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Zonse, Tikuwoneni!Amanena kuti simungakhoze kuika mtengo pa thanzi lanu. Pa mapiritsi oposa $ 1000, mankhwala atsopano, Harvoni , amatsimikizira izi.
Pa October 10, 2014, a FDA adavomereza Harvoni yofulumira, mankhwala atsopano okhudzana ndi kachilombo koyambitsa matenda a shuga. Mu 2014, Harvoni ndiye adachiritsira katatu ndi FDA kuti athetse matenda a hepatitis C ndiwotchuka chifukwa cha ntchito yake yodabwitsa kwambiri komanso kamodzi katsiku, kamodzi kake.
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Kodi Hepatitis C N'chiyani?Hepatitis C ndi kachilombo ka RNA kamene kamayambitsa matenda a chiwindi kapena kutentha kwa chiwindi. Pakalipano, chiwindi cha chiwindi cha matenda a chiwindi ndicho chiwopsezo chachikulu cha matenda a chiwindi ku United States ndipo chimakhudza 3 peresenti ya anthu padziko lapansi. Chiwindi cha matenda a chiwindi chimayambitsidwa ndi magazi kapena malonda a magazi, ndipo asanafike poyezetsa kachilombo koyambitsa matendawa, anthu ambiri anadwala pambuyo poika magazi. Pakalipano, anthu ambiri amayamba kutupa chiwindi cha C pambuyo pogawaniza singano pogwiritsa ntchito mankhwala osokoneza bongo.
Hepatitis C ndi tizilombo toyambitsa matenda zomwe sizimayambitsa matenda oopsa kwambiri. M'malo mwake, anthu ambiri amapezeka atapezeka ndi matenda aakulu - pafupifupi zaka 10 mpaka 18 atalandira kachilomboka. Kuwonjezera apo, matenda opatsirana ndi matenda a hepatitis C amachititsa matenda aakulu kwambiri kuposa opitirira 85 peresenti ya anthu omwe ali ndi kachilomboka.
Chiwindi cha chiwindi cha matenda a Hepatitis C chimayambitsa chiyanjano cha hepatocytes kapena maselo a chiwindi. Kuwonjezera pamenepo, kachilomboka kamathamanga mofulumira ndipo motero amagwira ntchito yabwino yoteteza chitetezo cha mthupi. Kutha kwanthawi yaitali kapena kutentha kwakukulu kumadzetsa kufalikira kwa necrosis kapena imfa ya maselo a chiwindi ndi chiwindi. Kuzungulira cirrhosis kumaoneka ngati minofu yambiri yomwe imaphatikizana ndi mavenda a regenerative omwe amachititsa kuti chiwindi chikhale chooneka ngati "lumpy". Pamapeto pake, matenda a chiwindi a C amachititsa kuchepa kwa chiwindi ndi chiwindi. Pomalizira, matenda aakulu a chiwindi cha chiwindi amachititsa kuti pakhale ngozi ya hepatocellular carcinoma kapena khansa ya chiwindi. Zindikirani, mowa, kusuta fodya, kunenepa kwambiri ndi matenda ena omwe ali ndi HIV (kapena ngakhale matenda a hepatitis B) amachititsa kuti matenda a hepatitis C apitirire.
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Kuchiza Musanafike Kubwera kwa Mankhwala Osokoneza Bongo Monga HarvoniChaka chathachi, a FDA akhala akulira ndi kuvomereza mankhwala 3 osiyanasiyana ochizira matenda a chiwindi (C): Harvoni ndi msuweni wake wamakina Olysio (simeprevir) ndi Sovaldi. Komabe, panthawi ina, mankhwala okhawo omwe amapezeka pa kachilombo ka hepatitis C anali pegylated interferon pamodzi ndi Ribavirin. Njirayi, ngakhale ikhale yogwira mtima, imakhala yosagwira ntchito popempha yankho lokhazikika ("mankhwala") kuposa Harvoni ndi azibale ake. Komanso, interferon ndi Ribavirin zimakhala zovuta kulamulira, kutenga nthawi yaitali kuti awononge komanso kukhala ndi mavuto aakulu kuposa mankhwala monga Harvoni.
