Otrexup Ndi Dokotala Wodzipangira Wodwala Wodzipaka Mavitamini
Otrexup ( methotrexate ) ndi auto -jectorous-dose-autosejector yomwe imakhala ndi mankhwala ovomerezeka a mankhwala. Otrexup poyamba inavomerezedwa ndi US FDA pa Oktoba 11, 2013. Otrexup, yopangidwa ndi Anatares Pharma, Inc. ndi njira yotsutsana ndi methotrexate ya m'kamwa, mankhwala otchedwa vial-and-syringe omwe amajambulidwa ndi methotrexate, kapena amodzi a doi autoinjector, Rasuvo .
Zizindikiro za Otrexup
Otrexup, mtundu wa analog inhibitor, unali wa FDA-wovomerezeka kuti azitsatira anthu omwe ali ndi nyamakazi yambiri , yogwira mtima ndi nyamakazi yambiri yomwe sankalandira mankhwala oyamba. Otrexup nayenso inavomerezedwa kuti ikhale ndi mphamvu zowononga zizindikiro zowopsya, zomwe zimalepheretsa psoriasis kukhala anthu akuluakulu omwe sanalandire mankhwala ena. Otrexup sichivomerezedwa kuti chithandizo cha matenda opatsirana.
Ulamuliro wa Otrexup
Kuyambira mlingo wa methotrexate ndi 7.5 mg kamodzi pamlungu kwa anthu omwe ali ndi nyamakazi, 10 mg / m2 kamodzi pamlungu kwa odwala omwe ali ndi nyamakazi yambirimbiri, komanso 10 mpaka 25 mg kamodzi pamlungu pa psoriasis. Otrexup imayendetsedwa monga jekeseni kamodzi pamlungu, subcutaneous. Zitha kuikidwa mu ntchafu kapena mimba pamayendedwe.
Otrexup imapezeka mlingo wa pakati pa 10 mpaka 25 mg muwonjezerapo 5 mg.
Kukonzekera kwina kwa methotrexate, kupatulapo Otrexup, kuyenera kugwiritsidwa ntchito kwa odwala omwe amafuna kuyankhula, pakamwa, m'mimba, m'mimba, kapena m'thupi, mlingo wosachepera 10 mg pa sabata, mlingo waukulu kuposa 25 mg pa sabata, miyezi yapamwamba , kapena kusintha kwa mlingo kosachepera 5 mg.
Contraindications
Otrexup sayenera kugwiritsidwa ntchito ndi amayi apakati, amayi oyamwitsa, kapena omwe ali ndi matenda a chiwindi kapena uchidakwa. Komanso, Otrexup iyenera kupeĊµedwa ndi anthu omwe ali ndi matenda a immunodeficiency syndromes, matenda omwe alipo kale omwe amapezeka m'magazi, kapena odziwika kuti hypersensitivity kwa methotrexate.
Zochitika Zowonongeka Zowonongeka
Otrexup imagwirizanitsa ndi zotsatira zowonongeka, kuphatikizapo: kunyowa, kupweteka kwa m'mimba, kupweteka kwa pakamwa, zilonda zamilomo, zilonda zam'mimba, nasopharyngitis, kutsekula m'mimba, chiwindi, kugwira ntchito, kusanza, mutu, bronchitis, kuchuluka kwa magazi oyera maselo, kusowa kwa mitundu yonse ya maselo a magazi, chizungulire, photosensitivity, ndi alopecia.
Ngati mukukumana ndi zovuta kapena zoipa, mungathe kuwuza FDA ku http://www.fda.gov/medwatch/ kapena kuitana 1-800-FDA-1088. Mutha kulankhulana ndi wopanga Otrexup pa http://www.otrexup.com kapena pakuitana 1-855-Otrexup (1-855-687-3987).
