Cuba imapanga ndudu, ramu ndi ... katemera wa khansa.
Anthu ambiri a ku America akamaganizira za Cuba, amaganiza kuti Fidel ndi odwala, osagwiritsira ntchito ndudu, yummy rum komanso magalimoto a ku America omwe amamanga magalimoto m'ma 1960. Ngakhale zili choncho, Cuba ndi mtsogoleri wadziko lonse lapansi popanga katemera. Zindikirani, katemera amasonyeza chinthu chilichonse chomwe chimapangitsa munthu kuyimirira yekha ngati akuyambitsa matenda a tizilombo kapena tizilombo kapena matenda ena monga khansara.
Kwa zaka 25 zapitazi, ofufuza a ku Citizenic Ebola Institute (Cuba Center for Molecular Immunology) akhala akuphunzira za CIMAvax EGF, katemera womwe umagwira ntchito pa khansara yamapapu yopanda mphamvu yapamwamba (NSCLC). Mwachindunji, katemerayu amachititsa kuti chitetezo cha thupi chiteteze chitetezo cha thupi kuti chiteteze ma antibodies kuti amenyane ndi epidermal-growth factor (EGF), zomwe zimawonjezeka kwambiri mu maselo otupa. CIMAvax EGF yakhala ndi chidwi chochuluka kwa mauthenga ndipo posachedwa ayamba mayesero ochipatala ku United States ali ndi chiyembekezo chakuti katemera akhoza kuteteza khansa yamapapo.
Kuphatikiza pa CIMAvax EGF, akatswiri a ku Cuban amavutikanso kugwira ntchito pa katemera wina wotchedwa Racotumomab-Alum Vaccine (Vaxira) womwe umakonzedwanso kumapeto kwa NSCLC. Ndili mmaganizo, tiyeni tione zomwe tikudziwa zokhudza katemera wotchedwa Racoltumomab-Alum.
Kodi khansara yamapapu yeniyeni (NSCLC) ndi chiyani?
Ku United States, khansa ya m'mapapo imapha amuna ndi akazi ambiri kuposa mtundu uliwonse wa khansa.
(Ndilo vuto lalikulu ku Cuba, nayenso - mbali imodzi chifukwa cha zitsamba zonse za Cuba) NSCLC (mosiyana ndi khansa yaing'ono yamapapo ya m'mapapo) ndiyo khansa yamapapo yamapapo, yomwe imawerengera 75 peresenti ya milandu yonse. Mwatsoka, pafupifupi anthu 70 pa anthu 100 alionse amadziwa kuti ali ndi NSCLC pokhapokha atatha kale matendawa.
Ambiri mwa inu mukudziwa kuti khansa ya m'mapapo imayambitsa chifuwa, mpweya wochepa, kutaya thupi, kufooka komanso imfa. Khansara ya m'mapapo ya mitsempha imatha kufalikira mafupa, chiwindi, ndi ubongo ndipo imayambitsa zizindikiro zina zoopsa.
NSCLC ikagwidwa msanga, opaleshoni ndiyo njira yabwino kwambiri. Komabe, monga tatchulidwira kale, anthu ambiri omwe ali ndi NSCLC amawapeza pamapeto pake ndi mankhwala a chemotherapy kukhala mankhwala abwino kwambiri omwe atsalapo. Ngakhale mankhwala a chemotherapy kapena radiotherapy atsimikizirika kwambiri kuti athandize anthu omwe ali ndi NSCLC. Ndiponso, akatswiri ambiri amakhulupirira kuti mwina takhala tikugunda khoma lamatabwa chifukwa chokhala ndi nthawi yochuluka yowonjezera nthawi yomwe imapangidwa ndi apatini ochizira.
Pogwiritsa ntchito chemo kapena mankhwala a mzere woyamba ku NSCLC mwinamwake amawombedwa, ofufuza achita chidwi kwambiri ndi mankhwala achiwiri. Mwachindunji, ofufuza ayang'ana pa chithandizo chokonza kapena kusintha mankhwala . Thandizo la kusamalira limaphatikizapo kachitidwe kapitirire kachitidwe ka mankhwala oyambirira a mankhwala a chemotherapy mpaka khansara ikutha ndipo ikupita patsogolo. Kusintha mankhwala kumatanthauza kusintha kwa antchito osiyana pambuyo poyambitsa chemotherapy regimen; Munthu woterewa ndi katemera wa racotumomab-alum.
Katemera wa raotumomab-alum kwa khansa ya m'mapapo
Katemera wa khansa ya m'mapapo a racotumomab ndi CIMAvax EGF onse amagwira ntchito yoteteza thupi lawo. Ndi ma immunotherapy, ofufuza amachititsa chitetezo cha mthupi kuteteza khansa ndi matenda ena. Kawirikawiri, matupi athu sagonjetsa maselo a khansa koma akhoza "kunyengerera" kuti achite motero ndi katemera ndi mitundu ina ya imagulu.
