Tsogolo Latsopano Mipiringi Yambiri Yodwala
Ngati mukudwala ndi MS kapena muli ndi wokondedwa amene mumamukonda, mwinamwake mumakhala nthawi yochuluka mukuganiza, mukufuna, kapena kupempherera mankhwala abwino, ngakhale mankhwala. Nkhani yabwino ndi yakuti pali mankhwala ochulukirapo ambiri omwe akuphunziridwa pakalipano pakali pano, onse mububu komanso m'mayesero a zachipatala. Chimodzi cholonjeza kuti chithandizo chamtsogolo chidzapangidwe ndi chitukuko cha katemera wa MS.
Kusiyanitsa katemera wa MS kuchokera ku katemera wina
Mukamaganizira za katemera, ambiri a ife timaganiza za kutambasula manja athu kuti tipewe jekeseni yomwe ingatilepheretse kupeza matenda oopsya ambiri, monga chiwindi, chimfine kapena rubella. Katemerawa ali ndi mavairasi kapena mabakiteriya omwe afooka kapena kuphedwa kotero kuti sangatipangitse kuti tiwudwale kwenikweni, koma amanyenga chitetezo chathu cha mthupi kutulutsa yankho.
Koma cholinga cha katemera wa MS sichingakhale chonchi. M'malo mwake, ndi njira yokhayo ikanakhala yothandizira. Izi zikutanthauza kuti zikhoza kuperekedwa kapena kuchepetsa kuopsa kwa zizindikiro zokhudzana ndi MS komanso mavuto a umoyo kwa munthu amene ali kale ndi MS.
Kusiyanitsa kwina pakati pa katemera wamakono ndi wofunsira katemera wa MS ndikuti katemera wamakono wapangidwa kuti ateteze matenda opatsirana - omwe ndi matenda omwe amapezeka chifukwa chokhala ndi tizilombo tina, monga mavairasi kapena mabakiteriya.
Komabe, MS si matenda opatsirana. M'malomwake, MS ndi matenda omwe amadziwika nawo. Pazifukwa zina, chitetezo chathu cha mthupi chikumenyana ndi myelin ndi mitsempha ya mitsempha m'magulu athu amkati . Mwa kuyankhula kwina, MS imayambitsidwa ndi chinachake chimene thupi lathu likuchita kwa ilokha, osati chifukwa cha owononga achilendo.
Choncho, zigawozikulu za ogwira ntchito za katemera wa MS sizilombo toyambitsa matenda koma zinthu zina zomwe zimagwiritsidwa ntchito kuti "tweak" chitetezo chathu cha mthupi chiteteze maselo athu a mthupi kuti asagonjetse ubongo ndi msana.
Kodi MS Vaccines Kukhala Studies Ndi Chiyani?
Pano pali olemba masewera osiyanasiyana osiyana omwe akuyesedwa a MS: Tcelna, NeuroVax, BHT-3009, ndi RTL1000. Katemera uliwonsewu umagwiritsa ntchito njira yosiyana pofuna kukwaniritsa cholinga chake choletsa ntchito yopanga autoimmune motsutsana ndi myelin.
Tcelna (omwe kale anali amphasitiki): Tcelna-yomwe nthawi zambiri imatchedwa Tovaxin-ndiyo katemera wambiri wa T-cell, kutanthauza kuti umakhala ndi maselo a T-cell omwe amagwira ntchito , omwe amawombera myelin mwa anthu omwe ali ndi MS, omwe aphedwa. Mwa kujectza mlingo waukulu wa izi mmbuyo mwa munthuyo, Kuwopsya kumateteza chitetezo cha mthupi kuti chiwononge maselo ena onse omwe akupezeka popanda kukhudza mphamvu zonse za chitetezo cha mthupi.
