Odwala Ayenera Kugwiritsa Ntchito Maganizo Ofunika Powerenga Za IBD Research
Kafufuzidwe pazifukwa zomwe zimayambitsa matenda opatsirana (IBD) ndi zofunika, zofunika, ndi zofunikira. Ndi kafukufuku wamtengo wapatali, asayansi adzatha kudziwa zambiri zomwe zimayambitsa IBD komanso mmene angachiritsidwe. Komabe, palibe pepala lililonse lofufuzira za IBD. Inde, osati pepala lililonse lofufuzira limene likuwoneka kuti likudalira poyamba komanso limadzetsa mpweya wofunikira kwambiri wokhudzana ndi IBD pambuyo pake.
Pali msewu wautali chisanafike chodabwitsa chomwe apeza ndi ofufuza akhoza kukhala chinthu chomwe angachigwiritse ntchito ndi madokotala kuthandiza odwala kapena makampani opanga mankhwala kuti apange mankhwala. Asayansi ena ndi ochita kafukufuku ayenera kufufuza zotsatira zoyambirira ndikukwanitsa kuchita phunziro lina ndikupeza zotsatira zomwezo.
Ochita kafukufuku akuganiza kuti angathe kupeza chinthu chofunikira, amapanga ndikupanga phunziro laling'ono. Ngati phunziroli likusonyeza chinthu chofunika, maphunziro akuluakulu apangidwa. Pakati pa njira, zikhoza kuoneka kuti maphunziro akuluakulu alibe zotsatira zofanana ndi zomwe anaphunzirapo. Pa nthawiyi, kufufuza kwina kumafunika kuti tipeze zomwe zinachitika pakati pa maphunziro awiriwo ndi chifukwa chake sizigwirizana. Kafukufuku sakhala wofunikira monga momwe amaganizira poyamba, ndizokhumudwitsa kwa ofufuza, madokotala, ndi anthu omwe ali ndi IBD.
Chitsanzo cha Kafukufuku Woyamba
Asayansi akhala akudziwa kuti nthawi zambiri anthu omwe ali ndi matenda a Crohn's and ulcerative colitis ali ndi mabakiteriya ndi mapuloteni osiyanasiyana kusiyana ndi anthu omwe alibe IBD.
Kudziwa kuti mapangidwe a zinthu zomwe zili m'matumbo ndi osiyana kwambiri kumapangitsa kuti ochita kafukufuku amvetsetse zomwe akuphunzira.
Ziri zovuta, komabe, kuti mudziwe chomwe chiri ndi mabakiteriya ochulukirapo kapena apuloteni ochepa kapena operewera amatanthawuza mu dongosolo lalikulu la zinthu. Kodi IBD imachititsa kuti kusinthaku kuchitike?
Kapena kodi kusintha kumeneku kumachitika chifukwa china? Kodi kusintha kumeneku kumakhudzana bwanji ndi zomwe zimayambitsa IBD? Pali malingaliro okhudza zomwe zonsezi zingatanthauze, koma sitikudziwabe mayankho a mafunso awa motsimikiza.
Chitsanzo chimodzi chabwino cha kafufuzidwe koyambirira ndi kafukufuku wa 2016 wofalitsidwa mu magazini mBio yomwe idaphunzira za zamoyo m'matumbo a anthu omwe ali ndi matenda a Crohn ndipo amawayerekezera ndi zamoyo za anthu omwe alibe matenda a Crohn. Mabanja omwe anali nawo pa kafukufuku, omwe anali ndi mamembala a IBD ndi omwe analibe mbiri ya IBD, anali kumpoto kwa France ndi Belgium. Zimene asayansi anapeza zinali kuti mabakiteriya awiri, Escherichia coli ndi Serratia marcescens , ndi mitundu ina ya bowa, Candida tropicalis , anapezeka ndi anthu ambiri omwe anali ndi Crohn's disease.
