Mankhwala Osakaniza Mankhwala Ochepetsa Mankhwala (ADH) kuti achepetse ngozi
Mankhwala ovomerezeka a demopressin (omwe nthawi zina amatchedwa DDAVP) ndi mankhwala omwe amatsanzira mahomoni obadwa mwachibadwa m'thupi ndipo amagwiritsidwa ntchito pochiza enuresis usiku, komanso maulendo ena. Ngati mankhwala amatha kulephera, demopressin ndi mankhwala othandiza kwambiri kuti athandize ana kusiya kuyanika. Kodi demopressin ndi yotani, ikugwira ntchito bwanji, ndipo zotsatira zake ndi zotani?
Ntchito
Mankhwala otchedwa demomopressin amagwiritsidwa ntchito kawirikawiri kuti athetse ana aakazi omwe ali zaka zisanu ndi chimodzi kapena kuposerapo. Mmenemo, choletsedwa cha madzi amadzimadzi chiyenera kutsagana ndi kayendedwe ka mankhwala pa nthawi yogona. Choletsa ichi nthawi zambiri chiyenera kuchoka pa ola limodzi musanayambe kumwa mankhwala mpaka tsiku lotsatira (kapena maola asanu ndi atatu kuchokera pamene mankhwalawa atengedwa).
Desmopressin imagwiritsidwanso ntchito pochita zinthu zina zochepa, kuphatikizapo:
- Matenda a shuga a pakatikati (kupanga mkodzo wosachepera)
- Hemophilia A
- Kuchotsa magazi
- Mtundu 1 wa matenda a Willebrand
Kodi Zimagwira Ntchito Bwanji?
Desmopressin ndi mankhwala omwe amatsanzira timadzi timene timatulutsa thupi lotchedwa antidiuretic hormone . Choncho, amatha kuchepetsa diuresis kapena kupanga mkodzo mu impso zomwe pamapeto pake zimatengera mkodzo.
Kuonjezera apo, demopressin imapanga mankhwala m'magazi otchedwa Factor VIII ndi von Willebrand chinthu, chomwe chili chofunikira kuti asiye kutuluka m'magazi ndikukhala ndi ziphuphu.
Izi zikulongosola maudindo ena omwe sungathe kuthandizira kugwiritsidwa ntchito.
Ndani Sagwiritse Ntchito Desmopressin?
Desmopressin sayenera kugwiritsidwa ntchito pochizira ana omwe ali aang'ono kusiyana ndi zaka zisanu ndi chimodzi. Kuwonjezera apo, mankhwala sayenera kugwiritsidwa ntchito pa nthawi ya matenda yomwe ingakhudze kudya kwa madzi kapena kuchuluka kwa electrolytes (monga kutsekula m'mimba kapena kusanza).
Kuwonjezera pamenepo, anthu omwe ali ndi mavuto a impso, mbiri ya pansi yotchedwa sodium (yotchedwa hyponatremia), kapena ndi von Willibrand matenda a mtundu wa IIB sayenera kugwiritsa ntchito demopressin.
Pali zinthu zina zomwe zimachititsa kuti demmopressin ikhale yogwiritsidwa ntchito mosamala, kuphatikizapo matenda a mitsempha, kuthamanga kwa magazi (hypertension), kuchepa kwa madzi kapena electrolyte, polydipsia (kumwa mopitirira muyeso), cystic fibrosis, kutentha kwa thrombosis, ndi odwala okalamba.
Desmopressin ikhoza kugwirizanitsa ndi mankhwala ena ambiri, kotero mankhwala omwe akuyenera lero akuyenera kuwasamaliranso bwino ndi odwala omwe musanayambe kuwagwiritsa ntchito.
Zotsatira Zogwirizana
Pali mavuto angapo omwe angagwiritsidwe ntchito pogwiritsa ntchito desmopressin. Ngakhale kuti munthu sangayembekezere kukhala ndi zotsatira zambiri - ndipo mwina sangakhale nawo - zina zomwe zimachitika kawirikawiri ndi demopressin ndizo:
- Flushing
- Chills
- Mutu
- Chizungulire
- Kukhumudwa kwa diso (conjunctivitis)
- Kukhumudwitsa kwapadera (rhinitis)
- Nosebleeds (epistaxis)
- Kukuda
- Nausea
- Kupweteka kwa m'mimba
Zochitika Zotheka Kwambiri
Ndi kugwiritsa ntchito mankhwala aliwonse, kuphatikizapo demopressin, pali chiopsezo chachikulu. Izi zimachitika mobwerezabwereza, koma zina zomwe zingachitike ndi kugwiritsa ntchito desmopressin ndizo:
- Low sodium (hyponatremia)
- Kuledzera kwa madzi
- Kugonjetsa
- Anaphylaxis (zoopsa zowonongeka kuphatikizapo kupuma kovuta)
- Kutseka (thrombosis)
Kusamala ndi Kuwunika
Monga tanenera kale, anthu ena ayenera kugwiritsa ntchito demopressin mosamala kapena ayi. Monga momwe mankhwala amagwirira ntchito impso, nkofunika kukhazikitsa ntchito yachibadwa ya impso poyerekeza ndi creatinine m'magazi anu musanayambe kumwa mankhwala.
Ngati mukukumana ndi mavuto aliwonse pogwiritsa ntchito demopressin, muyenera kukhala pafupi kwambiri ndi wothandizira odwala.
Chitsime:
"Desmopressin." Epocrates Rx Pro. Version 3.16, 2011. Epocrates, Inc. San Mateo, California.