Kafukufuku wasonyeza kuti mankhwala ndi ayodine odzola kwa khansa yosiyana kwambiri ya chithokomiro amagwirizanitsa ndi chiopsezo chowonjezeka cha mitundu iwiri ya khansa yamagazi: yovuta myeloid khansa ya m'magazi komanso matenda aakulu a myeloid khansa ya m'magazi.
"Kusiyanasiyana" khansa ya chithokomiro imatanthauzira maonekedwe ndi khalidwe la maselo a khansa, ndipo mu kansa ya kanseri yosiyana kwambiri, maselo amawoneka ndikuchita maselo achibadwa a chithokomiro.
Mitundu ya khansa yodziwika bwino imaphatikizapo chithokomiro cha papillary. carcinoma, follicular thyroid carcinoma, ndi Hürthle cell carcinoma (HCC).
Kawirikawiri amadzimadzi amadzimadzi amachitidwa monga gawo la mankhwala a khansa ya chithokomiro , makamaka pambuyo pa opaleshoni kuchotsa chithokomiro cha chithokomiro. Iodine yothamanga kwambiri, yomwe imadziwikanso ndi RAI, imathandizidwa kuti iwononge minofu iliyonse ya chithokomiro itatsalira pambuyo pa opaleshoni, monga njira yothetsera khansara yowonongeka yomwe ingapangitse kukhalabe ndi matenda a chithokomiro.
Ngakhale kuti kafukufuku wasonyeza kuti opulumutsidwa ndi khansa ya chithokomiro omwe apeza RAI akukumana ndi chiopsezo chowonjezereka cha khansa yambiri yachiwiri , iyi ndi nthawi yoyamba kuti ubale wapadera ndi wowonetsa umapezeka pakati pa iodine ya radioactive ndi khansara ya chithokomiro komanso kuopsa koopsa kwa onse awiri komanso matenda aakulu a myeloid khansa ya m'magazi.
About Myeloid Leukemias
Mankhwala oopsa a myeloid (AML), omwe amatchedwanso kuti myelogenous leukemia, ndi mtundu waukulu wa khansa ya magazi imene ikupita mwamsanga ndipo ikhoza kupha ngati sichikuchiritsidwa.
AML ikhoza kufalikiranso ku ziwalo zina za thupi kuphatikizapo maselo a mitsempha, chiwindi, ntchentche, ubongo, msana, ndi mitsempha. American Cancer Society ikuganiza kuti padzakhala maulendo oposa 21,000 atsopano a AML mu 2017, ndipo anthu pafupifupi 10,600 akufa kuchokera ku AML. AML ndi kawirikawiri asanakwanitse zaka 45, ndipo pafupifupi msinkhu wa wodwala AML ndi 67.
Zaka zisanu zapakati pa moyo wa AML ndi 26 peresenti.
Matenda a myeloid (CML), omwe amadziwika kuti matenda aakulu a khansa ya m'magazi, ndi matenda osapitirira khansa a magazi. American Cancer Society ikuganiza kuti pafupi 9,000 mavoti atsopano a CML adzapezeka mu 2017, ndipo pafupifupi 1,110 akufa. Akuluakulu omwe ali ndi zaka zakubadwa ali ndi zaka 64. Zomwe zimakhalapo kwa zaka zisanu za CML zili pafupi ndi 75 peresenti.
Ofufuzawo adapeza kuti gulu la odwala ladzidzidzi linasintha kansa ya kanseri kuti iwerengere ngozi zawo za khansa yachiwiri ya magazi. Phunziroli, odwala 148,215 omwe ali ndi kansa ya kanseri yosiyana kwambiri anayesedwa. Kwa okwana 53 peresenti ya odwala, chithandizo chawo chokha ndicho chithokomiro, kutsegula kuchotsa chithokomiro. Pafupifupi 47 peresenti anali ndi tizilombo toyambitsa matenda, komanso ma ARV omwe anatsala.
Pakati pa gulu la odwala anaphunzira, odwala 783 anayamba kansa ya magazi yachiwiri pa nthawi yophunzira ya zaka 6.5.
Poyerekeza ndi odwala omwe anali ndi tizilombo toyambitsa matenda okhaokha, odwala omwe anali ndi ayodini oyambitsa mavitaminiwa anali owonjezereka kwambiri kuti angakhale ndi mitsempha yambiri ya myeloid kapena matenda aakulu a m'mitsempha.
Vutoli linali lofanana ngati wodwalayo anali ndi chifuwa chochepa, chokwanira kapena chachikulu.
Pakati pa anthu omwe anadwala khansa ya chithokomiro yomwe inakhazikitsa AML, zaka 2 zomwe zidapulumutsidwa pa TV ndizinanso zochepa kwambiri kuposa anthu omwe ali ndi zaka 2.9 zapakati pa anthu omwe sanakhale ndi mankhwala opatsirana ndi ayodini.
Mawu Ochokera
Kafukufukuyu akuwonetsa kuti odwala omwe asintha kansa ya kanema monga papillary, follicular, kapena kansalu ya khungu ya Hurthle, ndipo amalandira mankhwala othandizira odwala a iodin otsala, akuwonjezeka msanga kuti akhale ndi mitsempha yambiri ya myeloid ndi matenda aakulu a myeloid. Mitsempha yambiri ya m'mitsemphayi imakhalanso ndi vuto loipa kwa odwala pambuyo pa chithandizo cha mankhwala a iodine.
Ofufuzawa amalimbikitsa kuti odwala omwe ali ndi matenda aakulu kwambiri amachiritsidwa ndi ayodini ya radioactive kwa khansa ya kanseri yosiyana kwambiri.
Ngati mutapezeka kuti muli ndi khansara yosiyanitsa bwino kwambiri ndipo dokotala wanu amalimbikitsa chithandizo cha mankhwala a iodine, taganizirani kupeza lingaliro lachiwiri kuchokera kwa dokotala wina.
Ngati mwakhala ndi ayodini wothandizira mavitamini m'mbuyomo, kapena mukhale nawo mtsogolo, onetsetsani kuti nthawi zonse kuyang'anira ndi kuyang'anira ma khansa a magazi ndi gawo la chithandizo chamankhwala. Mukhoza kuyang'aniridwa nthawi zonse ndi mayesero a magazi, komanso ma chromosomal ndi mayesero a majini.
Komanso, yang'anani zizindikiro za mitsempha ya m'mitsempha yambiri komanso yosalekeza, yomwe ingaphatikizepo kutopa, kumverera, kutaya thupi, kuchepa kwa thupi, kuchepa kwachangu, kutentha thupi, kusala kudya, kupuma pang'ono, kutaya thupi, kutuluka kwa usiku, chizungulire, utsi wamagazi, mphuno za nosebleeds, ziphuphu zamphuno
> Chitsime:
> Molenaar, Remco J. et al. "Kuopsa kwa Hematologic Malignancies Patatha Chithandizo cha Radioiodine ya Khansa ya Chithokomiro Yosiyana Kwambiri," Journal of Clinical Oncology, http://ascopubs.org/doi/abs/10.1200/JCO.2017.75.0232?journalCode=jco