo kuchepetsa kuthamanga kwa magazi, kuchepetsa kupweteka komanso kuchepetsa makhalidwe ovuta m'maganizo .

Mawu ochokera

Si zachilendo kukhala wokhudzidwa ndi matenda, makamaka ngati simukudziŵa bwino vutoli kapena chifukwa chake wina akukulitsa. Ngakhale pali zinthu zambiri zomwe sitimamvetsetse za matenda a Alzheimer, tikudziwa motsimikiza kuti kukhala ndi anthu omwe ali ndi Alzheimer, kuwakumbatira kapena kuwasamalira sikungakupangitseni kukhala ndi Alzheimer's.

_Zotsatira:

_{JAMA Neurology. 2013 Apr; 70 (4): 462-8. Kuwonetsetsa kuti matenda a Alzheimer ndi Parkinson amatha kuchepetsa matendawa. http://www.ncbi.nlm.nih.gov/pubmed/23380910}

_{Journal of Neuroscience.15 May 2000, 20 (10): 3606-3611. Umboni Wowonongeka kwa β-Amyloid ndi Intracerebral Kulowetsedwa kwa Alzheimer Brain Extracts mu β-Amyloid Precursor Mapuloteni-Transgenic Manyowa.} > http://www.jneurosci.org/content/20/10/3606

_{Psychiatry ya maselo 17 , 1347-1353 (December 2012) | lembani: 10.1038 / mp.2011.120. De novo induction of deposit amyloid-β mu vivo. https://cen.acs.org/articles/90/i27/Alzheimers-Prion-Connection.html}

_{Proceedings ya National Academy of Sciences ya ku United States of America. August 4, 2009.106 (31). Kuchepetsa ubongo β-amyloidosis: Intracerebral versus systemic Aβ inoculation. http://www.pnas.org/content/106/31/12926.full}