Uloric (febuxostat) inavomerezedwa ndi US FDA pa February 13, 2009. Uloric ndiyo njira yoyamba yothandizira pakadutsa zaka 40 kwa odwala omwe ali ndi hyperuricemia ndi gout, malinga ndi Takeda Pharmaceuticals North America, Inc.
Uloric ndi mankhwala omwe amagwiritsidwa ntchito kuti azisamalira bwino matenda a hyperuricemia mu gout. Uloric imachepetsanso mphamvu ya serum uric acid poletsa xanthine oxidase-enyzme yomwe imayambitsa uric acid kupanga.
Xanthine oxidase imathyola hypoxanthine (chilengedwe chochokera ku purine) ku xanthine, ndiyeno ku uric acid.
Kodi Uloric Imayendetsedwa Bwanji?
Mlingo woyenera wa Uloric ndi 40 mg ndi 80 mg kuperekedwa kamodzi pa tsiku. Uloric ndi mankhwala amlomo (otengedwa pakamwa). Mlingo woyambirira wa Uloric ndi 40 mg kamodzi tsiku lililonse. Kuwonjezeka kwa 80 mg akulimbikitsidwa kwa odwala omwe samapindula ndi seramu uric acid osachepera 6 mg / dL patatha milungu iwiri pa mlingo wa 40 mg. Uloric ukhoza kutengedwa kapena wopanda chakudya ndipo palibe malangizo omwe amaletsa kugwiritsa ntchito antacids. Palibe kusintha kwa mlingo komwe kumafunikira kwa odwala omwe ali ndi vuto lopweteka kapena lopanda mphamvu.
Kuchita Muzochitika Zoyesedwa
M'mayesero am'chipatala, Uloric yapamwamba imapezeka kuti ikugwira ntchito kwambiri kuposa placebo kapena mlingo wa mlingo allopurinol - mankhwala ena ochizira matenda a hyperuricemia. Komanso, pamayesero amodzi a miyezi isanu ndi umodzi (3) omwe ali ndi matenda a gout, amene adachepetsa ma oric acid m'magulu ochepa pansi pa 6, anali apamwamba kwambiri kwa iwo omwe amatenga 80 mg kuposa omwe amatenga 40 mg Uloric.
Zotsatira zoyipa ndi machenjezo
Uloric sivomerezedwa kwa anthu omwe ali ndi matenda osokoneza bongo. Mankhwalawa sayenera kugwiritsidwa ntchito ndi anthu omwe akuchitidwa kale ndi azathioprine (Imuran), mercaptopurine, ndi theophylline.
Pogwiritsa ntchito maphunziro atatu omwe amachitidwa bwino, odwala matenda a chiwindi , nthenda, arthralgia, ndi mphutsi ndizo zotsatira zovuta kwambiri zomwe zimachitika pafupifupi oposa 1% mwa odwala ndi Uloric ndipo osachepera 0,5% kuposa a placebo.
Komanso, poyerekeza ndi allopurinol, Uloric imagwirizanitsidwa ndi mlingo wapamwamba wa zochitika za mtima, koma palibe chidziwitso chodziwika bwino chodziwika bwino. Chiwindi ntchito sizinali zachizoloŵezi zomwe zimawopsya kwambiri zomwe zimayambitsa kusuntha kwa Uloric.
Pakhala pali mauthenga apambuyo olepheretsa odwala, omwe amawapha komanso osafa, odwala omwe amachitidwa ndi Uloric. Lipotilo silinali ndi deta yokwanira kuti zikhazikitse zifukwa zomveka.
Kuwonjezeka kwa gout flares kawirikawiri kumakhalapo pamene anti-hyperuricemic agents ayamba. Izi zikuphatikizapo Uloric. Ngati mankhwala amtunduwu amayamba chifukwa cha mankhwalawa, mankhwalawa sayenera kuthetsedwa. Pofuna kupewa kutsekemera kwa gout komwe kumayambitsidwa ndi kulandira mankhwala a Uloric, NSAID kapena colchicin ingatengedwe nthawi yomweyo. Kuwonjezereka kwa gout flares kwatchulidwa kuti kuchepetsa mphamvu za seramu uric acid zomwe zimayambitsa kusuntha kwa minofu.
Panalibe maphunziro oletsa bwino a Uloric azimayi oyembekezera. Pakati pa mimba, Uloric iyenera kugwiritsidwa ntchito pokhapokha phindu limene likuyembekezerapo likupitirira kuopsa kwa mwanayo. Ndiponso, sikudziwika ngati Uloric imatulutsidwa mu mkaka waumunthu.
Akazi achikulire ayenera kukhala osamala.
Kutetezeka ndi kupambana kwa Uloric kwa ana osakwana zaka 18 sadziwika.
Zotsatira:
Kufotokozera Uloric Information. Uloric.com. Takeda Pharmaceuticals Inc. Yosinthidwa March 2013.
FDA imavomereza ULORIC® (febuxostat) ya Chronic Management of Hyperuricemia kwa Odwala ndi Gout. Takeda Pharmaceuticals. February 13, 2009.