Mwachindunji, racotumomab (mu alum adjuvant) ndi anti-monoclonal antibody yomwe imatsanzira antigen ganggenside yomwe ili mu Neuglycolyl (NeuGc), glycolipid yomwe imapezeka mu maselo otupa okha. Motero raotumomab imayambitsa chitetezo cha mthupi pamene thupi limayambitsa maselo a khansa omwe ali ndi Neuglycolyl.
Zina mwazing'ono, Neuglycolyl kawirikawiri amagwira ntchito ngati chithunzithunzi chodziwika bwino chomwe chimachepetsa chitetezo cha mthupi.
Pakalipano, kufufuza pa racotumomab kwakhala kokha ku mayesero ochizira a Phase II ndi Phase III. Ngakhale kuti kulibe mphamvu ndi kuchuluka, zotsatira za mayeserowa zakhala zolimbikitsa. Mufukufuku wina, nthawi ya moyo wapakatikati yapakati yayitali kwa miyezi 8.23 kwa anthu omwe ali ndi NSCLC apamwamba omwe adalandira katemera ngati mankhwala achiwiri. (Chithandizo choyamba ndi chemo.) Ngakhale kuti, mu kafukufuku omwe akupeza malobo (gulu lolamulira), nthawi yamoyo yopitilirapo inali miyezi 6.8. Kuwonjezera pamenepo, kupulumuka kwapanda phindu kunali miyezi 5.33 kwa omwe adalandira katemera motsutsana ndi miyezi 3.90 mu gulu la placebo.
Kuphatikizapo kupereka zopindulitsa zapachilombo, kafukufuku amasonyeza kuti katemera wa racotumomab-alum ndi wotetezeka ndi zotsatira zovuta makamaka kuvutika kwa malo opangira jekeseni kapena kupweteka kwa mafupa. Kuwonjezera apo, katemera ndi wotchipa, ndipo kuyambira 2011, boma la Cuba lakhala likuchiza anthu omwe ali ndi NSCLC osachepera dola dose.
Zoonadi, kutengera khansa ya m'mapapo kwa miyezi ingapo ya moyo wautali kungawoneke ngati kosafunikira. Komabe, tiyenera kukumbukira kuti anthu omwe ali ndi khansara yamapapo ya mapapo, miyezi ingapo ya moyo - makamaka kupulumuka kwapanda pake-angapereke mpata wokhala ndi nthawi yokwanira ndi okondedwa ndikukonzekera zochitika zawo. Kuwonjezera apo, ngakhale kuti kufalikira kwapakati pa nthawiyi kuli pafupi miyezi 8 (kumbukirani kuti pakatikati ndi pakati), anthu ambiri omwe amalandira katemera wa racotumomab-alum amakhala motalika kuposa awa - makamaka anthu omwe ali ndi mayankho amphamvu a anti-IgM ndi IgG.
Nthawi yokha komanso kuphunzira mozama kudzafotokoza mmene racotumomab idzakhalire ndi mankhwala a khansa yamapapo. Mwachitsanzo, sitidziwa ngati chithandizochi chikhoza kugwiritsidwa ntchito kale pochiza matenda m'malo momangika mankhwalawa. Ngakhale molimbikitsanso, kufufuza kwina koyamba kumasonyeza kuti katemera uwu ukhoza kugwiritsidwa ntchito ndi khansa ya m'mapapo yokha koma khansa ya m'mawere ndi khansa ya khansa.
Chifukwa cha kusagwirizana pakati pa dziko la United States ndi Cuba ndikukhalitsa ndi kugwirizana, sititha kuyembekezera kubwereranso kwa malonda komanso kusinthana kwaufulu. Cuba ikupereka luso lodabwitsa la zachipatala, ndipo kafukufuku wamankhwala wakhala akuyang'ana kwa boma la Castro kwa zaka zambiri. Ngakhale kuti mayiko ena sanalowerere mu immunotherapy, Cuba yathandiza kutsogolera munda. Kuganiza, Cuba yapeza zochitika zoterezi mwazing'ono zochepa za bajeti ... bajeti yomwe imapangitsa ndalama za NIH zopindula kwambiri zikuwoneka ngati mphepo yamoto.
Zosankha Zosankhidwa
Mutu wotchedwa "A Randomised, Multimenter, Placebo-Controlled Clinical Trial of Racotumomab-Alum Vaccine monga Kusintha Machinkhwala Therapy m'matenda Achikulire Osakhala Aang'ono Opatsirana Khansa" mwa S Alfonso ndi alembi omwe anafalitsidwa mu Research Research Cancer mu 2014. Kupezeka pa 5 / 22/2015.
Nkhani yotchedwa "Chitetezo ndi Mphamvu za Racotumomab-Alum Vaccine monga Thandizo lachiwiri lachiwiri
Matenda Osakanikirana Aang'ono Osakhala Aang'ono Achipatala "a E. Santiesteban atalembedwa ku International Journal of Clinical Medicine mu 2014. Anapezeka pa 5/22/2015.