Kuzindikira zizindikiro za PML vs.
Mapulogalamu apamwamba a leukoencephalopathy (PML), ndi osowa koma nthawi zambiri amafa chifukwa cha matenda a JC . Matendawa amatetezedwa ndi chitetezo chanu cha mthupi kotero kuti sichikhoza kuwononga.
Komabe, ngati chitetezo cha m'thupi chanu chikufooka ndi matenda, monga HIV / Edzi , khansa ya m'magazi , lymphoma, kapena khansara ina, kapena ngati mankhwalawa amachiza mankhwala, kachilomboka kangayambitse ubongo wanu.
Kuwonongeka kwa ubongo chifukwa cha PML kungachititse zizindikiro zosiyanasiyana.
Ngakhale kuti PML ndi yochuluka kwambiri, ndimadandaula kwambiri ngati muli ndi multiple sclerosis (MS) chifukwa mankhwala ena omwe amagwiritsidwa ntchito pochizira matendawa amachititsa kuti pakhale mwayi wopeza PML.
Tysabri (natalizumab) ikuwoneka kuti ikukhudzana ndi ngozi yaikulu ya PML. Komabe, mankhwala ena omwe amagwiritsidwa ntchito ndi immunosuppressive angathe kuika pangozi, kuphatikizapo Gilenya (fingolimod), Tecfidera (dimethyl fumarate), Ocrevus (ocrelizumab), komanso ena.
Zizindikiro za PML
MS mwiniwake saonjezera chiopsezo cha PML. Koma ngati inu kapena wokondedwa wanu mukudwala mankhwala omwe amachititsa kuti chitetezo cha mthupi chitetezedwe, kudzidziwitsa nokha ndi zizindikiro za PML kumakupatsani mwayi wogwira ntchitoyi ndikudziwitsidwa kuti mutha kuwona zotsatirazi.
Monga zizindikiro za MS, omwe amagwirizanitsidwa ndi PML amasiyana, malingana ndi malo kapena ubongo.
Zizindikiro zingakhalepo:
- Zofooka, nthawi zambiri kumbali imodzi ya thupi
- Kulephera kuganiza bwino, komwe kumakhala kusokonezeka komanso / kapena kukumbukira kukumbukira
- Kuvuta kulankhula
- Kusamalidwa kolakwika, kawirikawiri kumakhala kusokonezeka kapena kuyenda movutikira
- Mavuto akuwonetseratu, monga masomphenya osasamala kapena osayang'ana bwino pa malo enieni a masomphenya anu
- Kusintha kwa umunthu
- Kusamva bwino kapena kutayika kwa thupi lanu m'thupi lanu
- Kugonjetsedwa, ngakhale kuti izi si zachilendo
PML vs. MS Kubwerera
Zizindikiro za PML nthawi zambiri zimasiyanitsidwa ndi zomwe zimachitika kuti MS abwererenso. Izi sizosadabwitsa chifukwa matenda onsewa amachititsa kuti thupi liwonongeke, kutanthauza chiwonongeko cha zinthu zoteteza zomwe zimayambitsa mitsempha. Kutaya chitetezo ichi, chotchedwa myelin, chimasokoneza kutumiza kwa zizindikiro zamagetsi pakati pa ubongo ndi thupi lanu.
Chifukwa chakuti zizindikiro za PML ndi kubwezeretsa kachilombo ka MS zingakhale chimodzimodzi, zimakhala zovuta kuzindikira PML kumayambiriro kwa matendawa. Izi zinati, liwiro la chitukuko cha zizindikiro zatsopano ndi chitsimikizo chomwe chimathandiza kusiyanitsa ngati ali chifukwa cha PML kapena MS kachiwiri. Zizindikiro za PML sizichitika modzidzimutsa koma makamaka zimakhala ndikupita patsogolo masiku ambiri mpaka masabata.
Madokotala akhoza kutanthauzira momveka bwino kusiyana kwa PML kuchokera ku MS pofufuza mosamala za zizindikiro za munthu. Chifukwa chakuti PML ndi matenda ambiri a ubongo, nthawi zambiri zimayambitsa zizindikiro zatsopano kapena zowonjezereka, pamene chizindikiro chimodzi chokha chimakhala ndi kubwezeretsedwa kwa MS. Komabe, ichi ndi chinsinsi chabe, osati lamulo lovuta.
Njira yina yosiyanitsira PML kuchokera ku MS wobwereza ndi kuyesa njira ya MRI ya ubongo wa munthuyo.
Monga MS, PML imayambitsa zilonda za ubongo ku MRI, koma zimakhala zosiyana ndi zilonda zamtundu wa MS mu kukula, mawonekedwe, malo, ndi zina.
Pampopu yamaginja kuti ayesetse khungu lamtundu wa kachilombo ka JC imagwiritsidwanso ntchito kutsimikizira kuti matendawa ali ndi PML. Pomalizira pake, ubongo umagwiritsidwa ntchito nthawi zina.
Mawu Ochokera
Ife tikudziwa kuti ngakhale kuthekera kwina kulikonse kokhala ndi PML ndizofunikira kwambiri pamene mukudwala mankhwala ena ochepetsa matenda a MS. Ngati muli pa Tysabri, Gilenya, Tecfidera, Ocrevus, kapena mankhwala ena osamalidwa ndi immunosuppressant kwa MS ndipo onani zowonongeka kapena zowonjezereka, funsani dokotala mwamsanga.
Ngakhale kuti zizindikirozi sizimasonyeza nthawi zonse chitukuko cha PML, kuyesa kuchipatala n'kofunika chifukwa vutoli limakhala loopsa kwambiri. Kuyezetsa magazi msanga kukupatsani mpata wabwino wa zotsatira zabwino mukakhala ndi PML.
> Zotsatira:
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> Greenlee JE. Progressive Multifocal Leukoencephalopathy (PML). Mu: Porter RS, Kaplan JL, Lynn RB, et al. Merck Manual Professional Version .
> Maas RPPWM, Muller-Hansma AHG, Esselink RAJ, et al. Kugwirizana kwa Mankhwala Osagwiritsidwa Ntchito Mankhwala Otsitsirako Mankhwala Opanga Mankhwalawa: A Clinical, Radiological, ndi Cerebrospinal Fluid Analysis of 326 Cases. J Neurol . 2016; 263 (10): 2004-2021.
> Bungwe la National for Disturbances Rare. (2015). Progressive Multifocal Leukoencephalopathy.
> Wollebo HS, MK Woyera, Gordon J, Berger JR, Khalili K. Kulimbikira ndi Pathogenesis a Neurotropic Polyomavirus JC. Ann Neurol . 2015 Apr; 77 (4): 560-570.