Kuyanjana kwa Mankhwala
Kutenga aspirin , NSAIDs , kapena corticosteroids ndi Otrexup zingapitirize kukula kwa maselo a serum methotrexate chifukwa cha kuwonjezeka kwa poizoni. Kutenga proton pump inhibitors pogwiritsira ntchito Otrexup kungakhalenso kuwonjezeka ndi kutalikitsa maseĊµera a serum methotrexate, kuwonjezera chiopsezo cha poizoni.
Onetsetsani kuti dokotala ali ndi mndandanda wamakono wa mankhwala onse ndi zowonjezereka zomwe mumatenga. Ndibwino kugwiritsira ntchito mankhwala amodzi, ngati n'kotheka, mankhwala anu onse. Ndi kosavuta kufufuza momwe mungagwiritsire ntchito mankhwala osokoneza bongo ngati mankhwala anu onse ali mu kompyuta ya mankhwala omwe mumasankha.
Chenjezo ndi Kusamala
Pali chenjezo lakuda lakuda lomwe limagwirizanitsidwa ndi Otrexup lomwe likunena kuti zotsatira zoopsa za poizoni ndi imfa zakhala zikugwiritsidwa ntchito ndi methotrexate. Odwala omwe akugwiritsa ntchito mankhwalawa ayenera kuyang'anitsitsa mafupa, chiwindi, mapapo, khungu, ndi impso za impso. Methotrexate inanenedwa kuti imayambitsa imfa ya fetus kapena zolakwika zomwe zimachitika chifukwa chakutenga.
Matenda osokonekera a mafupa osakanikirana, kupatsirana kwa magazi, ndi kuchepa kwa poizoni akhala akudziwika kwa odwala omwe amatenga NSAID pamene akugwiritsa ntchito methotrexate. Chiwindi cha poizoni, fibrosis, ndi cirrhosis chikhoza kuchitika pambuyo pa ntchito yaitali ya methotrexate. Mphuno ya pneumonitis ikhoza kuchitika nthawi iliyonse komanso ngakhale kuchepa kwa methotrexate. Kutsekula m'mimba, ulcerative stomatitis, kupweteka kwa m'mimba, ndi m'mimba zimatha kuchitika. Zovuta, zomwe zingathe kupha, khungu limatha kuchitika. Momwemo matenda opatsirana omwe angathenso kuwopsa angayambe.
Non-Hodgkins lymphoma ndi zotupa zina zafotokozedwa kwa odwala omwe ali ndi mlingo wotsika wa methotrexate. Tiyenera kukumbukira kuti pamene mankhwala oopsa a lymphoma anayamba kupangidwa ndi mankhwala a methotrexate, kuletsa methotrexate kunali kokwanira kuti vuto la lymphoma likhale lopweteka.
Methotrexate imanenanso kuti yachititsa kuti odwala ena asatengeke, kuchepa kwa umuna komanso kusamba. Izi zingakhale zovuta pamene methotrexate imagwiritsidwa ntchito komanso kwa nthawi yayimitsa.
Mawu Ochokera
Anthu ogwiritsa ntchito Otrexup ayenera kukhala ndi mayesero a magazi nthawi zonse kuphatikizapo kuchuluka kwa magazi, mazira a chiwindi, ndi mayeso a ntchito za impso. Ngati mukuganiza kuti mapulaneti amadziwika, ziyeso zapadera zogwiritsira ntchito chifuwa ndi ziwalo zingakhale zofunikira.
Anthu ogwiritsa ntchito Otrexup ayenera kudziwa kuti zingakhale zovuta, kuti athe kuzindikira ndi kulongosola nkhani mwamsanga akangochitika. Zoonadi, mndandanda wa zochitika zoopsa ndi zoopsa, koma kumbukirani, anthu ambiri amagwiritsa ntchito methotrexate popanda kukumana ndi mavuto aliwonse. Kuzindikira ndi kuwunika n'kofunikira.
Zotsatira:
Otrexup. Kufotokozera Uthenga Wathunthu . Revised 3/2016.
Otrexup Approval History. Drugs.com.