Kodi Mankhwala Akukumana Bwanji Kuti Apeze Matenda a Crohn ndi Ulcerative Colitis?
M'zaka zaposachedwapa, mankhwala ochizira matenda opatsirana (IBD) atcheru kwambiri kuchokera ku makampani opanga mankhwala ndi ofufuza. Tsogolo la anthu omwe ali ndi IBD ndi lowala kwambiri kuposa kale lonse, monga momwe mankhwala ena aliri muipiyo kuti athetse matenda othetsa matendawa ndi mavuto omwe amachitira nawo.
Alicaforsen
Alicaforsen pakali pano ali ndi chilolezo cha Atlantic Pharmaceuticals Limited.
Mankhwalawa amaperekedwa ndi enema ndipo akuyesedwa kuti agwiritsidwe ntchito mu ulcerative colitis ndi pouchitis . Alicaforsen wapatsidwa mwayi wosamalira ana amasiye ku United States ndi European Union.
Alequel
Enzo Biochem yatha kuphunzira Alequel kwa odwala omwe ali ndi matenda aakulu a Crohn. Mankhwalawa ndi machiritso omwe ali ndi mapuloteni omwe amapangidwa kuchokera ku minofu kuchokera kumtundu wa wodwalayo ndipo amaperekedwa pamlomo. Chikhululukirocho chinakwaniritsidwa ndi 50 peresenti ya odwala pa mankhwalawa, peresenti 33 peresenti yokhala ndi placebo. Mankhwalawa analoledwa bwino, popanda zotsatirapo zoipa.
Teduglutide
Gulu latsopanoli likuphunziridwa kuti ligwiritsidwe ntchito zonse ziwiri za IBD ndi matenda afupipafupi (SBS) . SBS ndi vuto lomwe limayambitsa kutsegula m'mimba, kupunduka, kupweteka, ndi kupweteketsa mtima kumene kumachitika mwa anthu omwe ali ndi theka (kapena kuposa) m'matumbo awo aang'ono omwe achotsedwa. Chinthu chofala kwambiri cha SBS chimagwiritsidwa ntchito mobwerezabwereza opaleshoni yogwiritsidwa ntchito pofuna kuchiza matenda a Crohn.
Zotsatira za teduglutide zimawoneka ngati zochepa, chifukwa zotsatira zake zimapezeka makamaka m'matumbo. Anthu omwe ali ndi SBS omwe adayesedwa mu mayesero a teduglutide adasonyezeranso kuwonjezeka kwa zakudya ndi thupi. Kawirikawiri lipoti loipa limakhudza kupweteka kwa m'mimba, mutu, kusintha kwa mimba, ndi kutupa.
NPS Mankhwala, katswiri wa teduglutide, anamaliza maphunziro a umboni wa odwala omwe ali ndi matenda a Crohn. Pa odwala omwe ali ndi Crohn's, 55 peresenti anali atapindula pakapita masabata asanu ndi atatu akugwiritsa ntchito mankhwalawa, poyerekeza ndi 33 peresenti ya odwala omwe ali ndi malowa. Nkhani yowonongeka kwambiri inali yofiira pamalo a jekeseni. Phunziro lina likuchitika pa odwala omwe ali ndi SBS.
Teduglutide yathandizidwa ndi mankhwala osamalira ana amasiye ku United States ndi Europe chifukwa cha ntchito yake ku SBS. NPS ikuyang'ana bwenzi lomanga chitukuko kuti apitirize kuyesa mankhwala kuti agwiritsidwe ntchito mu matenda a Crohn.
Traficet-EN (CCX282)
Traficet-EN ndi anti-inflammatory small molecule mankhwala omwe panopa akuyesedwa kuti agwiritsidwe ntchito mu matenda a Crohn ndi wopanga, ChemoCentryx. Mu kuyesedwa kwaposachedwa (PROTECT-1), kuchulukitsa kwa odwala omwe akulandira mankhwala akukhululukidwa pambuyo pa masabata 36 kuposa omwe adalandira placebo. Mankhwalawa analoledwa bwino pakati pa ophunzira pa phunziro la miyezi 12.
Zotsatira:
ChemoCentryx. "CCR9 Program.". 2010. June 26, 2010.
Enzo Biochem, Inc. "Alequel." . 2010. June 26, 2010.
Isis Pharmaceuticals, Inc. "Matenda Opweteka." . 2010. June 26, 2010.
Margalit M, Israeli E, Shibolet O, Zigmond E, Klein A, Hemed N, Donegan JJ, Rabbani E, Goldin E, Ilan Y. "Kachilombo kawiri khungu kochiritsira matenda a Crohn ndi matenda a Alequel, osakaniza ya mapulotini otchedwa autologous-proteins: njira yoyendera matenda. " Am J Gastroenterol March 2006 101: 561-568. 26 June 2010.
NPS Mankhwala. "Misonkhano Yothandizira NPS." 2010. 26 Feb 2012.