Matenda a Polycystic ovarian, kapena PCOS , ndi mkhalidwe umene mazira a mkazi ndi adrenal glands amapanga kwambiri androgens kuposa yachibadwa, zomwe zimapangitsa kuwonjezera tsitsi la tsitsi, ziphuphu ndi zosasintha nthawi.
Ngakhale kuti ofufuza sakudziwa chifukwa chenicheni cha PCOS, zimadziwika kuti kusamvana kwa dongosolo la endocrine kumayambitsa kusintha kwakukulu komwe kumayenderana nawo.
Komabe, sikudziwika chomwe chimayambitsa kusintha.
Pano pali kuyang'ana pa mfundo zazikulu zomwe amakhulupirira kuti ziri kuseri kwa PCOS:
The Hypothalamic-Pituitary-Ovarian Axis
Mahomoni ndi mapuloteni opangidwa ndi thupi mkati mwa thupi lomwe limapangitsa kusintha mkati mwa selo kapena chiwalo. Pulojekiti ya Hypothalamic-Pituitary-Ovarian (HPO) ndiyo dongosolo la mahomoni m'thupi.
The hypothalamus ndi gland mkati mwa ubongo yomwe, ikakonzedwa, imatulutsa mahomoni, otchedwa Gonadotropin-Releasing Hormone kapena GnRH. GnRH amapita ku chidziwitso cha pituitary, kachilombo kakang'ono mu ubongo. Chithokomirochi chimapanga mahomoni osiyanasiyana omwe amayang'anira ndi kusunga ntchito zambiri za thupi.
Ofunika kwa PCOS, pituitary imapanga FSH , kapena Hormone Kupangitsa Hormone, ndi LH , kapena Lutenizing Hormone. LH amapita ku ovary kumene imayambitsa kupanga androgens .
Zakhala zikugodometsedwa kuti maulendo apamwamba a LH ndi androgens, omwe ndi testosterone, amachititsa PCOS.
Komabe, izi sizikutanthawuza chifukwa chake amayi ambiri omwe ali ndi PCOS alibe ammwambamwamba a LH.
Kulumikizana kwa Insulini-Androgen
Insulini yakhala ikuganiza kuti ili ndi gawo mukulinganiza kwa PCOS. Kuwonjezera pa kuyang'anira makilogalamu a shuga, insulini imachititsa kuti chiwindi chichepetse kupanga kwa kamolekisi yofunika yotchedwa glomin-binding hormone, kapena SHBG.
Testosterone imachitika m'magazi ndi SHBG pamene molecule ilipo. Ngati kuchepa kwa SHBG kulipo, testosterone yaulere (testosterone yomwe siimatengedwa ndi SHBG) ili m'magazi. Amakhulupirira kuti ma insulini ambiri amatha kuchulukitsa kuchuluka kwa androgens omwe amapanga ovary.
Izi sizikutanthauzira kwathunthu PCOS, monga amayi ambiri omwe ali ndi PCOS alibe insulin kukana , kusintha kwa momwe maselo a thupi amachitira ndi insulini, ndi vuto lomwe limawoneka pa PCOS.
Genetics
Chinthu chimodzi chofunikira ndi PCOS ndi chakuti mumathamanga m'mabanja. Amayi omwe ali ndi PCOS amakhala ndi mlongo, amayi, msuweni kapena azakhali omwe ali ndi vutoli. Ngakhale madokotala sakudziwa chifukwa chake chenichenicho, izo zikugwirizanitsa momveka bwino ndi chibadwidwe.
Akatswiri ofufuza tsiku lililonse amazindikira kuti pali zolakwika zomwe zingakhale zolakwika. Izi zimakhala zovuta chifukwa cha kusowa kwa chidziwitso chimodzi chokha komanso zomwe zimachitika kunja (monga kunenepa kwambiri, zakudya ndi machitidwe ochita masewera olimbitsa thupi) zingathe kusewera pa chitukuko cha matendawa.
Zotsatira:
Harris, Colette ndi Carey, Adam. PCOS: Mutu wa Mkazi Wothana ndi Polycystic Ovary Syndrome .Thorson; London. 2000.
Thatcher, Samuel. PCOS: Mliri Wobisika . Zolemba; Indianopolis. 2000.
Prapas N, Karkanaki A, Prapas I, Kalogiannidis I, Katsikis I, Panidis D. Genetics wa Polycystic Ovary Syndrome. Hippokratia . 2009; 13 (4): 216-223.