Gonadotropin Kutulutsa Hormone Agonists (GnRH)
Funso: Kodi Gonadotropin Inatulutsa Agonist Agonists (GnRH)?
Yankho: Gonadotropin yomwe imatulutsa agonist (GnRH) ndi mtundu wa mankhwala omwe amalepheretsa ovulation pogwiritsa ntchito estrogen ndi progesterone.
Gonadatropin-Kutulutsa Hormone ndi hormone mwachibadwa m'thupi. Amatulutsidwa ndi hypothalamus ndipo imayambitsa kutulutsa mtundu wa mahomoni otchedwa hormone (FSH) ndi luteinizing hormone (LH).
Mahomoni ameneŵa FSH ndi LH ndiye amachititsa kupanga estrogen ndi progesterone m'mimba mwake. Ubalewu umadziwika kuti ndi hypothalamic pituitary ovarian axis yomwe imayendetsa kusamba kwanu .
Kuti izi zithe kugwira ntchito bwino ndikupangitsa kuti GnRH ikhale ndi chifuwa choyenera kutulutsidwa mwachikondi. Ngati mzerewu ukugwira ntchito bwino, mudzakhala ndi nthawi zonse ngati simudatenga mimba mukamaliza.
Kalasi ya mankhwala omwe amadziwika kuti GnRH agonists imagwiritsa ntchito mpweya wovuta wa GnRH. Mankhwalawa amachititsa kuti phokoso likhale lopitirira. Poyamba pangakhale kufalikira kwafupipafupi kwa FSH ndi LH kumasulidwa komabe GnRH yosagwiritsa ntchito pulsatile imachititsa kuti chiberekero chizisiye kupanga FSH ndi LH, zomwe zimachotsa kutulutsa mahomoni m'thupi.
GnRH atatu agonists omwe amagwiritsidwa ntchito nthawi zamakono ndi awa:
Lupron- leuprolide
Zoladex- goserelin
Synarel- nafarelin
Leuprolide ndi goserelin zimayendetsedwa ndi jekeseni mu mlingo wa milungu iwiri iliyonse kapena masabata 12 pamene nafarelin imayendetsedwa ndi mphuno zakumwa pamadzi 1-2 nthawi tsiku lililonse. Azimayi ambiri amatha kuponderezedwa ndi masabata awiri ndipo pafupifupi amayi onse amatha masabata asanu ndi atatu achiritsidwe.
Chifukwa chakuti GnRH imagwiritsa ntchito kanthawi kochotsa ma ovariza kupanga estrogen ndi progesterone mankhwalawa amagwiritsidwa ntchito kuti athetse mavuto ena mwa amayi omwe ali otetezeka ndi estrogen ndi progesterone. Izi zikuphatikizapo:
Endometriosis
Uterine Fibroids
Kusamalidwa kwa magazi akumirira kwambiri
Matenda a Premenstrual / Premenstrual dysphoria disorder
Chithandizo chopanda chithandizo
Palinso umboni wosonyeza kuti GnRH agonists angathandizenso amayi osungira ovarian opiniki pogwiritsa ntchito chemotherapy pa khansa ya m'mawere.
Mankhwalawa ndi njira zabwino zothandizira mankhwala. Tsoka ilo liri ndi zotsatira zina zofunikira. Chifukwa amachititsa kuti mazira ambiri apange mahomoni, zotsatira za GnRH agonists zimatsanzira zizindikiro za kusamba. Zotsatirapo izi zikuphatikizapo:
Kutentha kwakukulu- kofala kwambiri kumaperekedwa kwa amayi 80%
Vuma lakuya
Kuchepetsa libido
Mutu
Kutopa
Kusokonezeka kwa maganizo
Kuchepetsa kuchepa kwa mfupa
Zikuwoneka kuti zizindikiro za minofu ndi zosasangalatsa koma makamaka zokhudzana ndi zotsatira zake ndi imfa ya minofu yamchere. Kawirikawiri mafupa amatha kusinthidwa pambuyo poti chithandizo chaima koma pang'onopang'ono akaziwa amatha kupulumutsidwa.
Pofuna kupewa kutaya mafupa okhudzana ndi chithandizo cha GnRH dokotala wanu akhoza kulamula progestin kapena kuphatikiza kwa estrogen ndi progestin.
Izi zimadziwika ngati kuwonjezeranso mankhwala ndipo zasonyeza kuti zothandiza kupeŵa kupweteka kwa mafupa ndi kugwiritsidwa ntchito kwa agnist GnRH. Zingathandizenso kuchepetsa kukula kwa kutentha kotentha.
Kusinthidwa ndi Andrea Chisholm MD
Magnon N.Gonadotropin kutulutsa mahomoni agonist: Kukulitsa vistas; Indian Journal Endocrinology Metabolism. 2011 Oct-Dec; 15 (4): 261-267