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Nanga Kodi Haroni N'chiyani?Harvoni ndi gulu la mankhwala omwe amadziwika ngati mankhwala oletsa tizilombo tokha. Mankhwalawa ndi olondola komanso ogwira ntchito popewera kubwereza kwa tizilombo kuposa pegylated interferon ndi Ribavirin. Zindikirani, Harvoni yatsimikiziridwa kuti ili yothandiza kwambiri kwa anthu omwe amatsutsana kwambiri ndi mankhwala a hepatitis C. Komanso, Harvoni imaphatikizidwa ngati mapiritsi a piritsi ndipo ndi yoyamba m'kalasi yake yoperekedwa popanda pegylated interferon ndi Ribavirin. M'mayesero am'chipatala, oposa 90 peresenti ya ophunzira, omwe ali ndi kachilombo ka HIV, omwe analandira Harvoni adalandira ma ARV (mankhwalawo) atatha milungu 12 yokha.
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Kodi Haruni Imakukhudzani Bwanji?Ngati inu kapena munthu amene mumadziwa kuti ali ndi chiwindi cha C, Harvoni ndi mankhwala othandiza kwambiri. Choyamba, kafukufuku amasonyeza kuti mankhwala opatsirana pogonana pofuna kuthetseratu kachilombo ka hepatitis C akhoza kusintha chiwindi cha chiwindi ndi kuteteza kuwonjezeka kwa chiwindi. Chachiwiri, Harvoni, yomwe imabwera palimodzi, imakhala yothandiza komanso yosavuta kutenga kusiyana ndi regimens yomwe imayambira pa pegylated interferon ndi Ribavirin. Chachitatu, Harvoni yatsimikiziridwa kuti ili yothandiza kwambiri kwa anthu omwe sagonjetsedwa ndi matenda a hepatitis C (odwala omwe ali ndi matenda a cirrhosis kapena genotype 1).
Pamapeto pake, mankhwala osokoneza bongo monga Harvoni alandira makina ambiri kuti akhale okwera mtengo kwambiri. Pulogalamu ya masabata 12 ikhoza kuwononga $ 94,500 kapena kuposa mapiritsi a $ 1,000. (Kapena, malingana ndi momwe mukuyang'ana, mtengo wa Mercedes-Benz S550.) Komanso, mapulogalamu ambiri a boma a Medicaid ali ndi nthawi yovuta kuphimba mtengo wa mankhwalawa ndipo amafuna kuti odwala azikhala ndi zovuta zogwiritsira ntchito kuchipatala. landirani chilolezo chisanayambe.
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Pa Chodziwitsa Chamaliza ...Mankhwala osokoneza bongo monga Harvoni akhala akutenga mkombero wokwera mtengo kwambiri. Zoonadi iwo amawononga ndalama zambiri koma thanzi labwino ndi ndalama zapamwamba za moyo wa njira zina - palibe mankhwala othandiza kwa anthu omwe ali ndi matenda a chiwindi a C - omwe amatha kuposa mankhwala zana limodzi. Kukula kwa mankhwala monga Harvoni ndizochitika zenizeni zamankhwala (ndipo sindigwiritsa ntchito mawuwa mopepuka). Mankhwalawa akulonjeza kuthandiza anthu omwe ali ndi matenda opatsirana kwambiri kupeĊµa moyo wautali, ndipo, ndithudi, zovuta zomwe zimachitika m'banja, abwenzi ndi okondedwa.
Zosankha Zosankhidwa
Dienstag JL. Mutu 304. Hepatitis Yachilendo Yovuta. Mu: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. eds. Mfundo za Harrison za Internal Medicine, 18e. New York, NY: Hill ya McGraw; 2012. Yapezeka pa 14 Oktoba 2014.
Dienstag JL. Chaputala 306. Matenda a Hepatitis Osapitirira. Mu: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. eds. Mfundo za Harrison za Internal Medicine, 18e. New York, NY: Hill ya McGraw; 2012. Yapezeka pa 14 Oktoba 2014.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm376449.htm. Yapezeka 10/14/2014.
"Simeprevir pochiza matenda a chiwindi cha hepatitis C" ndi Laure Izquierdo et al kuchokera ku Pharmacogenetics komanso Personal Personalized Medicine anafalitsidwa pa August 14, 2014. Kufikira 10/14/2014
"Kuchepetsa Mankhwala Odwala Matenda a Chiwindi" pogwiritsa ntchito Young Kim et al wa Gut Liver anasindikizidwa mu September 2014. Anapeza 10/14/2014.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164256 /
Ryan KJ, Ray C. Mutu 13. Mavairasi a Hepatitis. Mu: Ryan KJ, Ray C. eds. Sherris Medical Microbiology, 5e. New York, NY: Hill ya McGraw; 2010. Inapezeka pa 14 Oktoba 2014.