Zotsatira Zotsatira, Chenjezo, Ndi Zina Zofunika Kwambiri
Simponi (golimumab) ndi mtundu wa mankhwala wotchedwa bloc TNF-alpha ( tumor necrosis factor alpha ). Zapezeka kuti TNF imathandizira pa chitukuko cha matenda opatsirana (IBD). TNF imapezeka mwa anthu ambiri omwe ali ndi matenda a zilonda zam'mimba ndi matenda a Crohn kusiyana ndi anthu omwe alibe mtundu uliwonse wa IBD.
Mwachidule, monga mankhwala ena omwe amatetezedwa ku chitetezo cha IBD, amamangiriza ku TNF-alpha ndipo amaletsa kugwiritsa ntchito thupi. Mankhwalawa amapangidwa ndi Janssen Biotech.
Ochita kafukufuku amaganiza kuti TNF-alpha imathandizira ku IBD ndi machitidwe a m'mimba. IBD ndi chikhalidwe cha kutupa, ndipo TNF-alpha ndi mankhwala amtundu wotchedwa cytokine . Ma Cytokines samangopereka "mauthenga" pakati pa maselo m'thupi, koma amathandizanso kuti ntchito yotupa ikule.
Kodi Zangotengedwa Bwanji?
Chosavuta chimaperekedwa ngati jekeseni pansi pa khungu. Ataphunzitsidwa ndi katswiri wa zachipatala, odwala angadzipangireko jekeseni yokhayokha kunyumba. Mankhwalawa adzabwera ndi malangizo omveka bwino okhudza ntchito yawo, ndipo dokotalayo adzapereka malangizo ena apadera omwe odwala ayenera kutsatira. Kuyamba Simponi, pali jekeseni 2 kuti uyambe. Kenaka, jekeseni imodzi imapatsidwa masabata awiri kenako.
Ndiyeno, pofuna kusamalira, jekeseni ya Simponi imaperekedwa milungu iwiri iliyonse.
Ntchito
Chosavomerezeka chimavomerezedwa kuti chikhale ndi zilonda zam'mimba zowonongeka m'matenda omwe sanagwiritse ntchito mankhwala ena ochiritsira (sagwiritsidwa ntchito ngati chithandizo choyamba cha mankhwala). Chosavomerezeka chimavomerezedwa kuti chikhale ndi nyamakazi ya nyamakazi , nyamakazi ya psoriatic, ndi ankylosing spondylitis.
Ntchito zosavuta kuteteza kutupa mwa kugwirizana kwa TNF-alpha. Pamene TNF-alpha sichikupezeka chifukwa cha kutupa, IBD ikhoza kulowa nthawi ya kukhululukidwa (pamene matenda ndi zizindikiro zimayambira).
Ndani Asamangoganizira Zambiri?
Uzani dokotala wanu ngati mukudwala matendawa, ngati muli ndi chithandizo cha kachilombo ka hepatitis B, posachedwapa mwalandira chithandizo chokhala ndi moyo, kapena simunayambe mutangokhalira kuthandizidwa ndi Simponi.
Zotsatira Zotsatira
Zowonongeka zomwe zimakhala zosavuta ndi kuphatikizapo matenda opatsirana, kupatsirana kwa jekeseni (monga kufiira kapena kutupa), ndi matenda opatsirana monga matenda a chimfine ndi zilonda zam'mimba . Uzani dokotala ngati zotsatira zake zimakhala zovuta kapena musachoke. Zotsatira izi ziyenera kuuzidwa kwa dokotala wanu nthawi yomweyo.
Machenjezo ena pa zotsatira zoipa
Mankhwala osakaniza ndi ena omwe ali ndi TNF amagwiritsidwa ntchito ndi mitundu ina ya matenda, kuphatikizapo chifuwa chachikulu. Kutsegula kulikonse kwa munthu yemwe ali ndi chifuwa chachikulu ayenera kuuzidwa kwa dokotala yemwe akumuika. Odwala omwe amachiritsidwa ndi Simponi ayenera kuyesedwa kwa chifuwa chachikulu (kuphatikizapo chizoloŵezi choopsa cha matendawa), ndikumalandira chithandizo ngati kuli kofunikira. Pamene akumwa mankhwalawa, odwala ayenera kuyang'ananso ndi zizindikiro za chifuwa chachikulu monga:
- Kupweteka pachifuwa
- Kukuda
- Fever
- Kutaya njala
- Kutuluka kwa usiku
- Kutaya thupi
Mitundu ina ya matenda ndi yotheka, monga mankhwalawa amachepetsera thupi kuti lisakane ndi opatsirana. Odwala omwe apita ku dera lomwe ali ndi matenda akuluakulu a fungalomu kapena omwe ali ndi kachilombo kawunikira kalikonse ayenera kufotokozera izi kwa adotolo omwe akufotokoza mwachidule.
