Mayeso a LDH angathandize dokotala kudziwa ngati khansara lanu la khungu lafalikira
LDH ndi mayeso a magazi omwe amayesa kuchuluka kwa lactate dehydrogenase (LDH), ndi enzyme, m'magazi anu. Mankhwala, LDH amagwira ntchito kuti asinthe pyruvate ndi lactate m'thupi lanu. Mwinamwake mumadziwa bwino lactate, chifukwa ndi zomwe zimachitika m'thupi mwathu mutatha kuchita masewera olimbitsa thupi ndipo zimakupweteketsani.
Mwachidule
Kawirikawiri, LDH imayesedwa kuti iwononge kuwonongeka kwa minofu m'madera monga mtima, chiwindi, impso, mitsempha, ubongo, ndi mapapo - onse omwe, ngati avulala, akweze mlingo wa LDH m'magazi anu.
Ngati muli ndi khansa ya khansa , dokotala wanu angathe kugwiritsa ntchito mayesowa kuti athandizidwe kudziwa ngati khansara yanu yayamba kapena imafalikira ku ziwalo zoposa khungu lanu ndi maselo a mitsempha . Malo ambiri omwe khansa yapita patsogolo ndi chiwindi kapena mapapo. Ngakhale kuti LDH sichidziŵika bwino ndi khansa ya khansa, ingakhale yothandiza kwambiri kuti mupeze chithandizo cha khansa ya khungu pambuyo pa opaleshoni. Mankhwala a khansa ya khansa imagwiritsanso ntchito zotsatira za kuyesa kwa LDH kuti athe kugawaniza odwala omwe ali ndi stage IV matenda.
Mmene Testedwe Imapangidwira
Kuti mudziwe mayendedwe anu a LDH, wothandizira zaumoyo wanu adzalandira magazi kuchokera mu mitsempha yanu kapena ku chidendene, chala, chala, kapena earlobe. Labatore imatha msanga magazi kuti apatule seramu, gawo lamadzi la magazi anu, kuchokera ku maselo a magazi. Mayeso a LDH amachitidwa pa seramu ya magazi.
Musanayambe kuthamanga magazi, dokotala wanu angakufunseni kuti musiye kumwa mankhwala ena omwe amadziwika kuti azikhudza LDH.
Mankhwala omwe angathe kuwonjezera LDH ndi monga mowa, anesthetics, aspirin, kutsekemera, fluorides, mithramycin, mankhwala osokoneza bongo, ndi procainamide. Ascorbic acid, kapena vitamini C monga momwe amadziwikiratu, akhoza kuchepetsa LDH yanu.
Kodi Zotsatira Zoyesero Zimatanthauza Chiyani?
Miyezo yachibadwa imasiyana malinga ndi msinkhu wanu, kugonana, ndi njira yeniyeni yogwiritsidwa ntchito mu labotale.
Mndandanda wa zolembera zambiri ndi 105 mpaka 333 IU / L (mayiko apadziko lonse pa lita). LDH yonse imakhala yosiyana kwambiri ndi zigawo zisanu (zomwe zimatchedwa isoenzymes) - LDH-1, LDH-2, LDH-3, LDH-4, ndi LDH-5 - zomwe zimadziwika kumadera ena a thupi ndipo zimawonetsedwa ngati magawo mwa chiwerengerocho.
Mlingo wa LDH ukhoza kukwezedwa muzinthu zambiri, osati kungokhala melanoma ya metastatic. Mapangidwe apamwamba kuposa amodzi angasonyezenso:
- kupwetekedwa
- matenda amtima
- matenda ochepetsa magazi osiyanasiyana
- kuthamanga kwa magazi
- matenda a chiwindi (mwachitsanzo, matenda a chiwindi)
- kuvulaza minofu
- kupweteka kwa thupi
- chifuwa chachikulu
Zotsatira zabodza zabodza zikhoza kuchitika ngati zitsanzo za magazi zinkasamalidwa bwino, zosungidwa kutentha kwambiri, kapena ngati nyembazo zinali zovuta kusonkhanitsa.
Zimene Amafufuza
Maphunziro oyambirira asonyeza kuti mlingo wokwezeka wa LDH ukhoza kufotokoza kupulumuka kwa odwala okhala ndi melanoma yapamwamba. Pachifukwa ichi, LDH inaphatikizidwa mu dongosolo la 2002 la khansa ya khansa. Odwala omwe ali ndi matenda a khansa yotchedwa sepirinic IV ndi a LDH okwera kwambiri ali ndi vuto loipa kwambiri.
Kuwonjezera pa kugawa odwala omwe ali ndi gawo lachilombo cha IV, mayeso a LDH sali otsimikizika kapena omveka bwino kuti azindikire khansa ya khansa isanayambe kugwiritsidwa ntchito kwa maselo am'mimba. Kafukufuku wina adatsatira odwala khansa ya khansa ya khansa ya khansa kwa zaka 2.5 pambuyo pochita opaleshoni.
Zotsatirazo zinawonetsa kuti mlingo wa LDH sunali chizindikiro chabwino pa "masentimita" (gawo la IIIC melanoma lomwe lafalikira kupyola khungu la khungu koma osati ku maselo a mitsempha) kapena kufalikira ku maselo am'deralo. Mu phunziroli, mayeso a LDH adangogwiritsira ntchito molondola mthupi mwa odwala ochepa. Chiyeso cha mapuloteni ena omwe amatchedwa S-100B akuwonekera ngati chizindikiro choposa LDH ndipo chikhoza kuikidwa m'zinthu zam'tsogolo.
Ngati dokotala wanu wapereka mayeso kwa LDH, kapena ngakhale zotsatira zitabwerera ndipo msinkhu uli pamwamba, musawope. Mphamvu ya LDH sizitanthauza kuti khansa yanu ya melanoma yatha, ndi "mutu wa pamwamba" kuti dokotala azifufuza zomwe zikuchitika ndi CT, PET, kapena MRI scan kapena sentinel lymph node biopsy.
Ngati muli ndi mafunso kapena zodandaula za kutanthauzira zotsatira zanu za kuyesedwa kwa LDH, onetsetsani kuti mukukambirana nawo ndi dokotala wanu.
> Zotsatira:
> Egberts F, Hitschler WN, Weichenthal M, Hauschild A. "Kuwonetsetsa kwa mankhwala a adjuvant pa odwala kwambiri a khansa ya khansa: lactate dehydrogenase ndi mapuloteni S-100B monga zizindikiro zowonongeka" Melanoma Research 2008.
> Chun YS, Wang Y, Wang DY, et al. "Kukula kwa mayeza a S100B ndi ma LDH pa odwala matenda a melanoma" J Clin Oncol 2008 26 (May 20 suppl; Abstr 9002).
> Ammermontont AMM. "Reaching First Base mu Chithandizo cha Melanoma ya Metastatic" J Clin Oncol 2006 24 (29): 4738-45.