Mankhwala atsopano a HCV
FDA imalandira chithandizo cha hepatitis C kuyambira kumayambiriro kwa zaka za 1990 pamene interferon-alfa inapezeka ngati katemera kamodzi ka mlungu kwa HCV. Pa zaka makumi awiri zikubwerazi, interferon kapena mankhwala ochotsedwanso, peginterferon kapena opanda oral ribavirin, inali yoyang'anira chisamaliro cha matenda a hepatitis C. Interferon amagwira ntchito mosalongosoka pa kachilomboko poonjezera chiwopsezo chamatenda achilengedwe cha munthu amene watenga kachilomboka.
Mankhwalawa anali ovuta kulekerera, ankaphatikizapo jekeseni kawirikawiri kwa chaka chimodzi, ndipo anali ndi zotsatira zabwino zokha 6% -54%. Mwachionekere, mankhwala oyenera anali oyenerera.
Mu 2011, a FDA adavomereza mankhwala oyambirira omwe ankachita mwachindunji makina opatsirana kachilombo ka HIV. Awa anali HCV protease inhibitors: boceprevir ndi telaprevir. Iwo anali othandizira kuthetsa kubwereza kwa tizilombo, koma chifukwa cha kutuluka kwa tizilombo toyambitsa matenda kwa mankhwala, amayenera kuperekedwa pamodzi ndi peginterferon ndi ribavirin. Tsono ngakhale kuti mitengo yotsatirayi inakwera kufika 69% -74%, zotsatira za katatu mankhwala osokoneza bongo zinasokonezeka kwa odwala ambiri. Mankhwalawa samagwiritsidwanso ntchito ku United States masiku ano.
Choyamba chachikulu chinayamba mu 2013 ndi chivomerezo cha sofosbuvir ndi simeprevir. Ngakhale kuti poyamba aliyense adavomerezedwa kuti agwiritsidwe ntchito ndi peginterferon kwa genotype 1, kugwiritsa ntchito mankhwala osagwiritsidwa ntchito pamasom'pamodzi popanda kuphatikizira, posakhalitsa kunakhala ntchito yaikulu.
Mavuto opambana anafikira 90% kapena apamwamba; ndipo kupeĊµa interferon kunatanthauza kuti mankhwalawa analoledwa bwino kwa milungu 12 mpaka 24 ya chithandizo chamankhwala. Komabe, othandizirawa anali okwera mtengo ndipo zovuta zochepa kwambiri komanso matenda a hepatitis C adakali ndi peginterferon ( MAVUTO OTHANDIZA ).
Izi zidakalibe vuto la chithandizo cha HCV mpaka mwezi wa October 2014 ndi kuvomerezedwa ndi pepala limodzi lokha la kuphatikiza sofosbuvir ndi ledipasvir (HARVONI). Pulogalamuyi inagwiritsidwa ntchito kwambiri m'magulupakati 1 ndi 4 popanda zofunikira za peginterferon kapena ribavirin. Imakhalabe chithandizo chofunika kwambiri cha hepatitis C ku United States. Komabe pali zizindikiro zina zofunika. Popeza sofosbuvir sayenera kuperekedwa kwa odwala omwe ali ndi vuto lalikulu la impso (kulandila kulenga kosakwana 30 mL / min), mawonekedwe a piritsi imodzi ali ndi chiletso chomwecho. Komanso, mankhwala sayenera kuperekedwa kwa iwo omwe amatenga Amiodarone, mankhwala amtima. Proton pump inhibitors (Prevacid, Neium, ndi zina zotero) zingachepetse mphamvu za mankhwalawa ndipo ziyenera kuyendetsedwa bwino.
Patapita ochepa mu 2014, AbbVie adalengeza kuti FDA ikuvomerezedwa ndi ma ARV omwe amatchedwa Viekira Pak (VIEKIRA PAK). Kuphatikiza kumeneku kuli ndi mankhwala awiri, kamodzi tsiku ndi tsiku, mankhwala opangidwa pamodzi: Ombitasvir ndi Paritaprevir ndi Dasabuvir ya mankhwala tsiku ndi tsiku. Paritaprevir imapangidwanso ndi mankhwala opatsa mphamvu, ritonavir, kuti likhale ndi mphamvu ya Paritaprevir.
Pomalizira, kwa genotype 1a matenda, kuphatikiza uku kumaperekedwa ndi ribavirin kawiri tsiku ndi tsiku. Kuphatikizana kumeneku kumakhala kolimba kwambiri mu matenda a genotype 1 omwe alibe kapena odwala matendawa. Kuphatikizana ndi kotetezeka ndi ogwira mtima kwa odwala omwe ali ndi chifuwa chachikulu, koma sangakhale otetezeka kwa iwo omwe ali ndi umboni wa malipiro ( Chenjezo ) ( Nchiyani chimapha odwala matenda a chiwindi? ). Zovuta zazikulu zothandizidwa ndi mankhwalawa ndizogwirizanitsa mankhwala osokoneza bongo chifukwa cha ritonavir ndi chiwerengero cha mapiritsi omwe amayenera kutengedwa tsiku lililonse.
Pofika kumapeto kwa 2015, mankhwala atsopano ogonjetsedwa ndi FDA ndi Daclatasvir (DACLATASVIR).
Izi ndi mankhwala omwe amachititsa kuti kachilombo ka HIV kakhale kofanana ndi sofosbuvir koma ali ndi mtundu wina wa mankhwala, kotero kupereka mankhwalawa pamodzi kumalola kuti mitundu yonse ya HCV isayankhidwe popanda kugwiritsa ntchito peginterferon kapena ribavirin, koma ikulimbikitsidwa ndi genotype 3 makamaka . Komabe, pali mankhwala ogwiritsira ntchito mankhwala osokoneza bongo ndi Daclatasvir, kotero kuyankhulana ndi dokotala kapena wamasitolo akulimbikitsidwa.
Mankhwala ena awiri atsopano a hepatitis C akuyembekezeredwa kumayambiriro kwa chaka cha 2016. Izi zidzakambidwa ndi lipoti lomwe likubweralo.Ungapezenso zambiri zokhudza chiwindi cha hepatitis C kuchokera ku American Liver Foundation (ALF)