Kuchiza chithandizo kungayambitse kubwezera kwakukulu kwa MS
Tysabri (natalizumab) ndi mankhwala osinthira matenda omwe amagwiritsidwa ntchito pochizira kubwerera kwa anthu omwe ali ndi multiple sclerosis (MS) . Zimalepheretsa kuti maselo a chitetezo cha m'magazi athe kupewera mitsempha ya ubongo yomwe imalekanitsa ubongo ndi msana kuchokera ku thupi lonse. Ndi maselo amenewa omwe angawononge mitsempha pamene amawavulaza mwadzidzidzi zovala zawo zoteteza (zomwe zimadziwika kuti myelin sheath ).
Tysabri imavomerezedwa ndi US Food and Drug Administration (FDA) kuti agwiritsidwe ntchito mu MS monotherapy (kuti asagwirizane ndi mankhwala ena) ndipo imayendetsedwa intravenously masiku onse 28.
Mavuto Ogwirizana ndi Kugwiritsa Ntchito Tysabri
Ngakhale kuti Tysabri yasonyezedwa kuti kuchepetsa kubwerera kwa anthu omwe ali ndi MS ndi 68 peresenti yochititsa chidwi, siziri zopanda pake. Mu 2005, a FDA adatumiza chenjezo lakuda labasi akulangiza odwala ndi madokotala kuti Tysabri anali pafupi ndi awiri mwa anthu 1,000 aliwonse omwe ali ndi vutoli lomwe limatha kupha khansa yotchedwa multifocal leukoencephalopathy (PML) .
Chodabwitsa china chodziwika ndi chodabwitsa chomwe chimadziwika kuti kubwezeretsedwa kumene kusokonekera kapena kusokonezeka kwa mankhwalawa kunayambitsa kubwerera kwa zizindikiro za MS , ndipo nthawi zina zimakhala zovuta kuposa pamene mankhwala anayamba.
Kumvetsetsa Zotsatira Zowonongeka
Zomwe zinayambitsa matenda a Tysabri zinayamba kudziwika mu 2007 pamene akatswiri ofufuza a ku Dutch anafufuza mayeso a MRI a anthu omwe adatenga Tysabri koma anayenera kusiya pamene mankhwalawa adachotsedwa pamsika chifukwa cha nkhawa za PML.
Pakati pa miyezi isanu ndi iwiri yapakati ya chithandizo, asayansi apeza kuti chiwerengero cha zilonda zapakati pa mitsempha yazitsulo chawonjezeka kuchokera pa pafupifupi 3.43 kumayambiriro kwa chithandizo mpaka 10.32 mutatha mankhwala.
Chodabwitsa kwambiri, zotsatirazi sizinawoneke kuti zikuipiraipira mwa anthu amene akhala akuchiritsira kwautali.
Ndipotu, zinali zosiyana kwambiri. Malinga ndi kafukufukuwo, omwe adalandira mankhwala ena a ma ARV amakhala ndi zilonda zisanu kuposa omwe akhala akuchiritsidwa kwa nthawi yonse yophunzira (pafupifupi 36 infusions).
Kafukufuku wofananamo mu 2014 adathandizira zotsutsa izi ndipo adatsimikizira kuti kusokonezeka kwa mankhwalawa kunalumikizidwa ndi kuwonjezereka kawiri kawiri pangozi yobwereranso. Zambiri zokhudzana ndizimenezo zinalidi kuti gawo limodzi mwa magawo atatu a anthuwa anali atabwerera kachiwiri atasiya Tysabri kuposa momwe chithandizo chisanayambe.
Zimene Izi Zikutiuza
Asayansi samadziwa kwathunthu chifukwa chake izi zowonjezera zimachitika. Zomwezo zakhala zikugwiritsidwa ntchito m'ma mankhwala ena a MS, kuphatikizapo Gilenya (fingolimod) , ndipo palibe nzeru zochepa zokhudzana ndi zomwe zingachitike kuti zisachitike.
Chimene tikudziwa ndi ichi: Anthu omwe ali pachiopsezo chachikulu ndi omwe amatenga miyezi ingapo ya Tysabri ndikusiya. Ngati mankhwala ali ndi Tysabri akulimbikitsidwa, inu monga wodwalayo muyenera kuchita kuchipatala ndi kumamatira. Simungathe kutenga maholide osokoneza bongo kapena kusankha kuima ngati mutakhala bwino.
Chithandizo chakumapeto chiyenera kutsogoleredwa ndi katswiri wodziwa bwino yemwe angathe kudziwa ngati Tysabri sakufunikanso.
> Zotsatira:
> Fox, R .; Cree, et al. Ntchito ya matenda a MS ku RESTORE: Kuphunzira kusokonezeka kwa masabata 24 a natalizumab. " Neurology 2014; 82 (17): 1491-8.
> Sorensen, P .; Koch-Henrikson, H ;; Petersen, T. et al. "Kuchulukanso kapena kubwezeretsanso matenda a kachipatala atasiya mankhwala otchedwa natalizumab mankhwala odwala kwambiri MS." J Neurol . 2014; 261 (6): 1170-7.
> Vellinga, M .; Castelijns, J ;; Barkhof, F. et al. "Kuwonjezeka kwa chiwerengero cha post2drawal kuwonjezeka kwa ntchito ya T2 m'magulu a MS a natalizumab." Neurology. 2008; 70 (13): 1150-1.