Kugwiritsira ntchito kolchicine mosatetezeka kumachepetsa zotsatira zosafunika
Colchicine ndi chithandizo chovomerezeka cha gouty arthritis. Ngakhale mankhwalawa ndiwopindulitsa kwambiri pa chithandizo cha mankhwala a gout , pali zambiri zomwe sizikudziwika bwino za colchicine. Mwachitsanzo, momwe colchicine ikugwirira ntchito, kuchokera kumene imachokera, yakhala ndi chithandizo chamankhwala kwa nthawi yaitali bwanji, ndipo chofunikira kwambiri, chomwe muyenera kudziwa kuti mugwiritse ntchito mankhwala mosamala.
Mfundo Zofunika Kwambiri pa Colchicine kwa Gout
1.
Colchicine ndi alkaloid yomwe imachokera ku mbewu zouma za Colchicum autumnale, yomwe imadziwikiranso kuti autumn crocus kapena safironi yamphesa.
Kugwiritsiridwa ntchito kwa colchicum alkaloid pochizira poyizira kwambiri kunayamba zaka 1810. Colchicum ndi mankhwala oyenerera kuti adziwonetsedwe m'zaka za zana loyamba AD AD Colchicine wakhala akugwiritsidwa ntchito poyendetsa zinthu zina kuposa gout, kuphatikizapo:
- Amyloidosis
- Matenda a Behcet
- Dermatitis herpetiformis
- Chiwopsezo chotchuka cha Mediterranean
- Matenda a Paget
- Pericarditis
- Pseudogout
- Biliary ndi hepatic cirrhosis
2. Colchicine imapezeka m'mayesero olankhula kapena pakamwa.
Colchicine imapezeka pamalowedwe awiri - 0 mg ndi mapiritsi a 0.6 mg. Mankhwalawa amapezekanso mwachangu, koma pali njira yowopsa ya poizoni pogwiritsa ntchito njira ya parenteral (mwachitsanzo, intravenous kapena jekeseni, njira yina osati njira yogaya chakudya).
3. Colchicine ali ndi zotsutsana ndi zotupa, koma ntchito yake kwa mitundu ya ululu kupatulapo gout ndi yoperewera.
Ngakhale kuti colchicine imawoneka kuti ikugwira ntchito kwambiri pofuna kuchiza matenda a nyamakazi, sizothandiza pa mitundu yonse ya ululu. Colchicine sichiwerengedwa ngati mankhwala a analgesic (ie, painkiller). Sizimakhudzanso uric acid clearance.
4. Colchicine amagwira ntchito mosiyana ndi mavuto ena omwe amachititsa ululu kapena mankhwala osokoneza bongo.
Colchicine imamangiriza kwa mapuloteni m'magulu a michere a neutrophils. Neutrophils ndi mtundu wa selo loyera la magazi . Pogwiritsa ntchito neutrophils, maselo sangathe kusamukira kumalo oponderezedwa ku uric acid crystal deposits. Colchicine ali ndi mphamvu yochepetsera yomwe imathandiza kuchepetsa kugwidwa koopsa kwa gout , potero kumachepetsa ululu ndi chisokonezo chogwirizana ndi gout.
5. Colchicine imalimbikitsidwa kuti agwiritse ntchito nthawi zonse pakati pa zoopsya ngati chiwerengero cha prophylactic ndipo zingakhale zothandiza kuthetsa chiwonongeko poyambanso chizindikiro choyamba cha vuto.
Mankhwala omwe amachitidwa kuti athetse vutoli ndi 1 1.2 mg (awiri a 0,5 mg kapena mapiritsi a 0.6 mg). Mlingo uwu ukhoza kutsatiridwa ndi chigawo chimodzi cha piritsi la mphamvu iliyonse ora, kapena maunite awiri maola awiri onse mpaka kupweteka kumasulidwa. Pambuyo pa mlingo woyamba, nthawi zina zimakhala zokwanira kutenga 0,5 kapena 0,6 mg maola awiri kapena atatu. Mankhwalawa ayenera kuyimitsidwa ngati pali m'mimba osasangalatsa kapena kutsekula m'mimba.
6. Colchicine ikhoza kuperekedwa mosalekeza monga chithandizo chamatenda.
Kwa odwala omwe ali ndi masewera osachepera amodzi pa chaka, mlingo wamba ndi 0,5 kapena 0,6 mg pa tsiku, masiku atatu kapena anai pa sabata. Kwa omwe ali ndi zowononga kangapo pa chaka, mlingo wamba ndi 0,5 kapena 0,6 mg tsiku ndi tsiku.
Matenda owopsa angafunike awiri kapena atatu a 0.5 mg kapena mapiritsi a 0,6 mg tsiku lililonse.
7. Zotsatira zoipa zingatheke ndi ntchito ya colchicine ndipo ndizofunika kuti muzindikire zomwe zingatheke.
Matenda a mitsempha ya mafupa , okhala ndi vuto la kuchepa kwa magazi, ndi agranulocytosis, kapena ndi thrombocytopenia angakhalepo kwa odwala omwe athandizidwa nthawi yaitali.
Zina zowonongeka zowonongeka ndizo:
- Peripheral neuritis
- Purpura
- Myopathy
- Kutaya tsitsi
- Reversible azoospermia (kuthetsa kusamvana kwa umuna)
Kuwombera, kutsekula m'mimba, ndi kunyoza ndi zotsatirapo zomwe zingachitike ndi mankhwala a colchicine, makamaka pamene mlingo waukuluwo ukulamulidwa.
8. Amayi oyembekezera ayenera kuyeza kuopsa kwa ntchito ya colchicine.
Colchicine iyenera kugwiritsidwa ntchito panthawi yomwe mayi ali ndi mimba pokhapokha ngati phindu lomwe lingapindule limatsimikizira kuti pangakhale chiopsezo kwa mwanayo. Colchicine akhoza kumanga kusuntha kwa selo, kotero zikhoza kukhala chiopsezo chachikulu kutenga mankhwalawa pamene uli ndi pakati. Chenjezo liyeneranso kugwiritsidwa ntchito pamene colchicine ikuperekedwa kwa mayi yemwe akuyamwitsa.
9. Colchicine sayenera kugwiritsidwa ntchito ndi odwala ena.
Colchicine sayenera kugwiritsidwa ntchito ndi munthu yemwe amadziwika ndi hypersensitivity kwa mankhwala, kapena ndi wodwalayo ali ndi ubongo waukulu, chiwindi, chitsimikizo, kapena matenda a mtima. Komanso, odwala omwe ali ndi matenda a magazi sayenera kugwiritsa ntchito colchicine.
10. Colchicine imafuna mankhwala olembedwa ndi dokotala wanu.
Colchicine ndi mankhwala a mankhwala omwe amapezeka mu mawonekedwe enieni komanso monga mankhwala, dzina la Colcrys (pepala la 0.6 mg). Kuti achepetse zotsatira zake, colchicin ingatengedwe ndi chakudya.
Zotsatira:
Colchicine. RxList. Internet Index Drug Index. Inakambirananso 10/04/2010.
http://www.rxlist.com/colchicine-drug.htm
Colchicine. MedlinePlus. 02/01/2010.
https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682711.html
Kulimbitsa. Sintha 12/2015.
https://www.colcrys.com/
Kelley's Textbook ya Rheumatology. Elsevier. Kusindikiza kwachisanu ndi chinayi. Chaputala 95: Momwe Mungagwiritsire Ntchito Zipatala ndi Chithandizo cha Gout - Colchicine.