Pamene mabakiteriya ndi bowa anaphunziridwa mu labu, zinapezeka kuti zinagwirizana ndikupanga gulu la maselo omwe amamatira pamodzi, omwe amatchedwa biofilm. Ochita kafukufuku anatenga zojambulazo ndikuchita maphunziro ambiri mu labu, ndipo adasonyeza kuti kutupa m'maselo m'mimba. Phunziroli ndi lofunikira chifukwa linasonyeza kuti pali kusiyana kwa mabakiteriya ndi bowa zomwe zimapezeka mwa anthu omwe ali ndi matenda a Crohn poyerekeza ndi omwe alibe matenda a Crohn.
Anasonyezanso kuti mu kafukufuku wamaphunzirowa, zamoyozi zimagwirira ntchito pamodzi kuti zithyole maselo m'matumbo. Komabe, zotsatira zake zoyambirira sizingatiuze ngati bowa ndi mabakiteriya zimakhudza chitukuko cha matenda a Crohn mwa anthu.
Kotero Tsopano Tidziwa Chimene Chimachititsa Matenda a Crohn?
Ayi, sitikudziwabe chomwe chimayambitsa matenda a Crohn . Zotsatira zatsopano pa mgwirizano pakati pa bowa ndi mabakiteriya ndithudi zimatsegula njira yatsopano yofufuza. Komabe, chinali phunziro laling'ono kwambiri.
Zophatikizapozo zinali mabanja asanu ndi anayi omwe anali ndi mamembala omwe anali ndi matenda a Crohn ndi mabanja anayi omwe analibe mamembala omwe anali ndi Crohn's disease.
Mabanja onse anali ochokera kumadera ena (kumpoto kwa France ndi Belgium). Panali anthu 20 omwe ali ndi Crohn's disease, a m'banja la 28 omwe analibe matenda a Crohn, ndi anthu 21 ochokera m'mabanja omwe analibe mbiri ya matenda a Crohn. Ichi ndi chiwerengero cha anthu 69, omwe sali okwanira kuti apange ndemanga yowonjezereka yomwe ikuphatikizapo anthu onse omwe ali ndi matenda a Crohn padziko lonse lapansi.
Komanso, akuganiza kuti pangakhale kusiyana kwakukulu kwa IBD. Akatswiri a IBD nthawi zambiri amatchula matenda a IBD monga matenda osiyanasiyana. Ngati izi ndizochitika, ndipo zikuwoneka motero, IBD ikhoza kukhala ndi matenda ambiri omwe amadzazana. Pakalipano asayansi ndi madokotala amaika IBD mu zidebe ziwiri, Crohn's disease ndi ulcerative colitis (ndi chidebe chachitatu cha matenda opatsirana omwe amatha kukhala odwala 10 peresenti). Nkhokwe izi zikhoza kukula m'tsogolo pamene tikuphunzira zambiri za IBD. Mukayang'ana pa IBD kuchokera pazifukwa izi, ndithudi padzakhalanso "chifukwa" chimodzi ndi " mankhwala " amodzi. Ngati IBD, monga akatswiri amaganiza, zoposa matenda awiri okha, ndizomveka kuti padzakhalanso majeremusi ambiri komanso zochitika zambiri zowononga zachilengedwe zomwe zimawathandiza kuwapangitsa.
Odwala a IBD ndi ena omwe akutsatira kafukufuku wa zachipatala ayenera kuti anamva mawu akuti "mgwirizano siwongopangika." Izi zikutanthawuza kuti pamene zinthu ziwiri zikuchitika palimodzi, sizinali nthawi zonse kuti mmodzi wa iwo amachititsa wina. Ofufuza anganene kuti bowa ndi mabakiteriya m'matumbo a anthu omwe ali ndi IBD ndi osiyana ndi omwe alibe IBD, koma mgwirizanowu sikutiwuza kuti mabakiteriya kapena bowa amachititsa IBD. Ndikofunika kutsimikizira kuti pali chifukwa chenicheni chokhalira ndi mgwirizano wa zotsatira pakati pa zosiyana ziwiri zisanachitike.
