Magulu angapo - kuphatikizapo mabakiteriya, mavairasi (monga Epstein-Barr HIV), ndi tizilombo toyambitsa matenda - amayanjanitsidwa ndi lymphoma. Ndipotu, pafupifupi 18 peresenti ya matenda a khansa padziko lonse angagwirizane ndi majeremusi, malinga ndi kafukufuku wina. Komabe, kutengera kachilombo kokhako sikukwanira kuchititsa matenda ambiri. Palinso zinthu zina zofunika zomwe zimagwiritsidwa ntchito, kuphatikizapo majini ndi kusiyana kwa thupi kumatenda a thupi kumatendawa.
EBV ndi Lymphoma
Vuto la Epstein-Barr (EBV), kachilombo kamene kamayambitsa matenda opatsirana a mononucleosis , limakhudza anthu ambiri padziko lonse lapansi. Ndipotu, anthu opitirira 90 peresenti ya anthu onse amatha kutenga kachilombo ka EBV, ndipo kachilombo ka HIV kamapitirirabe, ngakhale kukhalapo kwake kungakhale kochepa kwa anthu ambiri. Matenda ambiri a EBV mwa ana ali ndi zizindikiro zosiyana kapena zimayambitsa zizindikiro zosadziwika, pamene matenda omwe amabwera koyambirira paunyamata angayambitse matenda opatsirana a mononucleosis mwa 50 peresenti ya odwala.
Chomwe chimapangitsa EBV kukhala yosiyana ndi malo openya a lymphoma ndi chakuti ili ndi mitundu yapadera ya majini yomwe imayambitsa kukula kwa maselo omwe amachititsa. EBV imakhudza makamaka B-maselo (mtundu wa selo loyera la magazi). Ngakhale kuti nthawi zambiri kachilomboka kamayambitsa mavuto ena, nthawi zina majini opangira kukula m'maselo a B akhoza kugwiritsidwa ntchito ndi khansa mwa anthu ena. Choncho, EBV imaonedwa kuti ndiyo ngozi ya mtundu wina wa lymphoma.
Kutulutsa Lymphoma ndi E-Associated Lymphoma
EBV imagwirizana kwambiri ndi kukula kwa lymphoma pambuyo pathupi . Pambuyo pa mtundu uliwonse wa kulumikizidwa kwa thupi , iwo omwe alandira kubzala ayenera kupatsidwa mankhwala omwe amathandiza kuti chitetezo cha mthupi chitetezeke ku zakunja. Izi zimapangitsa chiwalo chopachika kuti chiteteze chitetezo cha mthupi mwa wolandira, koma mankhwalawa, mwatsoka, akhoza kufooketsa chitetezo cha mthupi ndi kupangitsa thupi kukhala ndi kachilombo ka HIV, kuphatikizapo EBV.
Panthawi ya Edzi, palinso kutaya chitetezo cha mthupi pamatenda opatsirana m'thupi. Nthawi zina, mavairasi monga EBV angayambitse kukula kwachilombo cha ma B-maselo ndikuthandizira kukhala maselo amphamvu.
Burkitt's Lymphoma ndi Malaria
Burkitt lymphoma, kapena BL, ndiyo yowopsa kwambiri yopanda ana a Hodgkin lymphoma kwa ana ndi achinyamata omwe ali padziko lonse lapansi. M'madera ambiri a Africa, EBV imagwirizana kwambiri ndi Burkitt's lymphoma . Makamaka, kukhala ndi matenda a EBV oyambirira akugwirizana ndi chitukuko cha BL. EBV imayambitsa kusintha kwa ma geneeni komwe kumathandiza kuti maselo a B akhale khansa. Matenda a malungo amathandizanso kuti EBV ipangitse ma lymphomas.
Matendawa amatchedwa Dr. Denis Burkitt, mishonare wa ku Ireland, ndi dokotala wa opaleshoni amene ankagwira ntchito ku Africa. Burkitt ndi anzake adapeza BL mu 1957, pamene milandu inalipo m'madera omwe malungo analipo - omwe amatchedwa lamba la lymphoma. Komabe, malungo ndi majeremusi omwe amachititsa maselo ofiira a magazi, osati maselo oyera a mitsempha ya lymphoma, kotero kuti njira yeniyeniyo inali yosadziwika kwa zaka 50.
M'chilimwe cha 2015, komabe, kuwala kunakhetsedwa pa phunziroli, ngakhale mu maphunziro a zinyama. Kugwira ntchito ndi mbewa, ofufuza pa yunivesite ya Rockefeller motsogoleredwa ndi Michel Nussenzweig adapeza kuti mankhwala omwe amathandiza kupanga ma antibodies kuti amenyane ndi malungo amachititsanso kuti DNA iwonongeke yomwe ingabweretse Burkitt's lymphoma.
Kafukufukuyu anafalitsidwa mu August 2015 m'nkhani yakuti "Cell."
Lymphoma ya Hodgkin
Hodgkin's lymphoma , kapena HL, ndi mtundu wina wa lymphoma womwe umagwirizanitsidwa ndi EBV. M'mayiko akumadzulo, pafupifupi 40 peresenti ya anthu omwe ali ndi HL ali ndi kachilombo ka EBV. Mliri wa kachilomboka ukhoza kukhala wapamwamba kwambiri m'madera ena ambiri padziko lapansi. Njira yeniyeni yomwe EBV ingayambitsire Hodgkin's lymphoma sikumveka bwino, koma zikuwonekera bwino kuti EBV ili ndi udindo wofunikira kwambiri pakukula kwa lymphoma. Ngakhale zikhoza kugwirizanitsidwa ndi mitundu yosiyana ya matenda a Hodgkin, omwe amavuta kwambiri ndiwo mawonekedwe osakanikirana, a Hodgkin's lymphoma.
HL m'magulu okalamba ndi ana, makamaka anyamata osapitirira zaka 10, awonetsedwa kuti akhoza kukhala EBV-okhudzana ndi HL achinyamata.
EBV-positive Yopambana B-cell Lymphoma ya Akuluakulu
Ngakhale kuti kufalikira kwa B-cell lymphoma (DLBCL) yaikulu kwadzidzidzi kwatha, DLBCL ya EBV-okalambayo inayamba kufotokozedwa mu 2003, ndipo inalembedwa pokhapokha mu dongosolo la World Health Organisation la 2008 - lomwe limafotokoza kuti "EBV -kukula kwakukulu kwachilendo cha B-cell chomwe chimapezeka kwa odwala> zaka 50 ndipo palibe amene amadziwika kuti ali ndi immunodeficiency kapena mbiri ya lymphoma. "Matendawa amapezeka kwambiri ku Asia koma amapezeka ku North America ndi Europe pafupipafupi .
> Zotsatira:
> Brady G, MacArthur GJ, Farrell PJ. Epstein-Barr HIV ndi Burkitt lymphoma. Journal of Clinical Pathology. 2007; 60 (12): 1397-1402.
> Kapatai G, Murray P. Zopereka za kachilombo ka Epstein-Barr ku ma pathogenesis a Hodgkin lymphoma. Journal of Clinical Pathology. 2007; 60 (12): 1342-1349.
> Ok CY, Papathomas TG, Medeiros LJ, Young KH. EBV-positive imafalitsa kwambiri B-cell lymphoma ya okalamba. Magazi. 2013; 122 (3): 328-340.
> Yunivesite ya Rockefeller. Science News. Kafukufuku watsopano amathandiza kufotokoza chifukwa chake khansa ya magazi yoopsa imakhudza ana omwe ali ndi malungo.