Mankhwala a TNF akhala akugwirizana ndi chitukuko cha mitundu ina ya khansa. Lymphoma wakhala ikufotokozedwa mwa anthu omwe amatenga TNF blockers. Mwachindunji, chiopsezo chotenga hepatosplenic T-cell lymphoma chikuwonjezeka, makamaka mwa anyamata.
Chosavuta chikugwirizana ndi chitukuko cha khansa yapakhungu . Anthu omwe amatenga Simponi ayenera kudziwa kusintha kulikonse khungu lawo, monga kukula kwatsopano kapena timadontho timene timasintha mtundu kapena mawonekedwe.
Anthu amene amanyamula kachilombo ka hepatitis B ali pachiopsezo kuti kachilombo kamene kachiwiri kachiwiri kachilombo kaye kachilombo kaye kamvekedwe ka mankhwalawa. Odwala omwe amagwiritsa ntchito Simponi ayenera kuyesedwa kwa chiwindi cha B chiwindi komanso ayenera kuyang'anitsitsa zizindikiro za hepatitis B monga:
- Chills
- Kusinthasintha kwa m'mimba
- Msuzi wamdima
- Kutopa kwambiri
- Misozi
- Kupanda njala
- Misala ya minofu
- Kuphulika khungu
- Kusokonezeka kwa m'mimba
- Kuthamanga
- Khungu loyera kapena maso
Kuchuluka kwa magazi kwawoneka kwa odwala ena akutsutsa mankhwala osokoneza bongo a TNF. Izi ndizofunikira kwambiri kwa anthu omwe ali ndi IBD, omwe ali pachiopsezo cha maselo ofiira a m'munsi. Dokotala wanu adzayang'ana magazi anu nthawi zonse kuti ayang'ane magazi .
Mavuto ena omwe angakhalepo pamene akutsutsana ndi TNF ndi mankhwala osagwirizana ndi mtima, multiple sclerosis, matenda a Guillain-Barré, matenda a chiwindi, psoriasis, ndi zizindikiro za lupus.
Kuyanjana kwa Zakudya ndi Mankhwala
Chosavuta nthawi zambiri chimagwiridwa ndi mankhwala ena ogwiritsira ntchito IBD monga corticosteroids. Mankhwala omwe angagwirizane ndi Simponi ndi awa:
- Kineret (anakinra)
- Orencia (abatacept)
- Rituxan (rituximab)
- Katemera wamoyo
Palibe zakudya zodziwika zodyera.
Chitetezo Pakati pa Mimba
A FDA adasankha chabe ngati mankhwala B. Zotsatira zake kuti Simponi ali ndi mwana wosabadwa sizinaphunzire mozama. Chokhacho chiyenera kugwiritsidwa ntchito panthawi yomwe ali ndi mimba ngati akufunikira. Adziwitse dokotala ngati mutatenga mimba mukamatenga Simponi. Sitikudziwa ngati Simponi amapita mkaka wa m'mawere, komabe zinthu zina zomwezo zasonyezedwa kuti zilowe mkaka wa m'mawere. Zomwe zingakhale ndi zotsatira zoyipa m'banda ziyenera kuyesedwa pothandizira mankhwala kwa mayi. Njira ina ndikuletsa kuyamwitsa musanagwiritse ntchito Simponi.
Zotsatira:
Janssen Biotech, Inc. "Njira Yowonjezera Mankhwala." May 2013.
Janssen Biotech, Inc. "Simponi Website." May 2013.
Olsen T, Goll R, Cui G, et al. "Minofu ya chifuwa cha necrosis-alpha correlates ndi kalasi ya kutupa m'mimba yopanda zilonda zam'mimba." Scand J Gastroenterol . 2007 Nov 42: 1312-1320.
Roberts-Thomson IC, Fon J, Uylaki W, Cummins AG, Barry S. "Maselo, cytokines ndi kutupa matenda a m'magazi: malingaliro a zachipatala." Katswiri Rev Gastroenterol Hepatol . 2011 Dec; 5: 703-716. lembani: 10.1586 / egh.11.74.