N'chifukwa Chiyani Amalonda Ambiri Amati Tiziwadziwa Chifukwa cha Matenda a Crohn?
Pali zifukwa zingapo zomwe zimapangitsa kuti pepala limodzi lofufuzira likhale ndi chidwi kwambiri. Zovuta zenizeni za intaneti ndizoti zimayendetsedwa ndi magalimoto. Mofananamo nyuzipepala ndi magazini amadalira pazomwe akulembetsa, mawebusayiti amadalira kuchuluka kwa anthu omwe amawona masamba ndi masamba angati omwe akuwona. Mutu wodabwitsa kapena wosokoneza ukhoza kutanthawuza kuti nkhaniyi imagwirizanitsa nawo pazofalitsa komanso imakhala nthawi yochuluka kusiyana ndi imene imagwiritsa ntchito mutu weniweni kapena wokhazikika.
Chinthu chinanso chofotokozera nkhani za kafukufuku ndi kafukufuku wosindikiza mapepala a sayansi. Wolemba yemwe amasindikiza pepala ayenera kutsimikizira kuti mapepala awo amawoneka ndi kuvomerezedwa. Pamene mapepalawa amachokera kumabwalo a maphunziro ndi maphunziro omwe amawerengedwa ndikukambirana, ndibwino. Izi zingathandize ofufuza kapena mabungwe kupeza ndalama zochulukirapo kuti afufuze zambiri.
Kafukufuku wochuluka nthawi zonse ndi chinthu chabwino, koma zotsatira zake n'zakuti pali asayansi aakulu kuti azisamalira kwambiri momwe angathere kuphunzira. Dipatimenti yolumikizana ndi anthu onse pa malo omwe maphunziro achitikapo nthawi zambiri amathandiza kupeza mawu pa phunziro latsopano. Olembawo amatha kulankhulana ndi mauthenga ambiri a mauthenga a mawu. Zonse zimatengera kuti ndemanga imodzi ikhale yosatanthauzira kapena yochotsedweramo, yomwe imabwereranso kuzinthu zambiri zofalitsira ma TV, ndipo pali mphepo yamtundu wachinyengo zomwe sizingathetsedwe.
Chidziwitso Chochokera
Kafukufuku ndi wofunikira kwambiri kwa odwala omwe ali ndi IBD ndi madokotala awo. Kupyolera mu kufufuza kuti mankhwala atsopano amapangidwa ndipo zambiri zimamveka pazifukwa zomwe zingapangitse IBD. Komabe, odwala ayenera kuganiza mozama powerenga za IBD kafukufuku komanso zomwe zikutanthauza.
Pakhala pali kupambana, ndipo padzakhala zambiri, koma mwatsoka palibe chowoneka kuti ndi chimodzimodzi, chifukwa chotsimikizika kapena chithandizo cha matenda monga zovuta monga IBD. Kufufuza kwabwino kudzapitiriza kusuntha chidziwitso chamtsogolo, ndipo ndondomeko yayikulu yapangidwa kale. Sitikukayikitsa kuti padzakhala pepala limodzi la sayansi limene lidzafutukula zinsinsi za IBD, chifukwa chake tiyenera kupitiriza kulimbikitsa kafukufuku wambiri m'madera ndi maboma, mpaka tidziwa zambiri za IBD.
> Zotsatira:
> Crohn's ndi Colitis Foundation ya America. Facebook post. 28 Sept 2016. https://www.facebook.com/ccfafb/posts/1114776048608272
> Hoarau G, Mukherjee PK, Gower-Rousseau C, et al. "Kugwiritsira ntchito mabakiteriya ndi mycobiome kumathandiza kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda. [yofalitsidwa pa Intaneti pa September 20, 2016]. mBio .
> Rehman J. "Kulondola Kwambiri Zamankhwala pa Intaneti." Scientific American. 2 Aug 2012
> Wood, M. "Chifukwa chiyani sitinachiritse matenda opatsirana?" Science Life. 6 March 2015.