Kamodzi-Sabata Pambuyo pa Autoinjector
Rasuvo (methotrexate), auto -jector ya dose imodzi yomwe imakhala ndi mankhwala ovomerezeka a mankhwala, inavomerezedwa ndi US Food and Drug Administration (FDA) pa July 11, 2014. Rasuvo, yopangidwa ndi Medac, Pharma, Inc. ndi yosavuta- gwiritsani ntchito njira yotsutsana ndi methotrexate kapena mawonekedwe a vial-syringe.
Zizindikiro za Rasuvo
Rasuvo imavomerezedwa kuti ayang'anire odwala omwe ali ndi matenda amphamvu kwambiri a nyamakazi komanso a nyamakazi omwe amavutika kwambiri ndi mankhwala a mzere woyamba kapena osakondana.
Rasuvo imasonyezedwanso pofuna kuchepetsa zizindikiro zowopsya, recalcitrant, kulepheretsa psoriasis kwa anthu akuluakulu omwe alephera kupeza yankho lokhutiritsa ndi njira zina zothandizira. ( Zindikirani: Rasuvo sayenera kugwiritsidwa ntchito pochiza matenda opatsirana.)
Administration of Rasuvo
Rasuvo imayendetsedwa kamodzi pamlungu ngati jekeseni ya subcutaneous yekha. Rasuvo imapezeka mu mphamvu 10 za mlingo kuchokera 7.5 mg mpaka 30 mg (2.5 mg increments). The autoinjector imayambitsa mwala ndipo imayikidwa mu mimba kapena ntchafu. Mankhwala ena a methotrexate ayenera kugwiritsidwa ntchito ngati mlingo pansi pa 7.5 mg kapena pamwamba pa 30 mg ndiyotchulidwa-kapena ngati kusintha kosakwana 2.5 mg ndikofunikira.
Mlingo woyambirira wa methotrexate wa nyamakazi ya nyamakazi ndi 7.5 mg kamodzi pamlungu kuti adziwe jekeseni wamkati kapena wothandizira. Kwa psoriasis, chizoloŵezi choyamba cha mlingo ndi 10-25 mg kamodzi pamlungu kupyolera pamlomo, pakamwa, pamagulu, kapena m'thupi.
Kwa nthenda yamatenda ya achinyamata yomwe imayambitsa matenda a nyamakazi, chiwerengero choyamba chimakhala 10mg / m2 kamodzi pamlungu (m2 ndi mamita awiri a thupi lanu).
Ndani Sagwiritse Ntchito Rasuvo?
Odwala nyamakazi odwala nyamakazi omwe ali ndi pakati sayenera kugwiritsa ntchito Rasuvo. Ayeneranso kupeŵedwa ndi amayi oyamwitsa, komanso odwala omwe akudwala: chiwerewere kapena chiwindi, matenda a immunodeficiency syndromes, kapena preexisting blood dyscrasias.
Odwala omwe ali ndi hypersensitivity odziwika kuti methotrexate ayeneranso kupewa Rasuvo.
Zochitika Zowonongeka Zowonongeka
Pali njira zambiri zomwe zimayambitsa mavuto omwe amapezeka ndi Rasuvo kuphatikizapo, kunyowa, kupweteka m'mimba, kupweteka m'mimba, zilonda za m'mimba kapena pakamwa, nasopharyngitis, kutsekula m'mimba, kuyesa matenda a chiwindi, kusanza, mutu, bronchitis, thrombocytopenia (platelets low), alopecia, leukopenia kuwerengera), pancytopenia (chiwerengero chochepa cha maselo onse a magazi), chizungulire, ndi kuzindikira kwa ultraviolet kuwala. Ngati muli ndi vuto linalake, mukhoza kulongosola kwa wogulitsa mankhwala pa 1-855-336-3322, kwa FDA pa 1-800-FDA-1088, kapena Medwatch pa http://www.fda.gov/medwatch .