Katemera uwu wapezeka kuti uli wotetezeka koma sanachepetseretu chiwerengero cha mavenda a MS gadolinium pofufuza odwala 150 m'chaka cha 2008. Tsopano akuyesa kulandira chithandizo chamankhwala atsopano, chomwe chinayambika mu 2012 dzina lake Tcelna, kuti adziwe momwe kuthandizira kuchepetsa ubongo wa ubongo ndi kuchepetsa kulemala.
NeuroVax: NeuroVax ndi katemera wa peptide wa T-cell receptor, kutanthauza kuti umapangidwa kuchokera ku mapuloteni omwe amafanana ndi ziwalo za tizilombo T tomwe timayambitsa myelin. Zapangidwa kuti zithandize thupi kuti lizipanganso zambiri za ma T-maselo omwe amalamulira ntchito za tizilombo ta T, kapena "zoipa".
Neurovax imayikidwa mu minofu milungu iwiri iliyonse. Mayesero amachilendo a Phase 2 opitilira kachilombo kaŵirikaŵiri kafukufuku akuwongolera pakadali katemera.
BHT-3009: Katemerayu ndi opangidwa ndi ma DNA omwe ali ndi mavitamini omwe amafanana ndi mapuloteni a myelin kuti maselo athu amateteza thupi lathu, amatchedwa myelin.
Cholinga chake ndikutulutsa "kusintha" komwe kumayambitsa chitetezo cha mthupi, makamaka "kubwezeretsanso" maselo a chitetezo cha m'thupi omwe amatsutsana ndi chiwalo cha myelin kwa anthu omwe ali ndi MS.
Kafukufuku wa sayansi amasonyeza kuti katemerayu ndi otetezeka komanso amalekerera ndipo angakhale akuyesa masewera olimbitsa thupi m'tsogolomu.
RTL1000: "RTL" ndifupi ndi "miyendo yowonjezera ya T-cell," yomwe ndi mapuloteni omwe amamanga kwa wolandirira T-maselo omwe akuwononga myelin mwa anthu omwe ali ndi MS. Mwa kumangiriza mapepala awa, ma T-maselo sangathe kuwononga. Akatswiri ena samaphatikizapo izi m'gulu la "katemera" pamene ena amachita.
RTL1000 inapezeka kuti ndi yotetezeka komanso yosamalidwa ngati njira imodzi yokha yoperekera chiopsezo m'magulu ang'onoting'ono a Gawo 1. Ochita kafukufuku akukonzekera kuti apite patsogolo kuti ayese chitetezo chake ndi mphamvu zake monga mazunzo angapo pamwezi.
Kupititsa patsogolo Kwambiri M'mabungwe Amitundu Yambiri
Izi zowonjezera katemera zimapereka ambiri a ife chiyembekezo. Inde, iwo adakali kuyesedwa ndipo ali kutali ndi kupezeka kwa ambiri a ife. Komabe, izo ndi zosangalatsa kwambiri. Ganizirani kukambirana nawo ndi dokotala wanu ndikutsatira mayesero pa Chidziwitso cha Clinical Trials Database.
Zotsatira:
Correale J, Farez M, Gilmore W. Katemera wa multiple sclerosis: kupita patsogolo mpaka lero. CNS Mankhwala Osokoneza Bongo. 2008; 22 (3): 175-98.
Correale J & Fiol M. BHT-3009, plasmid yeniyeni yopanga mapuloteni a myelin ochizira matenda osiyanasiyana. Curr Opin Mol Ther . 2009 Aug; 11 (4): 463-70.
Multiple Sclerosis Association of America. (2013). Mankhwala Oyesera: Tcelna (omwe poyamba ankawotchedwa Tovaxin). Adabwezeretsanso January 10th 2015.
Multiple Sclerosis Association of America. (2013). Mankhwala Oyesera: BHT-3009. Adabwezeretsanso January 19th 2015.
Yadav V et al. Recombinant T-Cell Receptor Ligand (RTL) pochiza matenda ambiri: Kugwiritsidwa ntchito kawiri kawiri, kosaoneka bwino, gawo loyamba, kuphunzira kwa msinkhu. Sakanizani Dis . 2012; 2012: 954739.