Kuyanjana kwa Mankhwala
Dokotala wanu ayenera kukhala ndi mndandanda wa mankhwala onse ndi zowonjezereka zomwe mukuzitenga panopa. Dziwani kuti mwa kumwa aspirin, mankhwala a NSAID , kapena mankhwala a corticosteroid pamodzi ndi Rasuvo, maseŵera a seramu methotrexate akhoza kukhala aatali (mwachitsanzo, akhoza kukhala m'magazi anu nthawi yaitali) ndipo akhoza kuonjezera chiopsezo cha poizoni.
Kutenga proton pump inhibitors (mwachitsanzo, Nexium kapena omeprazole) ndi Rasuvo kungathenso kuchepetsa ma seramu methotrexate ndikuwonjezera chiopsezo cha poizoni.
Chenjezo ndi Kusamala
Rasuvo imaphatikizapo chenjezo lotchedwa Boxed Warning (mtundu waukulu wa chenjezo).
Mfundo zazikuluzikulu zomwe zafotokozedwa pazochenjezedwa ndi:
- Rasuvo iyenera kugwiritsidwa ntchito ndi madokotala ndi chidziwitso komanso chidziwitso cha mankhwala a antimetabolite. Rasuvo ndi mtundu wa analog wachabecha.
- Chifukwa cha zomwe zimachitika poizoni, mwina amafa, Rasuvo ayenera kulamulidwa okhawo omwe ali ndi nyamakazi, psoriasis, kapena nyamakazi ya mwana wamwamuna yemwe sanamvere mankhwala ena.
- Methotrexate yabwera chifukwa cha imfa ya fetus kapena congenital.
- Kuchotsa methotrexate kumachepetsedwa kwa anthu omwe ali ndi vuto la impso, opites, kapena kupwetekedwa mtima.
- Matenda a mafupa a mitsempha, kuchepa kwa magazi m'thupi, ndi m'mimba amatha kuchitika mosayembekezereka ndipo akhoza kupha ngati methotrexate imatengedwa ndi NSAIDs.
- Kugwiritsiridwa ntchito kwa methotrexate kungapangitse hepatotoxicity, fibrosis, ndi cirrhosis. Mayesero a chiwindi a chiwindi amatha kusonyeza.
- Matenda a m'mapapo omwe amachititsa kuti mitsempha ya m'mimba ikhale yotentha (mwachitsanzo, yovuta komanso yoperewera ya pneumonitis) ikhoza kuchitika, ngakhale pamadzi ochepa.
- Kutsekula m'mimba ndi ulcerative stomatitis kumafuna kuti mankhwala ndi methotrexate amalekeretse kuteteza m'mimba kutsegula m'mimba kapena kupweteka kwa m'mimba.
- Malignant lymphoma ikhoza kukulirakulira ngakhale ndi methotrexate ya mlingo wochepa. Mankhwalawa ayenera kuthetsedwa kuti awone ngati lymphoma imachepetsa.
- Methotrexate ingayambitse "tumor lysis syndrome" kwa odwala omwe akukula mofulumira.
- Kuwopsa, nthawi zina kumapha, khungu limatha kukhala ndi methotrexate ntchito.
- Matenda opatsirana owopsa angayambe ndi methotrexate ntchito.
- Ngati methotrexate ikuperekedwa limodzi ndi radiotherapy, pangakhale ngozi yowonjezera ya minofu yofewa ya necrosis ndi osteonecrosis .
Mfundo Yofunika Kwambiri
Rasuvo ndi maonekedwe abwino a methotrexate. Rasuvo amanyamula zotsatira zake zonse zomwe zimakhala zovuta komanso zochenjeza zomwe zimagwirizanitsidwa ndi njira zina za methotrexate.
Zotsatira
Rasuvo. Kufotokozera Uthenga Wathunthu . Revised 7/2014.
Mbiri Yotsimikizika ya Rasuvo. drug.com.